Fetal vascular adaptation before and after treatment of severe maternal anemia in pregnancy
Abstract Objectives To use color Doppler ultrasonography indices to study the effects on fetal circulation of treating severe maternal anemia. Methods A prospective cohort study enrolled patients who were at 30–34 weeks of pregnancy and had hemoglobin levels below 70 g/L between November 1, 2011 and...
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| Veröffentlicht in: | International journal of gynecology and obstetrics 2016-06, Vol.133 (3), p.284-286 |
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| creator | Ali, Eram Kumar, Manisha Naqvi, Sayyed E.H Trivedi, Shubha S Singh, Anuradha |
| description | Abstract Objectives To use color Doppler ultrasonography indices to study the effects on fetal circulation of treating severe maternal anemia. Methods A prospective cohort study enrolled patients who were at 30–34 weeks of pregnancy and had hemoglobin levels below 70 g/L between November 1, 2011 and March 31, 2013 at a hospital in New Delhi, India. A control group consisting of patients with the same duration of pregnancy and with hemoglobin levels above 110 g/L was included. Umbilical artery and middle cerebral artery velocimetry were performed using color Doppler ultrasonography at admission and after 4 weeks and 6 weeks of treatment. Results The maternal anemia cohort demonstrated a significantly lower middle cerebral artery resistance index and middle cerebral/umbilical artery resistance ratio ( P < 0.001) at admission. Following 4 weeks of treatment for maternal anemia, significant increases in these parameters were observed ( P < 0.001). Conclusion Fetuses of individuals with severe maternal anemia demonstrated altered cerebral and umbilical artery flows. Normal flows were restored following treatment of maternal anemia. |
| doi_str_mv | 10.1016/j.ijgo.2015.11.011 |
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Methods A prospective cohort study enrolled patients who were at 30–34 weeks of pregnancy and had hemoglobin levels below 70 g/L between November 1, 2011 and March 31, 2013 at a hospital in New Delhi, India. A control group consisting of patients with the same duration of pregnancy and with hemoglobin levels above 110 g/L was included. Umbilical artery and middle cerebral artery velocimetry were performed using color Doppler ultrasonography at admission and after 4 weeks and 6 weeks of treatment. Results The maternal anemia cohort demonstrated a significantly lower middle cerebral artery resistance index and middle cerebral/umbilical artery resistance ratio ( P < 0.001) at admission. Following 4 weeks of treatment for maternal anemia, significant increases in these parameters were observed ( P < 0.001). Conclusion Fetuses of individuals with severe maternal anemia demonstrated altered cerebral and umbilical artery flows. Normal flows were restored following treatment of maternal anemia.</description><identifier>ISSN: 0020-7292</identifier><identifier>EISSN: 1879-3479</identifier><identifier>DOI: 10.1016/j.ijgo.2015.11.011</identifier><identifier>PMID: 26961588</identifier><language>eng</language><publisher>United States: Elsevier Ireland Ltd</publisher><subject>Anemia - epidemiology ; Anemia - therapy ; Blood Flow Velocity ; Case-Control Studies ; Cerebral/umbilical resistance ratio ; Doppler velocimetry ; Female ; Fetus - blood supply ; Fetus - diagnostic imaging ; Gestational Age ; Hemoglobins - analysis ; Humans ; India ; Maternal anemia ; Middle cerebral artery ; Middle Cerebral Artery - diagnostic imaging ; Obstetrics and Gynecology ; Parity ; Peak systolic velocity ; Pregnancy ; Pregnancy Complications, Hematologic - epidemiology ; Pregnancy Complications, Hematologic - therapy ; Prospective Studies ; Pulsatility index ; Resistance index ; Severity of Illness Index ; Systolic/diastolic ratio ; Ultrasonography, Doppler, Color ; Umbilical Arteries - diagnostic imaging ; Umbilical artery</subject><ispartof>International journal of gynecology and obstetrics, 2016-06, Vol.133 (3), p.284-286</ispartof><rights>International Federation of Gynecology and Obstetrics</rights><rights>2016 International Federation of Gynecology and Obstetrics</rights><rights>Copyright © 2016 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4594-b8a00bd585e5fdbaeea432bea3017b133b4e8351f01c0a71aaa727defc7298ca3</citedby><cites>FETCH-LOGICAL-c4594-b8a00bd585e5fdbaeea432bea3017b133b4e8351f01c0a71aaa727defc7298ca3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2Fj.ijgo.2015.11.011$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1016%2Fj.ijgo.2015.11.011$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26961588$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ali, Eram</creatorcontrib><creatorcontrib>Kumar, Manisha</creatorcontrib><creatorcontrib>Naqvi, Sayyed E.H</creatorcontrib><creatorcontrib>Trivedi, Shubha S</creatorcontrib><creatorcontrib>Singh, Anuradha</creatorcontrib><title>Fetal vascular adaptation before and after treatment of severe maternal anemia in pregnancy</title><title>International journal of gynecology and obstetrics</title><addtitle>Int J Gynaecol Obstet</addtitle><description>Abstract Objectives To use color Doppler ultrasonography indices to study the effects on fetal circulation of treating severe maternal anemia. Methods A prospective cohort study enrolled patients who were at 30–34 weeks of pregnancy and had hemoglobin levels below 70 g/L between November 1, 2011 and March 31, 2013 at a hospital in New Delhi, India. A control group consisting of patients with the same duration of pregnancy and with hemoglobin levels above 110 g/L was included. Umbilical artery and middle cerebral artery velocimetry were performed using color Doppler ultrasonography at admission and after 4 weeks and 6 weeks of treatment. Results The maternal anemia cohort demonstrated a significantly lower middle cerebral artery resistance index and middle cerebral/umbilical artery resistance ratio ( P < 0.001) at admission. Following 4 weeks of treatment for maternal anemia, significant increases in these parameters were observed ( P < 0.001). Conclusion Fetuses of individuals with severe maternal anemia demonstrated altered cerebral and umbilical artery flows. Normal flows were restored following treatment of maternal anemia.</description><subject>Anemia - epidemiology</subject><subject>Anemia - therapy</subject><subject>Blood Flow Velocity</subject><subject>Case-Control Studies</subject><subject>Cerebral/umbilical resistance ratio</subject><subject>Doppler velocimetry</subject><subject>Female</subject><subject>Fetus - blood supply</subject><subject>Fetus - diagnostic imaging</subject><subject>Gestational Age</subject><subject>Hemoglobins - analysis</subject><subject>Humans</subject><subject>India</subject><subject>Maternal anemia</subject><subject>Middle cerebral artery</subject><subject>Middle Cerebral Artery - diagnostic imaging</subject><subject>Obstetrics and Gynecology</subject><subject>Parity</subject><subject>Peak systolic velocity</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Hematologic - epidemiology</subject><subject>Pregnancy Complications, Hematologic - therapy</subject><subject>Prospective Studies</subject><subject>Pulsatility index</subject><subject>Resistance index</subject><subject>Severity of Illness Index</subject><subject>Systolic/diastolic ratio</subject><subject>Ultrasonography, Doppler, Color</subject><subject>Umbilical Arteries - diagnostic imaging</subject><subject>Umbilical artery</subject><issn>0020-7292</issn><issn>1879-3479</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk9v1DAQxS0EokvhC3BAPnJJ8DjJJpEQEqroP1XqgfbEwZo4k8ohsRfbWbTfHkdbeuCAevJh3nsa_-Yx9h5EDgK2n8bcjA8ulwKqHCAXAC_YBpq6zYqybl-yjRBSZLVs5Ql7E8IohIAa4DU7kdt2C1XTbNiPc4o48T0GvUzoOfa4ixiNs7yjwXniaHuOQyTPoyeMM9nI3cAD7SlNZ0wTmxLQ0myQG8t3nh4sWn14y14NOAV69_iesvvzb3dnl9nN7cXV2debTJdVW2Zdg0J0fdVUVA19h0RYFrIjLNK6HRRFV1JTVDAI0AJrQMRa1j0NOn2t0Vicso_H3J13vxYKUc0maJqmtJNbgoK6Fa0skjhJ5VGqvQvB06B23szoDwqEWqGqUa1Q1QpVAagENZk-POYv3Uz9k-UvxSSoj4LfZqLDMyLV1fXFrWzK5Px8dFLiszfkVdCGrKbeeNJR9c78f7Mv_9j1ZKzROP2kA4XRLettEgEVpBLq-1qItQ-wTV1oRVn8AVLAr6Y</recordid><startdate>201606</startdate><enddate>201606</enddate><creator>Ali, Eram</creator><creator>Kumar, Manisha</creator><creator>Naqvi, Sayyed E.H</creator><creator>Trivedi, Shubha S</creator><creator>Singh, Anuradha</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201606</creationdate><title>Fetal vascular adaptation before and after treatment of severe maternal anemia in pregnancy</title><author>Ali, Eram ; Kumar, Manisha ; Naqvi, Sayyed E.H ; Trivedi, Shubha S ; Singh, Anuradha</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4594-b8a00bd585e5fdbaeea432bea3017b133b4e8351f01c0a71aaa727defc7298ca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Anemia - epidemiology</topic><topic>Anemia - therapy</topic><topic>Blood Flow Velocity</topic><topic>Case-Control Studies</topic><topic>Cerebral/umbilical resistance ratio</topic><topic>Doppler velocimetry</topic><topic>Female</topic><topic>Fetus - blood supply</topic><topic>Fetus - diagnostic imaging</topic><topic>Gestational Age</topic><topic>Hemoglobins - analysis</topic><topic>Humans</topic><topic>India</topic><topic>Maternal anemia</topic><topic>Middle cerebral artery</topic><topic>Middle Cerebral Artery - diagnostic imaging</topic><topic>Obstetrics and Gynecology</topic><topic>Parity</topic><topic>Peak systolic velocity</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Hematologic - epidemiology</topic><topic>Pregnancy Complications, Hematologic - therapy</topic><topic>Prospective Studies</topic><topic>Pulsatility index</topic><topic>Resistance index</topic><topic>Severity of Illness Index</topic><topic>Systolic/diastolic ratio</topic><topic>Ultrasonography, Doppler, Color</topic><topic>Umbilical Arteries - diagnostic imaging</topic><topic>Umbilical artery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ali, Eram</creatorcontrib><creatorcontrib>Kumar, Manisha</creatorcontrib><creatorcontrib>Naqvi, Sayyed E.H</creatorcontrib><creatorcontrib>Trivedi, Shubha S</creatorcontrib><creatorcontrib>Singh, Anuradha</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of gynecology and obstetrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ali, Eram</au><au>Kumar, Manisha</au><au>Naqvi, Sayyed E.H</au><au>Trivedi, Shubha S</au><au>Singh, Anuradha</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fetal vascular adaptation before and after treatment of severe maternal anemia in pregnancy</atitle><jtitle>International journal of gynecology and obstetrics</jtitle><addtitle>Int J Gynaecol Obstet</addtitle><date>2016-06</date><risdate>2016</risdate><volume>133</volume><issue>3</issue><spage>284</spage><epage>286</epage><pages>284-286</pages><issn>0020-7292</issn><eissn>1879-3479</eissn><abstract>Abstract Objectives To use color Doppler ultrasonography indices to study the effects on fetal circulation of treating severe maternal anemia. Methods A prospective cohort study enrolled patients who were at 30–34 weeks of pregnancy and had hemoglobin levels below 70 g/L between November 1, 2011 and March 31, 2013 at a hospital in New Delhi, India. A control group consisting of patients with the same duration of pregnancy and with hemoglobin levels above 110 g/L was included. Umbilical artery and middle cerebral artery velocimetry were performed using color Doppler ultrasonography at admission and after 4 weeks and 6 weeks of treatment. Results The maternal anemia cohort demonstrated a significantly lower middle cerebral artery resistance index and middle cerebral/umbilical artery resistance ratio ( P < 0.001) at admission. Following 4 weeks of treatment for maternal anemia, significant increases in these parameters were observed ( P < 0.001). Conclusion Fetuses of individuals with severe maternal anemia demonstrated altered cerebral and umbilical artery flows. Normal flows were restored following treatment of maternal anemia.</abstract><cop>United States</cop><pub>Elsevier Ireland Ltd</pub><pmid>26961588</pmid><doi>10.1016/j.ijgo.2015.11.011</doi><tpages>3</tpages></addata></record> |
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| subjects | Anemia - epidemiology Anemia - therapy Blood Flow Velocity Case-Control Studies Cerebral/umbilical resistance ratio Doppler velocimetry Female Fetus - blood supply Fetus - diagnostic imaging Gestational Age Hemoglobins - analysis Humans India Maternal anemia Middle cerebral artery Middle Cerebral Artery - diagnostic imaging Obstetrics and Gynecology Parity Peak systolic velocity Pregnancy Pregnancy Complications, Hematologic - epidemiology Pregnancy Complications, Hematologic - therapy Prospective Studies Pulsatility index Resistance index Severity of Illness Index Systolic/diastolic ratio Ultrasonography, Doppler, Color Umbilical Arteries - diagnostic imaging Umbilical artery |
| title | Fetal vascular adaptation before and after treatment of severe maternal anemia in pregnancy |
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