Lower relapse rates with good post-transplant outcome in alcoholic liver disease: Experience from a living donor liver transplant center
Introduction Post-transplant relapse is a major factor influencing the long-term outcome in alcoholic liver disease (ALD) patients. Aims The aim of this study was to evaluate the relapse rates following living donor liver transplantation (LDLT) in patients with ALD in the Indian context with strong...
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| Veröffentlicht in: | Indian journal of gastroenterology 2016-03, Vol.35 (2), p.123-128 |
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| creator | Saigal, Sanjiv Choudhary, Narendra Singh Yadav, Sanjay Kumar Saraf, Neeraj Kumar, Naveen Rai, Rahul Mehrotra, Saurabh Rastogi, Vipul Rastogi, Amit Goja, Sanjay Bhangui, Prashant Ramachandra, Sumana K. Raut, Vikram Gautam, Dheeraj Soin, Arvinder Singh |
| description | Introduction
Post-transplant relapse is a major factor influencing the long-term outcome in alcoholic liver disease (ALD) patients.
Aims
The aim of this study was to evaluate the relapse rates following living donor liver transplantation (LDLT) in patients with ALD in the Indian context with strong family support.
Methods
Of 458 patients who underwent LDLT for ALD, 408 were included in the study. Post-transplant relapse was determined by information provided by the patient and/or family by means of outpatient and e-mail questionnaire, supported by clinical/biochemical parameters/liver histopathology.
Results
All except one were males, with a mean age of 46.9 ± 8.5 years. The overall rate of relapse was 9.5 % at 34.7 months (interquartile range (IQR) 15–57.6), lower than that reported in the literature from the West. The relapse rate was higher in patients with a shorter duration of pre-transplant abstinence (17.4 % and 15.4 % for recipients with pre-transplant abstinence of |
| doi_str_mv | 10.1007/s12664-016-0646-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1790922752</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1790922752</sourcerecordid><originalsourceid>FETCH-LOGICAL-c344t-4a1e81e99b9e9e3c63c16cc8354761efc6f79a4da99fa629fa6318dac93db9553</originalsourceid><addsrcrecordid>eNp9kctO3DAUhq2qqFDgAdggL7sx2LHjxOwqxKXSSN3A2vI4J4NRYqe2Uy5PwGPjaKaIVTe-yN_55HN-hE4YPWOUNueJVVIKQpkkVApJXr-gA6qamtCGsa_lXNWCtK2k--h7So90uSv-De1XDeNU1PwAva3CE0QcYTBTAhxNhoSfXH7AmxA6PIWUSY7Gp2kwPuMwZxtGwM5jM9jwEAZn8eD-FkXnEpgEF_jqeYLowFvAfQwjNgvg_AZ3wYe4oz85LfgM8Qjt9WZIcLzbD9H99dXd5S1Z_b75dflzRSwXIhNhGLQMlForUMCt5JZJa1tei0Yy6K3sG2VEZ5TqjayWhbO2M1bxbq3qmh-iH1vvFMOfGVLWo0sWhvIVCHPSrFFUVVVTVwVlW9TGkFKEXk_RjSa-aEb1EoDeBqBLAHoJQL-WmtOdfl6P0H1U_Jt4AaotkMqT30DUj2GOvrT8H-s78p2U1A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1790922752</pqid></control><display><type>article</type><title>Lower relapse rates with good post-transplant outcome in alcoholic liver disease: Experience from a living donor liver transplant center</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Saigal, Sanjiv ; Choudhary, Narendra Singh ; Yadav, Sanjay Kumar ; Saraf, Neeraj ; Kumar, Naveen ; Rai, Rahul ; Mehrotra, Saurabh ; Rastogi, Vipul ; Rastogi, Amit ; Goja, Sanjay ; Bhangui, Prashant ; Ramachandra, Sumana K. ; Raut, Vikram ; Gautam, Dheeraj ; Soin, Arvinder Singh</creator><creatorcontrib>Saigal, Sanjiv ; Choudhary, Narendra Singh ; Yadav, Sanjay Kumar ; Saraf, Neeraj ; Kumar, Naveen ; Rai, Rahul ; Mehrotra, Saurabh ; Rastogi, Vipul ; Rastogi, Amit ; Goja, Sanjay ; Bhangui, Prashant ; Ramachandra, Sumana K. ; Raut, Vikram ; Gautam, Dheeraj ; Soin, Arvinder Singh</creatorcontrib><description>Introduction
Post-transplant relapse is a major factor influencing the long-term outcome in alcoholic liver disease (ALD) patients.
Aims
The aim of this study was to evaluate the relapse rates following living donor liver transplantation (LDLT) in patients with ALD in the Indian context with strong family support.
Methods
Of 458 patients who underwent LDLT for ALD, 408 were included in the study. Post-transplant relapse was determined by information provided by the patient and/or family by means of outpatient and e-mail questionnaire, supported by clinical/biochemical parameters/liver histopathology.
Results
All except one were males, with a mean age of 46.9 ± 8.5 years. The overall rate of relapse was 9.5 % at 34.7 months (interquartile range (IQR) 15–57.6), lower than that reported in the literature from the West. The relapse rate was higher in patients with a shorter duration of pre-transplant abstinence (17.4 % and 15.4 % for recipients with pre-transplant abstinence of <3 and <6 months, respectively,
p
< 0.05). The overall survival was 88.5 % at 3 years. Of 39 patients with relapse, 16 (41 %) were occasional drinkers, 14 (35.8 %) were moderate drinkers, and 9 (23 %) were heavy drinkers. All the heavy drinkers presented with features of graft dysfunction.
Conclusions
Good results can be obtained following LDLT for ALD, with significantly lower relapse rates in our setup as compared to the West.</description><identifier>ISSN: 0254-8860</identifier><identifier>EISSN: 0975-0711</identifier><identifier>DOI: 10.1007/s12664-016-0646-z</identifier><identifier>PMID: 27130453</identifier><language>eng</language><publisher>New Delhi: Springer India</publisher><subject>Adult ; Female ; Gastroenterology ; Health Facilities - statistics & numerical data ; Hepatology ; Humans ; India - epidemiology ; Liver Diseases, Alcoholic - epidemiology ; Liver Diseases, Alcoholic - mortality ; Liver Diseases, Alcoholic - surgery ; Liver Transplantation - mortality ; Liver Transplantation - statistics & numerical data ; Living Donors ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Original Article ; Recurrence ; Surveys and Questionnaires ; Survival Rate ; Time Factors ; Treatment Outcome</subject><ispartof>Indian journal of gastroenterology, 2016-03, Vol.35 (2), p.123-128</ispartof><rights>Indian Society of Gastroenterology 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c344t-4a1e81e99b9e9e3c63c16cc8354761efc6f79a4da99fa629fa6318dac93db9553</citedby><cites>FETCH-LOGICAL-c344t-4a1e81e99b9e9e3c63c16cc8354761efc6f79a4da99fa629fa6318dac93db9553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12664-016-0646-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12664-016-0646-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27130453$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saigal, Sanjiv</creatorcontrib><creatorcontrib>Choudhary, Narendra Singh</creatorcontrib><creatorcontrib>Yadav, Sanjay Kumar</creatorcontrib><creatorcontrib>Saraf, Neeraj</creatorcontrib><creatorcontrib>Kumar, Naveen</creatorcontrib><creatorcontrib>Rai, Rahul</creatorcontrib><creatorcontrib>Mehrotra, Saurabh</creatorcontrib><creatorcontrib>Rastogi, Vipul</creatorcontrib><creatorcontrib>Rastogi, Amit</creatorcontrib><creatorcontrib>Goja, Sanjay</creatorcontrib><creatorcontrib>Bhangui, Prashant</creatorcontrib><creatorcontrib>Ramachandra, Sumana K.</creatorcontrib><creatorcontrib>Raut, Vikram</creatorcontrib><creatorcontrib>Gautam, Dheeraj</creatorcontrib><creatorcontrib>Soin, Arvinder Singh</creatorcontrib><title>Lower relapse rates with good post-transplant outcome in alcoholic liver disease: Experience from a living donor liver transplant center</title><title>Indian journal of gastroenterology</title><addtitle>Indian J Gastroenterol</addtitle><addtitle>Indian J Gastroenterol</addtitle><description>Introduction
Post-transplant relapse is a major factor influencing the long-term outcome in alcoholic liver disease (ALD) patients.
Aims
The aim of this study was to evaluate the relapse rates following living donor liver transplantation (LDLT) in patients with ALD in the Indian context with strong family support.
Methods
Of 458 patients who underwent LDLT for ALD, 408 were included in the study. Post-transplant relapse was determined by information provided by the patient and/or family by means of outpatient and e-mail questionnaire, supported by clinical/biochemical parameters/liver histopathology.
Results
All except one were males, with a mean age of 46.9 ± 8.5 years. The overall rate of relapse was 9.5 % at 34.7 months (interquartile range (IQR) 15–57.6), lower than that reported in the literature from the West. The relapse rate was higher in patients with a shorter duration of pre-transplant abstinence (17.4 % and 15.4 % for recipients with pre-transplant abstinence of <3 and <6 months, respectively,
p
< 0.05). The overall survival was 88.5 % at 3 years. Of 39 patients with relapse, 16 (41 %) were occasional drinkers, 14 (35.8 %) were moderate drinkers, and 9 (23 %) were heavy drinkers. All the heavy drinkers presented with features of graft dysfunction.
Conclusions
Good results can be obtained following LDLT for ALD, with significantly lower relapse rates in our setup as compared to the West.</description><subject>Adult</subject><subject>Female</subject><subject>Gastroenterology</subject><subject>Health Facilities - statistics & numerical data</subject><subject>Hepatology</subject><subject>Humans</subject><subject>India - epidemiology</subject><subject>Liver Diseases, Alcoholic - epidemiology</subject><subject>Liver Diseases, Alcoholic - mortality</subject><subject>Liver Diseases, Alcoholic - surgery</subject><subject>Liver Transplantation - mortality</subject><subject>Liver Transplantation - statistics & numerical data</subject><subject>Living Donors</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Original Article</subject><subject>Recurrence</subject><subject>Surveys and Questionnaires</subject><subject>Survival Rate</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><issn>0254-8860</issn><issn>0975-0711</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctO3DAUhq2qqFDgAdggL7sx2LHjxOwqxKXSSN3A2vI4J4NRYqe2Uy5PwGPjaKaIVTe-yN_55HN-hE4YPWOUNueJVVIKQpkkVApJXr-gA6qamtCGsa_lXNWCtK2k--h7So90uSv-De1XDeNU1PwAva3CE0QcYTBTAhxNhoSfXH7AmxA6PIWUSY7Gp2kwPuMwZxtGwM5jM9jwEAZn8eD-FkXnEpgEF_jqeYLowFvAfQwjNgvg_AZ3wYe4oz85LfgM8Qjt9WZIcLzbD9H99dXd5S1Z_b75dflzRSwXIhNhGLQMlForUMCt5JZJa1tei0Yy6K3sG2VEZ5TqjayWhbO2M1bxbq3qmh-iH1vvFMOfGVLWo0sWhvIVCHPSrFFUVVVTVwVlW9TGkFKEXk_RjSa-aEb1EoDeBqBLAHoJQL-WmtOdfl6P0H1U_Jt4AaotkMqT30DUj2GOvrT8H-s78p2U1A</recordid><startdate>20160301</startdate><enddate>20160301</enddate><creator>Saigal, Sanjiv</creator><creator>Choudhary, Narendra Singh</creator><creator>Yadav, Sanjay Kumar</creator><creator>Saraf, Neeraj</creator><creator>Kumar, Naveen</creator><creator>Rai, Rahul</creator><creator>Mehrotra, Saurabh</creator><creator>Rastogi, Vipul</creator><creator>Rastogi, Amit</creator><creator>Goja, Sanjay</creator><creator>Bhangui, Prashant</creator><creator>Ramachandra, Sumana K.</creator><creator>Raut, Vikram</creator><creator>Gautam, Dheeraj</creator><creator>Soin, Arvinder Singh</creator><general>Springer India</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160301</creationdate><title>Lower relapse rates with good post-transplant outcome in alcoholic liver disease: Experience from a living donor liver transplant center</title><author>Saigal, Sanjiv ; Choudhary, Narendra Singh ; Yadav, Sanjay Kumar ; Saraf, Neeraj ; Kumar, Naveen ; Rai, Rahul ; Mehrotra, Saurabh ; Rastogi, Vipul ; Rastogi, Amit ; Goja, Sanjay ; Bhangui, Prashant ; Ramachandra, Sumana K. ; Raut, Vikram ; Gautam, Dheeraj ; Soin, Arvinder Singh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c344t-4a1e81e99b9e9e3c63c16cc8354761efc6f79a4da99fa629fa6318dac93db9553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Female</topic><topic>Gastroenterology</topic><topic>Health Facilities - statistics & numerical data</topic><topic>Hepatology</topic><topic>Humans</topic><topic>India - epidemiology</topic><topic>Liver Diseases, Alcoholic - epidemiology</topic><topic>Liver Diseases, Alcoholic - mortality</topic><topic>Liver Diseases, Alcoholic - surgery</topic><topic>Liver Transplantation - mortality</topic><topic>Liver Transplantation - statistics & numerical data</topic><topic>Living Donors</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Original Article</topic><topic>Recurrence</topic><topic>Surveys and Questionnaires</topic><topic>Survival Rate</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saigal, Sanjiv</creatorcontrib><creatorcontrib>Choudhary, Narendra Singh</creatorcontrib><creatorcontrib>Yadav, Sanjay Kumar</creatorcontrib><creatorcontrib>Saraf, Neeraj</creatorcontrib><creatorcontrib>Kumar, Naveen</creatorcontrib><creatorcontrib>Rai, Rahul</creatorcontrib><creatorcontrib>Mehrotra, Saurabh</creatorcontrib><creatorcontrib>Rastogi, Vipul</creatorcontrib><creatorcontrib>Rastogi, Amit</creatorcontrib><creatorcontrib>Goja, Sanjay</creatorcontrib><creatorcontrib>Bhangui, Prashant</creatorcontrib><creatorcontrib>Ramachandra, Sumana K.</creatorcontrib><creatorcontrib>Raut, Vikram</creatorcontrib><creatorcontrib>Gautam, Dheeraj</creatorcontrib><creatorcontrib>Soin, Arvinder Singh</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Indian journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saigal, Sanjiv</au><au>Choudhary, Narendra Singh</au><au>Yadav, Sanjay Kumar</au><au>Saraf, Neeraj</au><au>Kumar, Naveen</au><au>Rai, Rahul</au><au>Mehrotra, Saurabh</au><au>Rastogi, Vipul</au><au>Rastogi, Amit</au><au>Goja, Sanjay</au><au>Bhangui, Prashant</au><au>Ramachandra, Sumana K.</au><au>Raut, Vikram</au><au>Gautam, Dheeraj</au><au>Soin, Arvinder Singh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lower relapse rates with good post-transplant outcome in alcoholic liver disease: Experience from a living donor liver transplant center</atitle><jtitle>Indian journal of gastroenterology</jtitle><stitle>Indian J Gastroenterol</stitle><addtitle>Indian J Gastroenterol</addtitle><date>2016-03-01</date><risdate>2016</risdate><volume>35</volume><issue>2</issue><spage>123</spage><epage>128</epage><pages>123-128</pages><issn>0254-8860</issn><eissn>0975-0711</eissn><abstract>Introduction
Post-transplant relapse is a major factor influencing the long-term outcome in alcoholic liver disease (ALD) patients.
Aims
The aim of this study was to evaluate the relapse rates following living donor liver transplantation (LDLT) in patients with ALD in the Indian context with strong family support.
Methods
Of 458 patients who underwent LDLT for ALD, 408 were included in the study. Post-transplant relapse was determined by information provided by the patient and/or family by means of outpatient and e-mail questionnaire, supported by clinical/biochemical parameters/liver histopathology.
Results
All except one were males, with a mean age of 46.9 ± 8.5 years. The overall rate of relapse was 9.5 % at 34.7 months (interquartile range (IQR) 15–57.6), lower than that reported in the literature from the West. The relapse rate was higher in patients with a shorter duration of pre-transplant abstinence (17.4 % and 15.4 % for recipients with pre-transplant abstinence of <3 and <6 months, respectively,
p
< 0.05). The overall survival was 88.5 % at 3 years. Of 39 patients with relapse, 16 (41 %) were occasional drinkers, 14 (35.8 %) were moderate drinkers, and 9 (23 %) were heavy drinkers. All the heavy drinkers presented with features of graft dysfunction.
Conclusions
Good results can be obtained following LDLT for ALD, with significantly lower relapse rates in our setup as compared to the West.</abstract><cop>New Delhi</cop><pub>Springer India</pub><pmid>27130453</pmid><doi>10.1007/s12664-016-0646-z</doi><tpages>6</tpages></addata></record> |
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| issn | 0254-8860 0975-0711 |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adult Female Gastroenterology Health Facilities - statistics & numerical data Hepatology Humans India - epidemiology Liver Diseases, Alcoholic - epidemiology Liver Diseases, Alcoholic - mortality Liver Diseases, Alcoholic - surgery Liver Transplantation - mortality Liver Transplantation - statistics & numerical data Living Donors Male Medicine Medicine & Public Health Middle Aged Original Article Recurrence Surveys and Questionnaires Survival Rate Time Factors Treatment Outcome |
| title | Lower relapse rates with good post-transplant outcome in alcoholic liver disease: Experience from a living donor liver transplant center |
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