Lin28A enhances chemosensitivity of colon cancer cells to 5-FU by promoting apoptosis in a let-7 independent manner
RNA-binding protein Lin28A is frequently over-expressed in human malignant tumors and is associated with tumor advance and poor prognosis. However, the expression pattern and functions of Lin28A in colon cancer are unknown. In this study, we detected the expression of Lin28A in colon cancer patients...
Gespeichert in:
| Veröffentlicht in: | Tumor biology 2016-06, Vol.37 (6), p.7657-7665 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 7665 |
|---|---|
| container_issue | 6 |
| container_start_page | 7657 |
| container_title | Tumor biology |
| container_volume | 37 |
| creator | Wang, Tianzhen Han, Peng He, Yan Zhao, Ci Wang, Guangyu Yang, Weiwei Shan, Ming Zhu, Yuanyuan Yang, Chao Weng, Mingjiao Wu, Di Gao, Lin Jin, Xiaoming Wei, Yunwei Cui, BinBin Shen, Guomin Li, Xiaobo |
| description | RNA-binding protein Lin28A is frequently over-expressed in human malignant tumors and is associated with tumor advance and poor prognosis. However, the expression pattern and functions of Lin28A in colon cancer are unknown. In this study, we detected the expression of Lin28A in colon cancer patients and tested the effect of Lin28A on the chemotherapeutic sensitivity of colon cancer cells to 5-fluorouracil (5-FU). As expected, we showed that Lin28A is up-regulated in 73.3 % of colon cancer patients. However, to our surprise, we found that oncogenic protein Lin28A-enforced expression in colon cancer cells enhanced the chemosensitivity of cancer cells to 5-FU via promoting the cell apoptosis. Further mechanisms study revealed that the effect of Lin28A increasing chemosensitivity of cancer cells is in a let-7 independent manner, but which is associated with decreasing the expression of DNA damage repair protein H2AX. Conclusively, here we reported an unexpected function of Lin28A, which may shed lights on fully understanding the physiological and pathological roles of this oncogene. |
| doi_str_mv | 10.1007/s13277-015-4559-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1790922240</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1790922240</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-4b2c1fc71fa2495c3e6a5952963916039d1fa53bb97fd8a6483c7cad5aa15cf53</originalsourceid><addsrcrecordid>eNp1kUtr3TAQhUVoyPsHdFME3WSjVA_LspYhNEnhQjbNWsiynCjYkqvRLdx_H7k3CaXQzczAfHN00EHoM6NXjFL1DZjgShHKJGmk1KQ7QCes4YJQ0dFPdaaMkoZ34hidArzQCmrdHqFj3radUlKfINiEyLtr7OOzjc4Dds9-TuAjhBJ-h7LDacQuTSlitwIZOz9NgEvCktw-4n6Hl5zmVEJ8wnZJS0kQAIeILZ58IaqOg198LbHg2cbo8zk6HO0E_uKtn6HH2-8_b-7J5uHux831hjiheCFNzx0bnWKj5Y2WTvjWSi25boVmLRV6qBsp-l6rcehs23TCKWcHaS2TbpTiDF3udavDX1sPxcwBVvs2-rQFw5SmmnPe0Ip-_Qd9Sdscq7s_FBecylWQ7SmXE0D2o1lymG3eGUbNmojZJ2LqR5s1EdPVmy9vytt-9sPHxXsEFeB7AOoqPvn819P_VX0FiqmV4w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1790232055</pqid></control><display><type>article</type><title>Lin28A enhances chemosensitivity of colon cancer cells to 5-FU by promoting apoptosis in a let-7 independent manner</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Wang, Tianzhen ; Han, Peng ; He, Yan ; Zhao, Ci ; Wang, Guangyu ; Yang, Weiwei ; Shan, Ming ; Zhu, Yuanyuan ; Yang, Chao ; Weng, Mingjiao ; Wu, Di ; Gao, Lin ; Jin, Xiaoming ; Wei, Yunwei ; Cui, BinBin ; Shen, Guomin ; Li, Xiaobo</creator><creatorcontrib>Wang, Tianzhen ; Han, Peng ; He, Yan ; Zhao, Ci ; Wang, Guangyu ; Yang, Weiwei ; Shan, Ming ; Zhu, Yuanyuan ; Yang, Chao ; Weng, Mingjiao ; Wu, Di ; Gao, Lin ; Jin, Xiaoming ; Wei, Yunwei ; Cui, BinBin ; Shen, Guomin ; Li, Xiaobo</creatorcontrib><description>RNA-binding protein Lin28A is frequently over-expressed in human malignant tumors and is associated with tumor advance and poor prognosis. However, the expression pattern and functions of Lin28A in colon cancer are unknown. In this study, we detected the expression of Lin28A in colon cancer patients and tested the effect of Lin28A on the chemotherapeutic sensitivity of colon cancer cells to 5-fluorouracil (5-FU). As expected, we showed that Lin28A is up-regulated in 73.3 % of colon cancer patients. However, to our surprise, we found that oncogenic protein Lin28A-enforced expression in colon cancer cells enhanced the chemosensitivity of cancer cells to 5-FU via promoting the cell apoptosis. Further mechanisms study revealed that the effect of Lin28A increasing chemosensitivity of cancer cells is in a let-7 independent manner, but which is associated with decreasing the expression of DNA damage repair protein H2AX. Conclusively, here we reported an unexpected function of Lin28A, which may shed lights on fully understanding the physiological and pathological roles of this oncogene.</description><identifier>ISSN: 1010-4283</identifier><identifier>EISSN: 1423-0380</identifier><identifier>DOI: 10.1007/s13277-015-4559-8</identifier><identifier>PMID: 26687759</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Adenocarcinoma - drug therapy ; Adenocarcinoma - genetics ; Adenocarcinoma - metabolism ; Adenocarcinoma - pathology ; Adult ; Aged ; Antimetabolites, Antineoplastic - pharmacology ; Apoptosis ; Apoptosis - drug effects ; Apoptosis - genetics ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Colonic Neoplasms - drug therapy ; Colonic Neoplasms - genetics ; Colonic Neoplasms - metabolism ; Colonic Neoplasms - pathology ; Colorectal cancer ; DNA Repair - drug effects ; Drug Resistance, Neoplasm ; Female ; Fluorouracil - pharmacology ; HCT116 Cells ; Histones - biosynthesis ; Histones - genetics ; Humans ; Male ; MicroRNAs - physiology ; Middle Aged ; Neoplasm Proteins - biosynthesis ; Neoplasm Proteins - genetics ; Neoplasm Proteins - physiology ; Original Article ; Proteins ; Recombinant Fusion Proteins - biosynthesis ; Recombinant Fusion Proteins - genetics ; Ribonucleic acid ; RNA ; RNA, Neoplasm - physiology ; RNA-Binding Proteins - biosynthesis ; RNA-Binding Proteins - genetics ; RNA-Binding Proteins - physiology ; Single-Blind Method ; Tumors</subject><ispartof>Tumor biology, 2016-06, Vol.37 (6), p.7657-7665</ispartof><rights>International Society of Oncology and BioMarkers (ISOBM) 2015</rights><rights>International Society of Oncology and BioMarkers (ISOBM) 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-4b2c1fc71fa2495c3e6a5952963916039d1fa53bb97fd8a6483c7cad5aa15cf53</citedby><cites>FETCH-LOGICAL-c372t-4b2c1fc71fa2495c3e6a5952963916039d1fa53bb97fd8a6483c7cad5aa15cf53</cites><orcidid>0000-0003-1037-3903</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s13277-015-4559-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s13277-015-4559-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26687759$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Tianzhen</creatorcontrib><creatorcontrib>Han, Peng</creatorcontrib><creatorcontrib>He, Yan</creatorcontrib><creatorcontrib>Zhao, Ci</creatorcontrib><creatorcontrib>Wang, Guangyu</creatorcontrib><creatorcontrib>Yang, Weiwei</creatorcontrib><creatorcontrib>Shan, Ming</creatorcontrib><creatorcontrib>Zhu, Yuanyuan</creatorcontrib><creatorcontrib>Yang, Chao</creatorcontrib><creatorcontrib>Weng, Mingjiao</creatorcontrib><creatorcontrib>Wu, Di</creatorcontrib><creatorcontrib>Gao, Lin</creatorcontrib><creatorcontrib>Jin, Xiaoming</creatorcontrib><creatorcontrib>Wei, Yunwei</creatorcontrib><creatorcontrib>Cui, BinBin</creatorcontrib><creatorcontrib>Shen, Guomin</creatorcontrib><creatorcontrib>Li, Xiaobo</creatorcontrib><title>Lin28A enhances chemosensitivity of colon cancer cells to 5-FU by promoting apoptosis in a let-7 independent manner</title><title>Tumor biology</title><addtitle>Tumor Biol</addtitle><addtitle>Tumour Biol</addtitle><description>RNA-binding protein Lin28A is frequently over-expressed in human malignant tumors and is associated with tumor advance and poor prognosis. However, the expression pattern and functions of Lin28A in colon cancer are unknown. In this study, we detected the expression of Lin28A in colon cancer patients and tested the effect of Lin28A on the chemotherapeutic sensitivity of colon cancer cells to 5-fluorouracil (5-FU). As expected, we showed that Lin28A is up-regulated in 73.3 % of colon cancer patients. However, to our surprise, we found that oncogenic protein Lin28A-enforced expression in colon cancer cells enhanced the chemosensitivity of cancer cells to 5-FU via promoting the cell apoptosis. Further mechanisms study revealed that the effect of Lin28A increasing chemosensitivity of cancer cells is in a let-7 independent manner, but which is associated with decreasing the expression of DNA damage repair protein H2AX. Conclusively, here we reported an unexpected function of Lin28A, which may shed lights on fully understanding the physiological and pathological roles of this oncogene.</description><subject>Adenocarcinoma - drug therapy</subject><subject>Adenocarcinoma - genetics</subject><subject>Adenocarcinoma - metabolism</subject><subject>Adenocarcinoma - pathology</subject><subject>Adult</subject><subject>Aged</subject><subject>Antimetabolites, Antineoplastic - pharmacology</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Apoptosis - genetics</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Colonic Neoplasms - drug therapy</subject><subject>Colonic Neoplasms - genetics</subject><subject>Colonic Neoplasms - metabolism</subject><subject>Colonic Neoplasms - pathology</subject><subject>Colorectal cancer</subject><subject>DNA Repair - drug effects</subject><subject>Drug Resistance, Neoplasm</subject><subject>Female</subject><subject>Fluorouracil - pharmacology</subject><subject>HCT116 Cells</subject><subject>Histones - biosynthesis</subject><subject>Histones - genetics</subject><subject>Humans</subject><subject>Male</subject><subject>MicroRNAs - physiology</subject><subject>Middle Aged</subject><subject>Neoplasm Proteins - biosynthesis</subject><subject>Neoplasm Proteins - genetics</subject><subject>Neoplasm Proteins - physiology</subject><subject>Original Article</subject><subject>Proteins</subject><subject>Recombinant Fusion Proteins - biosynthesis</subject><subject>Recombinant Fusion Proteins - genetics</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>RNA, Neoplasm - physiology</subject><subject>RNA-Binding Proteins - biosynthesis</subject><subject>RNA-Binding Proteins - genetics</subject><subject>RNA-Binding Proteins - physiology</subject><subject>Single-Blind Method</subject><subject>Tumors</subject><issn>1010-4283</issn><issn>1423-0380</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUtr3TAQhUVoyPsHdFME3WSjVA_LspYhNEnhQjbNWsiynCjYkqvRLdx_H7k3CaXQzczAfHN00EHoM6NXjFL1DZjgShHKJGmk1KQ7QCes4YJQ0dFPdaaMkoZ34hidArzQCmrdHqFj3radUlKfINiEyLtr7OOzjc4Dds9-TuAjhBJ-h7LDacQuTSlitwIZOz9NgEvCktw-4n6Hl5zmVEJ8wnZJS0kQAIeILZ58IaqOg198LbHg2cbo8zk6HO0E_uKtn6HH2-8_b-7J5uHux831hjiheCFNzx0bnWKj5Y2WTvjWSi25boVmLRV6qBsp-l6rcehs23TCKWcHaS2TbpTiDF3udavDX1sPxcwBVvs2-rQFw5SmmnPe0Ip-_Qd9Sdscq7s_FBecylWQ7SmXE0D2o1lymG3eGUbNmojZJ2LqR5s1EdPVmy9vytt-9sPHxXsEFeB7AOoqPvn819P_VX0FiqmV4w</recordid><startdate>20160601</startdate><enddate>20160601</enddate><creator>Wang, Tianzhen</creator><creator>Han, Peng</creator><creator>He, Yan</creator><creator>Zhao, Ci</creator><creator>Wang, Guangyu</creator><creator>Yang, Weiwei</creator><creator>Shan, Ming</creator><creator>Zhu, Yuanyuan</creator><creator>Yang, Chao</creator><creator>Weng, Mingjiao</creator><creator>Wu, Di</creator><creator>Gao, Lin</creator><creator>Jin, Xiaoming</creator><creator>Wei, Yunwei</creator><creator>Cui, BinBin</creator><creator>Shen, Guomin</creator><creator>Li, Xiaobo</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TO</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1037-3903</orcidid></search><sort><creationdate>20160601</creationdate><title>Lin28A enhances chemosensitivity of colon cancer cells to 5-FU by promoting apoptosis in a let-7 independent manner</title><author>Wang, Tianzhen ; Han, Peng ; He, Yan ; Zhao, Ci ; Wang, Guangyu ; Yang, Weiwei ; Shan, Ming ; Zhu, Yuanyuan ; Yang, Chao ; Weng, Mingjiao ; Wu, Di ; Gao, Lin ; Jin, Xiaoming ; Wei, Yunwei ; Cui, BinBin ; Shen, Guomin ; Li, Xiaobo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-4b2c1fc71fa2495c3e6a5952963916039d1fa53bb97fd8a6483c7cad5aa15cf53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adenocarcinoma - drug therapy</topic><topic>Adenocarcinoma - genetics</topic><topic>Adenocarcinoma - metabolism</topic><topic>Adenocarcinoma - pathology</topic><topic>Adult</topic><topic>Aged</topic><topic>Antimetabolites, Antineoplastic - pharmacology</topic><topic>Apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Apoptosis - genetics</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Colonic Neoplasms - drug therapy</topic><topic>Colonic Neoplasms - genetics</topic><topic>Colonic Neoplasms - metabolism</topic><topic>Colonic Neoplasms - pathology</topic><topic>Colorectal cancer</topic><topic>DNA Repair - drug effects</topic><topic>Drug Resistance, Neoplasm</topic><topic>Female</topic><topic>Fluorouracil - pharmacology</topic><topic>HCT116 Cells</topic><topic>Histones - biosynthesis</topic><topic>Histones - genetics</topic><topic>Humans</topic><topic>Male</topic><topic>MicroRNAs - physiology</topic><topic>Middle Aged</topic><topic>Neoplasm Proteins - biosynthesis</topic><topic>Neoplasm Proteins - genetics</topic><topic>Neoplasm Proteins - physiology</topic><topic>Original Article</topic><topic>Proteins</topic><topic>Recombinant Fusion Proteins - biosynthesis</topic><topic>Recombinant Fusion Proteins - genetics</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>RNA, Neoplasm - physiology</topic><topic>RNA-Binding Proteins - biosynthesis</topic><topic>RNA-Binding Proteins - genetics</topic><topic>RNA-Binding Proteins - physiology</topic><topic>Single-Blind Method</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Tianzhen</creatorcontrib><creatorcontrib>Han, Peng</creatorcontrib><creatorcontrib>He, Yan</creatorcontrib><creatorcontrib>Zhao, Ci</creatorcontrib><creatorcontrib>Wang, Guangyu</creatorcontrib><creatorcontrib>Yang, Weiwei</creatorcontrib><creatorcontrib>Shan, Ming</creatorcontrib><creatorcontrib>Zhu, Yuanyuan</creatorcontrib><creatorcontrib>Yang, Chao</creatorcontrib><creatorcontrib>Weng, Mingjiao</creatorcontrib><creatorcontrib>Wu, Di</creatorcontrib><creatorcontrib>Gao, Lin</creatorcontrib><creatorcontrib>Jin, Xiaoming</creatorcontrib><creatorcontrib>Wei, Yunwei</creatorcontrib><creatorcontrib>Cui, BinBin</creatorcontrib><creatorcontrib>Shen, Guomin</creatorcontrib><creatorcontrib>Li, Xiaobo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Tumor biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Tianzhen</au><au>Han, Peng</au><au>He, Yan</au><au>Zhao, Ci</au><au>Wang, Guangyu</au><au>Yang, Weiwei</au><au>Shan, Ming</au><au>Zhu, Yuanyuan</au><au>Yang, Chao</au><au>Weng, Mingjiao</au><au>Wu, Di</au><au>Gao, Lin</au><au>Jin, Xiaoming</au><au>Wei, Yunwei</au><au>Cui, BinBin</au><au>Shen, Guomin</au><au>Li, Xiaobo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lin28A enhances chemosensitivity of colon cancer cells to 5-FU by promoting apoptosis in a let-7 independent manner</atitle><jtitle>Tumor biology</jtitle><stitle>Tumor Biol</stitle><addtitle>Tumour Biol</addtitle><date>2016-06-01</date><risdate>2016</risdate><volume>37</volume><issue>6</issue><spage>7657</spage><epage>7665</epage><pages>7657-7665</pages><issn>1010-4283</issn><eissn>1423-0380</eissn><abstract>RNA-binding protein Lin28A is frequently over-expressed in human malignant tumors and is associated with tumor advance and poor prognosis. However, the expression pattern and functions of Lin28A in colon cancer are unknown. In this study, we detected the expression of Lin28A in colon cancer patients and tested the effect of Lin28A on the chemotherapeutic sensitivity of colon cancer cells to 5-fluorouracil (5-FU). As expected, we showed that Lin28A is up-regulated in 73.3 % of colon cancer patients. However, to our surprise, we found that oncogenic protein Lin28A-enforced expression in colon cancer cells enhanced the chemosensitivity of cancer cells to 5-FU via promoting the cell apoptosis. Further mechanisms study revealed that the effect of Lin28A increasing chemosensitivity of cancer cells is in a let-7 independent manner, but which is associated with decreasing the expression of DNA damage repair protein H2AX. Conclusively, here we reported an unexpected function of Lin28A, which may shed lights on fully understanding the physiological and pathological roles of this oncogene.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>26687759</pmid><doi>10.1007/s13277-015-4559-8</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-1037-3903</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1010-4283 |
| ispartof | Tumor biology, 2016-06, Vol.37 (6), p.7657-7665 |
| issn | 1010-4283 1423-0380 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1790922240 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adenocarcinoma - drug therapy Adenocarcinoma - genetics Adenocarcinoma - metabolism Adenocarcinoma - pathology Adult Aged Antimetabolites, Antineoplastic - pharmacology Apoptosis Apoptosis - drug effects Apoptosis - genetics Biomedical and Life Sciences Biomedicine Cancer Research Colonic Neoplasms - drug therapy Colonic Neoplasms - genetics Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Colorectal cancer DNA Repair - drug effects Drug Resistance, Neoplasm Female Fluorouracil - pharmacology HCT116 Cells Histones - biosynthesis Histones - genetics Humans Male MicroRNAs - physiology Middle Aged Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Neoplasm Proteins - physiology Original Article Proteins Recombinant Fusion Proteins - biosynthesis Recombinant Fusion Proteins - genetics Ribonucleic acid RNA RNA, Neoplasm - physiology RNA-Binding Proteins - biosynthesis RNA-Binding Proteins - genetics RNA-Binding Proteins - physiology Single-Blind Method Tumors |
| title | Lin28A enhances chemosensitivity of colon cancer cells to 5-FU by promoting apoptosis in a let-7 independent manner |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T23%3A44%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Lin28A%20enhances%20chemosensitivity%20of%20colon%20cancer%20cells%20to%205-FU%20by%20promoting%20apoptosis%20in%20a%20let-7%20independent%20manner&rft.jtitle=Tumor%20biology&rft.au=Wang,%20Tianzhen&rft.date=2016-06-01&rft.volume=37&rft.issue=6&rft.spage=7657&rft.epage=7665&rft.pages=7657-7665&rft.issn=1010-4283&rft.eissn=1423-0380&rft_id=info:doi/10.1007/s13277-015-4559-8&rft_dat=%3Cproquest_cross%3E1790922240%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1790232055&rft_id=info:pmid/26687759&rfr_iscdi=true |