Effect of dioxin on ovarian function in the cynomolgus macaque ( M. fascicularis)
Ovarian function was evaluated in mature female cynomolgus macaques 443 to 625 days following a single oral exposure (1, 2, or 4 μg/kg BW) to 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD). Urinary estrone conjugates (E1C), pregnanediol-3-glucuronide (PdG), and follicle stimulating hormone (FSH) were m...
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| Veröffentlicht in: | Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2001-07, Vol.15 (4), p.377-383 |
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| creator | Morán, F.M. Tarara, R. Chen, J. Santos, S. Cheney, A. Overstreet, J.W. Lasley, B.L. |
| description | Ovarian function was evaluated in mature female cynomolgus macaques 443 to 625 days following a single oral exposure (1, 2, or 4 μg/kg BW) to 2,3,7,8-tetrachlorodibenzo-
p-dioxin (TCDD). Urinary estrone conjugates (E1C), pregnanediol-3-glucuronide (PdG), and follicle stimulating hormone (FSH) were measured. Three of four animals in the high dose group had no evidence of menstrual cycles while animals in the low and medium dose groups plus one from the high dose group had cycles that were similar to those of control animals. The noncycling animals had baseline E
1C concentrations without ovulatory midcycle peaks and monotonic PdG profiles. Mean FSH concentrations during the midfollicular phase of the medium dose group and during the entire cycle of the high dose group were elevated compared to those of the control group and the endometria of the noncycling animals were inactive. These data demonstrate that a single exposure of 4 μg/kg BW TCDD leads to long-term adverse effects on ovarian function in primates. |
| doi_str_mv | 10.1016/S0890-6238(01)00138-1 |
| format | Article |
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p-dioxin (TCDD). Urinary estrone conjugates (E1C), pregnanediol-3-glucuronide (PdG), and follicle stimulating hormone (FSH) were measured. Three of four animals in the high dose group had no evidence of menstrual cycles while animals in the low and medium dose groups plus one from the high dose group had cycles that were similar to those of control animals. The noncycling animals had baseline E
1C concentrations without ovulatory midcycle peaks and monotonic PdG profiles. Mean FSH concentrations during the midfollicular phase of the medium dose group and during the entire cycle of the high dose group were elevated compared to those of the control group and the endometria of the noncycling animals were inactive. These data demonstrate that a single exposure of 4 μg/kg BW TCDD leads to long-term adverse effects on ovarian function in primates.</description><identifier>ISSN: 0890-6238</identifier><identifier>EISSN: 1873-1708</identifier><identifier>DOI: 10.1016/S0890-6238(01)00138-1</identifier><identifier>PMID: 11489593</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Administration, Oral ; Animals ; Biological and medical sciences ; Chemical and industrial products toxicology. Toxic occupational diseases ; Dose-Response Relationship, Drug ; Endocrine disruption ; Estradiol - blood ; Estrogen Antagonists - administration & dosage ; Estrogen Antagonists - toxicity ; Estrone - urine ; Female ; Follicle Stimulating Hormone - urine ; Macaca fascicularis ; Macaca fascicularis - blood ; Macaca fascicularis - physiology ; Macaca fascicularis - urine ; Medical sciences ; Menstrual Cycle - drug effects ; Ovary - drug effects ; Ovary - metabolism ; Ovary - pathology ; Polychlorinated Dibenzodioxins - administration & dosage ; Polychlorinated Dibenzodioxins - toxicity ; pregnanediol-3-glucuronide ; Primate ; Progesterone - blood ; Reproduction ; Steroidogenesis ; TCDD ; Time Factors ; Toxicology ; Various organic compounds</subject><ispartof>Reproductive toxicology (Elmsford, N.Y.), 2001-07, Vol.15 (4), p.377-383</ispartof><rights>2001 Elsevier Science Inc.</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-cf1664e77018fab6b7850207674b99b36238a23eb4acab2e31567362d1690bb53</citedby><cites>FETCH-LOGICAL-c421t-cf1664e77018fab6b7850207674b99b36238a23eb4acab2e31567362d1690bb53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0890-6238(01)00138-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,3536,23910,23911,25119,27903,27904,45974</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1084712$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11489593$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Morán, F.M.</creatorcontrib><creatorcontrib>Tarara, R.</creatorcontrib><creatorcontrib>Chen, J.</creatorcontrib><creatorcontrib>Santos, S.</creatorcontrib><creatorcontrib>Cheney, A.</creatorcontrib><creatorcontrib>Overstreet, J.W.</creatorcontrib><creatorcontrib>Lasley, B.L.</creatorcontrib><title>Effect of dioxin on ovarian function in the cynomolgus macaque ( M. fascicularis)</title><title>Reproductive toxicology (Elmsford, N.Y.)</title><addtitle>Reprod Toxicol</addtitle><description>Ovarian function was evaluated in mature female cynomolgus macaques 443 to 625 days following a single oral exposure (1, 2, or 4 μg/kg BW) to 2,3,7,8-tetrachlorodibenzo-
p-dioxin (TCDD). Urinary estrone conjugates (E1C), pregnanediol-3-glucuronide (PdG), and follicle stimulating hormone (FSH) were measured. Three of four animals in the high dose group had no evidence of menstrual cycles while animals in the low and medium dose groups plus one from the high dose group had cycles that were similar to those of control animals. The noncycling animals had baseline E
1C concentrations without ovulatory midcycle peaks and monotonic PdG profiles. Mean FSH concentrations during the midfollicular phase of the medium dose group and during the entire cycle of the high dose group were elevated compared to those of the control group and the endometria of the noncycling animals were inactive. These data demonstrate that a single exposure of 4 μg/kg BW TCDD leads to long-term adverse effects on ovarian function in primates.</description><subject>Administration, Oral</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Dose-Response Relationship, Drug</subject><subject>Endocrine disruption</subject><subject>Estradiol - blood</subject><subject>Estrogen Antagonists - administration & dosage</subject><subject>Estrogen Antagonists - toxicity</subject><subject>Estrone - urine</subject><subject>Female</subject><subject>Follicle Stimulating Hormone - urine</subject><subject>Macaca fascicularis</subject><subject>Macaca fascicularis - blood</subject><subject>Macaca fascicularis - physiology</subject><subject>Macaca fascicularis - urine</subject><subject>Medical sciences</subject><subject>Menstrual Cycle - drug effects</subject><subject>Ovary - drug effects</subject><subject>Ovary - metabolism</subject><subject>Ovary - pathology</subject><subject>Polychlorinated Dibenzodioxins - administration & dosage</subject><subject>Polychlorinated Dibenzodioxins - toxicity</subject><subject>pregnanediol-3-glucuronide</subject><subject>Primate</subject><subject>Progesterone - blood</subject><subject>Reproduction</subject><subject>Steroidogenesis</subject><subject>TCDD</subject><subject>Time Factors</subject><subject>Toxicology</subject><subject>Various organic compounds</subject><issn>0890-6238</issn><issn>1873-1708</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkF1LHTEQhkNp0aP1J7TkooherJ3Zj3xclSJ-FBQpba9Dkk3ayO5Gk13Rf2-O51B7VwgEhmdm3nkI-YBwgoDs8w8QEipWN-II8BgAG1HhG7JCwZsKOYi3ZPUX2SV7Od8CQMsl3yG7iK2QnWxW5PuZ987ONHrah_gYJhrLe9Ap6In6ZbJzKIVSnv84ap-mOMbh95LpqK2-Xxw9otcn1Otsg12G0pWP35N3Xg_ZHWz_ffLr_Ozn6WV1dXPx7fTrVWXbGufKemSsdZwDCq8NM1x0UANnvDVSmmYdW9eNM23ZZGrXYMd4qfbIJBjTNfvkcDP3LsWSJM9qDNm6YdCTi0tWyCUIJlkBuw1oU8w5Oa_uUhh1elIIau1SvbhU640KUL24VFj6Pm4XLGZ0_WvXVl4BPm2Bcr8efNKTDfmf6aLlWBfsywZzxcZDcEkVW26yrg-pqFd9DP9J8gxRHY6R</recordid><startdate>20010701</startdate><enddate>20010701</enddate><creator>Morán, F.M.</creator><creator>Tarara, R.</creator><creator>Chen, J.</creator><creator>Santos, S.</creator><creator>Cheney, A.</creator><creator>Overstreet, J.W.</creator><creator>Lasley, B.L.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20010701</creationdate><title>Effect of dioxin on ovarian function in the cynomolgus macaque ( M. fascicularis)</title><author>Morán, F.M. ; Tarara, R. ; Chen, J. ; Santos, S. ; Cheney, A. ; Overstreet, J.W. ; Lasley, B.L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-cf1664e77018fab6b7850207674b99b36238a23eb4acab2e31567362d1690bb53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Administration, Oral</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Chemical and industrial products toxicology. 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p-dioxin (TCDD). Urinary estrone conjugates (E1C), pregnanediol-3-glucuronide (PdG), and follicle stimulating hormone (FSH) were measured. Three of four animals in the high dose group had no evidence of menstrual cycles while animals in the low and medium dose groups plus one from the high dose group had cycles that were similar to those of control animals. The noncycling animals had baseline E
1C concentrations without ovulatory midcycle peaks and monotonic PdG profiles. Mean FSH concentrations during the midfollicular phase of the medium dose group and during the entire cycle of the high dose group were elevated compared to those of the control group and the endometria of the noncycling animals were inactive. These data demonstrate that a single exposure of 4 μg/kg BW TCDD leads to long-term adverse effects on ovarian function in primates.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>11489593</pmid><doi>10.1016/S0890-6238(01)00138-1</doi><tpages>7</tpages></addata></record> |
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| subjects | Administration, Oral Animals Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Dose-Response Relationship, Drug Endocrine disruption Estradiol - blood Estrogen Antagonists - administration & dosage Estrogen Antagonists - toxicity Estrone - urine Female Follicle Stimulating Hormone - urine Macaca fascicularis Macaca fascicularis - blood Macaca fascicularis - physiology Macaca fascicularis - urine Medical sciences Menstrual Cycle - drug effects Ovary - drug effects Ovary - metabolism Ovary - pathology Polychlorinated Dibenzodioxins - administration & dosage Polychlorinated Dibenzodioxins - toxicity pregnanediol-3-glucuronide Primate Progesterone - blood Reproduction Steroidogenesis TCDD Time Factors Toxicology Various organic compounds |
| title | Effect of dioxin on ovarian function in the cynomolgus macaque ( M. fascicularis) |
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