Comparative in vitro and in vivo cytotoxic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and its arabinosyl derivative, (E)-5-(2-bromovinyl)-1-beta-D-arabinofuranosyluracil (BVaraU), against tumor cells expressing either the Varicella zoster or the Herpes simplex virus thymidine kinase

The inhibitory effects of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and its arabinosyl derivative (E)-5-(2-bromovinyl)-1-beta-D-arabinofuranosyluracil (BVaraU) on the growth of both MDA-MB-435 human breast carcinoma and 9L rat gliosarcoma cells expressing the thymidine kinase (tk)-encoding ge...

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Veröffentlicht in:	Cancer gene therapy 2000-02, Vol.7 (2), p.215-223
Hauptverfasser:	Grignet-Debrus, C, Cool, V, Baudson, N, Degrève, B, Balzarini, J, De Leval, L, Debrus, S, Velu, T, Calberg-Bacq, C M
Format:	Artikel
Sprache:	eng
Schlagworte:	(E)-5-(2-bromovinyl)-1-^b-D-arabinofuranosyluracil (E)-5-(2-bromovinyl)-2'-deoxyuridine Animals Antineoplastic Agents - metabolism Antineoplastic Agents - toxicity Antiviral Agents - metabolism Antiviral Agents - toxicity Arabinofuranosyluracil - analogs & derivatives Arabinofuranosyluracil - toxicity Brain tumors Breast cancer Breast carcinoma Breast Neoplasms - drug therapy Breast Neoplasms - pathology Bromodeoxyuridine - analogs & derivatives Bromodeoxyuridine - metabolism Bromodeoxyuridine - toxicity Chicken pox Cytotoxicity Female Ganciclovir Genetic Vectors Glioma Herpes simplex Herpes simplex virus Herpes viruses Herpesvirus 3, Human - drug effects Herpesvirus 3, Human - enzymology Herpesvirus 3, Human - genetics Humans Kinases Male Mammary gland Mice Mice, Nude Rats Rats, Inbred F344 Simplexvirus - drug effects Simplexvirus - enzymology Simplexvirus - genetics Thymidine Thymidine kinase Thymidine Kinase - biosynthesis Thymidine Kinase - genetics Tumor cells Tumor Cells, Cultured Tumors Varicella Varicella-zoster virus Viruses
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