Different toxicological profile of two COMT inhibitors in vivo: the role of uncoupling effects

The toxicity profiles of entacapone and tolcapone, novel catechol- O-methyl-transferase (COMT) inhibitors, have been reported to differ from each other. It has also been shown that tolcapone, but not entacapone, is a potent uncoupler of oxidative phosphorylation in vitroat low micromolar concentrati...

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Veröffentlicht in:	Journal of Neural Transmission 2002-11, Vol.109 (11), p.1391-1401
Hauptverfasser:	HAASIO, K, NISSINEN, E, SOPANEN, L, HEINONEN, E. H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzophenones - metabolism Benzophenones - toxicity Biological and medical sciences Catechol O-Methyltransferase Inhibitors Catechols - metabolism Catechols - toxicity Drug toxicity and drugs side effects treatment Enzyme Inhibitors - metabolism Enzyme Inhibitors - toxicity Liver - drug effects Liver - metabolism Male Medical sciences Mitochondria, Liver - drug effects Nitriles Nitrophenols Oxidative Phosphorylation - drug effects Pharmacology. Drug treatments Rats Rats, Sprague-Dawley Toxicity: digestive system Uncoupling Agents - metabolism Uncoupling Agents - toxicity
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