Polycations and cationic lipids enhance adenovirus transduction and transgene expression in tumor cells

Replication-deficient adenovirus vectors are efficient vehicles for delivering therapeutic genes into mammalian cells. However, the high doses required to produce effective gene transfer in vivo can also cause unwanted cellular toxicity. To improve replication-deficient adenovirus transgene expressi...

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Veröffentlicht in:	Cancer gene therapy 1999-09, Vol.6 (5), p.437-446
Hauptverfasser:	Clark, P R, Stopeck, A T, Brailey, J L, Wang, Q, McArthur, J, Finer, M H, Hersh, E M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenovirus Adenoviruses Animals Calcium chloride Cations Defective Viruses - genetics Expression vectors Gene transfer Genetic Therapy Humans Immunodeficiency Lipids Lipids - pharmacology lipofectamine Mammalian cells Melanoma Mice Neoplasms - therapy Polybrene Polycations Protamine sulfate Protamines - pharmacology Replication Toxicity Transduction Transduction, Genetic Transgenes Tumor cells Tumor Cells, Cultured β-Galactosidase
Online-Zugang:	Volltext
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