Stromal-Based Signatures for the Classification of Gastric Cancer

Treatment of metastatic gastric cancer typically involves chemotherapy and monoclonal antibodies targeting HER2 (ERBB2) and VEGFR2 (KDR). However, reliable methods to identify patients who would benefit most from a combination of treatment modalities targeting the tumor stroma, including new immunot...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2016-05, Vol.76 (9), p.2573-2586
Hauptverfasser:	Uhlik, Mark T, Liu, Jiangang, Falcon, Beverly L, Iyer, Seema, Stewart, Julie, Celikkaya, Hilal, O'Mahony, Marguerita, Sevinsky, Christopher, Lowes, Christina, Douglass, Larry, Jeffries, Cynthia, Bodenmiller, Diane, Chintharlapalli, Sudhakar, Fischl, Anthony, Gerald, Damien, Xue, Qi, Lee, Jee-Yun, Santamaria-Pang, Alberto, Al-Kofahi, Yousef, Sui, Yunxia, Desai, Keyur, Doman, Thompson, Aggarwal, Amit, Carter, Julia H, Pytowski, Bronislaw, Jaminet, Shou-Ching, Ginty, Fiona, Nasir, Aejaz, Nagy, Janice A, Dvorak, Harold F, Benjamin, Laura E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers, Tumor - analysis Biomarkers, Tumor - genetics Computational Biology - methods Disease Models, Animal Gene Expression Profiling - methods Heterografts Humans Image Processing, Computer-Assisted Immunohistochemistry Mice Neovascularization, Pathologic - genetics Oligonucleotide Array Sequence Analysis Stomach Neoplasms - classification Stomach Neoplasms - genetics Tissue Array Analysis Transcriptome - genetics Tumor Microenvironment - genetics Vascular Endothelial Growth Factor A - metabolism
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