7-(2-Thienyl)-7-Deazaadenosine (AB61), a New Potent Nucleoside Cytostatic with a Complex Mode of Action

7-(2-Thienyl)-7-deazaadenosine (AB61) showed nanomolar cytotoxic activities against various cancer cell lines but only mild (micromolar) activities against normal fibroblasts. The selectivity of AB61 was found to be due to inefficient phosphorylation of AB61 in normal fibroblasts. The phosphorylatio...

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Veröffentlicht in:	Molecular cancer therapeutics 2016-05, Vol.15 (5), p.922-937
Hauptverfasser:	Perlíková, Pavla, Rylová, Gabriela, Nauš, Petr, Elbert, Tomáš, Tloušťová, Eva, Bourderioux, Aurelie, Slavětínská, Lenka Poštová, Motyka, Kamil, Doležal, Dalibor, Znojek, Pawel, Nová, Alice, Harvanová, Monika, Džubák, Petr, Šiller, Michal, Hlaváč, Jan, Hajdúch, Marián, Hocek, Michal
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemistry Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Cell Line, Tumor Cell Membrane Permeability - drug effects Cell Proliferation - drug effects Disease Models, Animal DNA - genetics DNA - metabolism DNA Damage - drug effects Fibroblasts Gene Expression Regulation, Neoplastic Humans Mice Neoplasms - drug therapy Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Protein Biosynthesis - drug effects Protein Folding - drug effects RNA, Messenger - genetics RNA, Messenger - metabolism Survival Analysis Treatment Outcome Tubercidin - analogs & derivatives Tubercidin - chemistry Tubercidin - metabolism Tubercidin - pharmacology Xenograft Model Antitumor Assays
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