ARK5 promotes doxorubicin resistance in hepatocellular carcinoma via epithelial–mesenchymal transition

Highlights • ARK5 overexpression decreases doxorubicin sensitivity in HCC cells. Knockdown of ARK5 could restore the doxorubicin sensitivity. • ARK5 knockdown could up-regulate E-cadherin expression and down-regulate Vimentin expression in HCC cells. • ARK5 could block epithelial-mesenchymal transit...

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Veröffentlicht in:	Cancer letters 2016-07, Vol.377 (2), p.140-148
Hauptverfasser:	Xu, Tao, Zhang, Jian, Chen, Wei, Pan, Shengjing, Zhi, Xiao, Wen, Liang, Zhou, Yue, Chen, Bryan Wei, Qiu, Junyu, Zhang, Yun, Yang, Qi, Feng, Xinhua, Bai, Xueli, Liang, Tingbo
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics, Antineoplastic - pharmacology ARK5 Cadherins - genetics Cadherins - metabolism Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - enzymology Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - pathology Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Chemotherapy Dose-Response Relationship, Drug Doxorubicin - pharmacology Doxorubicin resistance Drug resistance Drug Resistance, Neoplasm EMT Epithelial-Mesenchymal Transition - drug effects HCC Hematology, Oncology and Palliative Medicine Humans Hypoxia Inhibitory Concentration 50 Kinases Liver cancer Liver Neoplasms - drug therapy Liver Neoplasms - enzymology Liver Neoplasms - genetics Liver Neoplasms - pathology Medical prognosis Nuclear Proteins - genetics Nuclear Proteins - metabolism Protein Kinases - genetics Protein Kinases - metabolism Proteins R&D Repressor Proteins - genetics Repressor Proteins - metabolism Research & development RNA Interference Signal Transduction - drug effects Statistical analysis Transfection Tumor Hypoxia Twist-Related Protein 1 - genetics Twist-Related Protein 1 - metabolism Vimentin - genetics Vimentin - metabolism
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Beschreibung
Zusammenfassung:	Highlights • ARK5 overexpression decreases doxorubicin sensitivity in HCC cells. Knockdown of ARK5 could restore the doxorubicin sensitivity. • ARK5 knockdown could up-regulate E-cadherin expression and down-regulate Vimentin expression in HCC cells. • ARK5 could block epithelial-mesenchymal transition induced by doxorubicin.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2016.04.026