Phosphine-mediated Highly Enantioselective Spirocyclization with Ketimines as Substrates

Phosphine‐catalyzed enantioselective annulation reactions involving ketimines are a daunting synthetic challenge owing to the intrinsic low reactivity of ketimine substrates. A highly enantioselective [3+2] cycloaddition reaction that makes use of isatin‐derived ketimines as reaction partners was de...

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Veröffentlicht in:	Angewandte Chemie International Edition 2016-05, Vol.55 (22), p.6492-6496
Hauptverfasser:	Han, Xiaoyu, Chan, Wai-Lun, Yao, Weijun, Wang, Yongjiang, Lu, Yixin
Format:	Artikel
Sprache:	eng
Schlagworte:	[3+2] cycloaddition acyclic ketimines amino acids Chemical reactions Cycloaddition Enantiomers Imines Organic chemistry Phosphine phosphine catalysts spirooxindoles Substrates
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