The role of Eph/ephrin molecules in stromal–hematopoietic interactions
Bone marrow mesenchymal stromal/stem cells (BMSC) are fundamental regulatory elements of the hematopoietic stem cell niche; however, the molecular signals that mediate BMSC support of hematopoiesis are poorly understood. Recent studies indicate that BMSC and hematopoietic stem/progenitors cells diff...
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| Veröffentlicht in: | International journal of hematology 2016-02, Vol.103 (2), p.145-154 |
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| container_title | International journal of hematology |
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| creator | Nguyen, Thao M. Arthur, Agnieszka Gronthos, Stan |
| description | Bone marrow mesenchymal stromal/stem cells (BMSC) are fundamental regulatory elements of the hematopoietic stem cell niche; however, the molecular signals that mediate BMSC support of hematopoiesis are poorly understood. Recent studies indicate that BMSC and hematopoietic stem/progenitors cells differentially express the Eph cell surface tyrosine kinase receptors, and their ephrin ligands. Eph/ephrin interactions are thought to mediate cross-talk between BMSC and different hematopoietic cell populations to influence cell development, migration and function. This review summarizes Eph/ephrin interactions in the regulation of BMSC communication with hematopoietic stem/progenitor cells and discusses Eph/ephrin-targeted therapeutic strategies that are currently being pursued for various hematotological malignancies. |
| doi_str_mv | 10.1007/s12185-015-1886-x |
| format | Article |
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| subjects | Animals Cell Communication - genetics Ephrins - metabolism Ephrins - physiology Hematologic Neoplasms - therapy Hematology Hematopoiesis Hematopoietic Stem Cells - metabolism Hematopoietic Stem Cells - physiology Humans Ligands Medicine Medicine & Public Health Mesenchymal Stromal Cells - metabolism Mesenchymal Stromal Cells - physiology Mice Molecular Targeted Therapy Oncology Progress in Hematology Receptor, EphA1 - metabolism Receptor, EphA1 - physiology |
| title | The role of Eph/ephrin molecules in stromal–hematopoietic interactions |
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