Aberrant local striatal functional connectivity in attention-deficit/hyperactivity disorder

Background Task‐based and resting‐state functional Magnetic Resonance Imaging (fMRI) studies report attention‐deficit/hyperactivity disorder (ADHD)‐related alterations in brain regions implicated in cortico‐striatal networks. We assessed whether ADHD is associated with changes in the brain's gl...

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Veröffentlicht in:Journal of child psychology and psychiatry 2016-06, Vol.57 (6), p.697-705
Hauptverfasser: von Rhein, Daniel, Oldehinkel, Marianne, Beckmann, Christian F., Oosterlaan, Jaap, Heslenfeld, Dirk, Hartman, Catharina A., Hoekstra, Pieter J., Franke, Barbara, Cools, Roshan, Buitelaar, Jan K., Mennes, Maarten
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container_end_page 705
container_issue 6
container_start_page 697
container_title Journal of child psychology and psychiatry
container_volume 57
creator von Rhein, Daniel
Oldehinkel, Marianne
Beckmann, Christian F.
Oosterlaan, Jaap
Heslenfeld, Dirk
Hartman, Catharina A.
Hoekstra, Pieter J.
Franke, Barbara
Cools, Roshan
Buitelaar, Jan K.
Mennes, Maarten
description Background Task‐based and resting‐state functional Magnetic Resonance Imaging (fMRI) studies report attention‐deficit/hyperactivity disorder (ADHD)‐related alterations in brain regions implicated in cortico‐striatal networks. We assessed whether ADHD is associated with changes in the brain's global cortico‐striatal functional architecture, or whether ADHD‐related alterations are limited to local, intrastriatal functional connections. Methods We included a cohort of adolescents with ADHD (N = 181) and healthy controls (N = 140) and assessed functional connectivity of nucleus accumbens, caudate nucleus, anterior putamen, and posterior putamen. To assess global cortico‐striatal functional architecture we computed whole‐brain functional connectivity by including all regions of interest in one multivariate analysis. We assessed local striatal functional connectivity using partial correlations between the time series of the striatal regions. Results Diagnostic status did not influence global cortico‐striatal functional architecture. However, compared to controls, participants with ADHD exhibited significantly increased local functional connectivity between anterior and posterior putamen (p = .0003; ADHD: z = .30, controls: z = .24). Results were not affected by medication use or comorbid oppositional defiant disorder and conduct disorder. Conclusions Our results do not support hypotheses that ADHD is associated with alterations in cortico‐striatal networks, but suggest changes in local striatal functional connectivity. We interpret our findings as aberrant development of local functional connectivity of the putamen, potentially leading to decreased functional segregation between anterior and posterior putamen in ADHD.
doi_str_mv 10.1111/jcpp.12529
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We assessed whether ADHD is associated with changes in the brain's global cortico‐striatal functional architecture, or whether ADHD‐related alterations are limited to local, intrastriatal functional connections. Methods We included a cohort of adolescents with ADHD (N = 181) and healthy controls (N = 140) and assessed functional connectivity of nucleus accumbens, caudate nucleus, anterior putamen, and posterior putamen. To assess global cortico‐striatal functional architecture we computed whole‐brain functional connectivity by including all regions of interest in one multivariate analysis. We assessed local striatal functional connectivity using partial correlations between the time series of the striatal regions. Results Diagnostic status did not influence global cortico‐striatal functional architecture. However, compared to controls, participants with ADHD exhibited significantly increased local functional connectivity between anterior and posterior putamen (p = .0003; ADHD: z = .30, controls: z = .24). Results were not affected by medication use or comorbid oppositional defiant disorder and conduct disorder. Conclusions Our results do not support hypotheses that ADHD is associated with alterations in cortico‐striatal networks, but suggest changes in local striatal functional connectivity. We interpret our findings as aberrant development of local functional connectivity of the putamen, potentially leading to decreased functional segregation between anterior and posterior putamen in ADHD.</description><identifier>ISSN: 0021-9630</identifier><identifier>EISSN: 1469-7610</identifier><identifier>DOI: 10.1111/jcpp.12529</identifier><identifier>PMID: 26871610</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Architecture ; Attention Deficit Disorder with Hyperactivity - physiopathology ; Attention deficit hyperactivity disorder ; Brain ; Cerebral Cortex - physiopathology ; Child ; Child psychology ; Comorbidity ; Conduct disordered adolescents ; Control Groups ; Corpus Striatum - physiopathology ; cortico-striatal networks ; Drug Use ; Drugs ; Female ; Functional connectivity ; Functional magnetic resonance imaging ; Humans ; Magnetic Resonance Imaging ; Male ; Multivariate analysis ; Nerve Net - physiopathology ; Neuropsychology ; NMR ; Nuclear magnetic resonance ; Oppositional defiant disorder ; putamen ; Resting ; Resting-state fMRI ; Segregation ; striatum ; Time series</subject><ispartof>Journal of child psychology and psychiatry, 2016-06, Vol.57 (6), p.697-705</ispartof><rights>2016 Association for Child and Adolescent Mental Health.</rights><rights>Copyright © 2016 Association for Child and Adolescent Mental Health.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4659-8ec724a06162870e2f81b88128e193b6082baea78b23ef30ac1aee82266e981f3</citedby><cites>FETCH-LOGICAL-c4659-8ec724a06162870e2f81b88128e193b6082baea78b23ef30ac1aee82266e981f3</cites><orcidid>0000-0001-8288-7757</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjcpp.12529$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjcpp.12529$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,30999,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26871610$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>von Rhein, Daniel</creatorcontrib><creatorcontrib>Oldehinkel, Marianne</creatorcontrib><creatorcontrib>Beckmann, Christian F.</creatorcontrib><creatorcontrib>Oosterlaan, Jaap</creatorcontrib><creatorcontrib>Heslenfeld, Dirk</creatorcontrib><creatorcontrib>Hartman, Catharina A.</creatorcontrib><creatorcontrib>Hoekstra, Pieter J.</creatorcontrib><creatorcontrib>Franke, Barbara</creatorcontrib><creatorcontrib>Cools, Roshan</creatorcontrib><creatorcontrib>Buitelaar, Jan K.</creatorcontrib><creatorcontrib>Mennes, Maarten</creatorcontrib><title>Aberrant local striatal functional connectivity in attention-deficit/hyperactivity disorder</title><title>Journal of child psychology and psychiatry</title><addtitle>J Child Psychol Psychiatr</addtitle><description>Background Task‐based and resting‐state functional Magnetic Resonance Imaging (fMRI) studies report attention‐deficit/hyperactivity disorder (ADHD)‐related alterations in brain regions implicated in cortico‐striatal networks. We assessed whether ADHD is associated with changes in the brain's global cortico‐striatal functional architecture, or whether ADHD‐related alterations are limited to local, intrastriatal functional connections. Methods We included a cohort of adolescents with ADHD (N = 181) and healthy controls (N = 140) and assessed functional connectivity of nucleus accumbens, caudate nucleus, anterior putamen, and posterior putamen. To assess global cortico‐striatal functional architecture we computed whole‐brain functional connectivity by including all regions of interest in one multivariate analysis. We assessed local striatal functional connectivity using partial correlations between the time series of the striatal regions. Results Diagnostic status did not influence global cortico‐striatal functional architecture. However, compared to controls, participants with ADHD exhibited significantly increased local functional connectivity between anterior and posterior putamen (p = .0003; ADHD: z = .30, controls: z = .24). Results were not affected by medication use or comorbid oppositional defiant disorder and conduct disorder. Conclusions Our results do not support hypotheses that ADHD is associated with alterations in cortico‐striatal networks, but suggest changes in local striatal functional connectivity. 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Oldehinkel, Marianne ; Beckmann, Christian F. ; Oosterlaan, Jaap ; Heslenfeld, Dirk ; Hartman, Catharina A. ; Hoekstra, Pieter J. ; Franke, Barbara ; Cools, Roshan ; Buitelaar, Jan K. ; Mennes, Maarten</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4659-8ec724a06162870e2f81b88128e193b6082baea78b23ef30ac1aee82266e981f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Architecture</topic><topic>Attention Deficit Disorder with Hyperactivity - physiopathology</topic><topic>Attention deficit hyperactivity disorder</topic><topic>Brain</topic><topic>Cerebral Cortex - physiopathology</topic><topic>Child</topic><topic>Child psychology</topic><topic>Comorbidity</topic><topic>Conduct disordered adolescents</topic><topic>Control Groups</topic><topic>Corpus Striatum - physiopathology</topic><topic>cortico-striatal networks</topic><topic>Drug Use</topic><topic>Drugs</topic><topic>Female</topic><topic>Functional connectivity</topic><topic>Functional magnetic resonance imaging</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Multivariate analysis</topic><topic>Nerve Net - physiopathology</topic><topic>Neuropsychology</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Oppositional defiant disorder</topic><topic>putamen</topic><topic>Resting</topic><topic>Resting-state fMRI</topic><topic>Segregation</topic><topic>striatum</topic><topic>Time series</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>von Rhein, Daniel</creatorcontrib><creatorcontrib>Oldehinkel, Marianne</creatorcontrib><creatorcontrib>Beckmann, Christian F.</creatorcontrib><creatorcontrib>Oosterlaan, Jaap</creatorcontrib><creatorcontrib>Heslenfeld, Dirk</creatorcontrib><creatorcontrib>Hartman, Catharina A.</creatorcontrib><creatorcontrib>Hoekstra, Pieter J.</creatorcontrib><creatorcontrib>Franke, Barbara</creatorcontrib><creatorcontrib>Cools, Roshan</creatorcontrib><creatorcontrib>Buitelaar, Jan K.</creatorcontrib><creatorcontrib>Mennes, Maarten</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Applied Social Sciences Index &amp; 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We assessed whether ADHD is associated with changes in the brain's global cortico‐striatal functional architecture, or whether ADHD‐related alterations are limited to local, intrastriatal functional connections. Methods We included a cohort of adolescents with ADHD (N = 181) and healthy controls (N = 140) and assessed functional connectivity of nucleus accumbens, caudate nucleus, anterior putamen, and posterior putamen. To assess global cortico‐striatal functional architecture we computed whole‐brain functional connectivity by including all regions of interest in one multivariate analysis. We assessed local striatal functional connectivity using partial correlations between the time series of the striatal regions. Results Diagnostic status did not influence global cortico‐striatal functional architecture. However, compared to controls, participants with ADHD exhibited significantly increased local functional connectivity between anterior and posterior putamen (p = .0003; ADHD: z = .30, controls: z = .24). Results were not affected by medication use or comorbid oppositional defiant disorder and conduct disorder. Conclusions Our results do not support hypotheses that ADHD is associated with alterations in cortico‐striatal networks, but suggest changes in local striatal functional connectivity. We interpret our findings as aberrant development of local functional connectivity of the putamen, potentially leading to decreased functional segregation between anterior and posterior putamen in ADHD.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>26871610</pmid><doi>10.1111/jcpp.12529</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-8288-7757</orcidid></addata></record>
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subjects Adolescent
Architecture
Attention Deficit Disorder with Hyperactivity - physiopathology
Attention deficit hyperactivity disorder
Brain
Cerebral Cortex - physiopathology
Child
Child psychology
Comorbidity
Conduct disordered adolescents
Control Groups
Corpus Striatum - physiopathology
cortico-striatal networks
Drug Use
Drugs
Female
Functional connectivity
Functional magnetic resonance imaging
Humans
Magnetic Resonance Imaging
Male
Multivariate analysis
Nerve Net - physiopathology
Neuropsychology
NMR
Nuclear magnetic resonance
Oppositional defiant disorder
putamen
Resting
Resting-state fMRI
Segregation
striatum
Time series
title Aberrant local striatal functional connectivity in attention-deficit/hyperactivity disorder
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