Visible Light-Controlled Nitric Oxide Release from Hindered Nitrobenzene Derivatives for Specific Modulation of Mitochondrial Dynamics

Nitric oxide (NO) is a physiological signaling molecule, whose biological production is precisely regulated at the subcellular level. Here, we describe the design, synthesis, and evaluation of novel mitochondria-targeted NO releasers, Rol-DNB-mor and Rol-DNB-pyr, that are photocontrollable not only...

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Veröffentlicht in:	ACS chemical biology 2016-05, Vol.11 (5), p.1271-1278
Hauptverfasser:	Kitamura, Kai, Kawaguchi, Mitsuyasu, Ieda, Naoya, Miyata, Naoki, Nakagawa, Hidehiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Coloring Agents - chemistry Coloring Agents - pharmacology HCT116 Cells HEK293 Cells Humans Light Mitochondrial Dynamics - drug effects Nitric Oxide - chemistry Nitric Oxide - pharmacology Nitric Oxide Donors - chemistry Nitric Oxide Donors - pharmacology Nitrobenzenes - chemistry Nitrobenzenes - pharmacology Rhodamines - chemistry Rhodamines - pharmacology
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