Postoperative Anemia Is Associated with Acute Kidney Injury in Patients Undergoing Total Hip Replacement Arthroplasty: A Retrospective Study
BACKGROUND:Chronic and acute anemia are both correlated with an increased risk of injury to major organs, such as the brain, heart, and kidney. We evaluated the association between postoperative anemia (hemoglobin [Hb] < 10 g/dL) and acute kidney injury (AKI) in patients undergoing total hip repl...
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| Veröffentlicht in: | Anesthesia and analgesia 2016-06, Vol.122 (6), p.1923-1928 |
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| creator | Choi, Yoon Ji Kim, Seon-Ok Sim, Ji Hoon Hahm, Kyung-Don |
| description | BACKGROUND:Chronic and acute anemia are both correlated with an increased risk of injury to major organs, such as the brain, heart, and kidney. We evaluated the association between postoperative anemia (hemoglobin [Hb] < 10 g/dL) and acute kidney injury (AKI) in patients undergoing total hip replacement arthroplasty (THRA).
METHODS:Patients who underwent THRA between January 2005 and February 2013 were retrospectively reviewed. We divided patients into 2 groupsHb < 10 (n = 938) and Hb ≥ 10 (n = 1529). They were then categorized according to changes in plasma creatinine concentration within 48 hours of THRA using Acute Kidney Injury Network criteria. To evaluate the association between postoperative anemia and postoperative AKI, an inverse-probability-of-treatment weighted method was used and both univariate and multivariable analyses were performed.
RESULTS:Postoperative anemia was significantly associated with postoperative AKI (multivariate odds ratio, 2.036; 95% confidence interval, 1.369–3.028; P < 0.001; inverse probability-of-treatment weighted odds ratio, 1.817; 95% confidence interval, 1.169–2.826; P = 0.011). In patients with a normal glomerular filtration rate, postoperative AKI was also related to postoperative anemia (P = 0.010).
CONCLUSIONS:Postoperative anemia was associated with postoperative AKI after THRA. Although our study was limited by its retrospective design, our observation suggests that postoperative anemia may play a role in postoperative AKI. |
| doi_str_mv | 10.1213/ANE.0000000000001003 |
| format | Article |
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METHODS:Patients who underwent THRA between January 2005 and February 2013 were retrospectively reviewed. We divided patients into 2 groupsHb < 10 (n = 938) and Hb ≥ 10 (n = 1529). They were then categorized according to changes in plasma creatinine concentration within 48 hours of THRA using Acute Kidney Injury Network criteria. To evaluate the association between postoperative anemia and postoperative AKI, an inverse-probability-of-treatment weighted method was used and both univariate and multivariable analyses were performed.
RESULTS:Postoperative anemia was significantly associated with postoperative AKI (multivariate odds ratio, 2.036; 95% confidence interval, 1.369–3.028; P < 0.001; inverse probability-of-treatment weighted odds ratio, 1.817; 95% confidence interval, 1.169–2.826; P = 0.011). In patients with a normal glomerular filtration rate, postoperative AKI was also related to postoperative anemia (P = 0.010).
CONCLUSIONS:Postoperative anemia was associated with postoperative AKI after THRA. Although our study was limited by its retrospective design, our observation suggests that postoperative anemia may play a role in postoperative AKI.</description><identifier>ISSN: 0003-2999</identifier><identifier>EISSN: 1526-7598</identifier><identifier>DOI: 10.1213/ANE.0000000000001003</identifier><identifier>PMID: 26451518</identifier><language>eng</language><publisher>United States: International Anesthesia Research Society</publisher><subject>Acute Kidney Injury - blood ; Acute Kidney Injury - diagnosis ; Acute Kidney Injury - etiology ; Aged ; Anemia - blood ; Anemia - diagnosis ; Anemia - etiology ; Arthroplasty, Replacement, Hip - adverse effects ; Biomarkers - blood ; Chi-Square Distribution ; Creatinine - blood ; Female ; Hemoglobins - analysis ; Humans ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; Odds Ratio ; Propensity Score ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Time Factors ; Treatment Outcome</subject><ispartof>Anesthesia and analgesia, 2016-06, Vol.122 (6), p.1923-1928</ispartof><rights>International Anesthesia Research Society</rights><rights>2016 International Anesthesia Research Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4013-c2d75556af5582fc6ec192afe24683a60a42f6cb8131ed80e2ca954cef9263013</citedby><cites>FETCH-LOGICAL-c4013-c2d75556af5582fc6ec192afe24683a60a42f6cb8131ed80e2ca954cef9263013</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=00000539-201606000-00031$$EHTML$$P50$$Gwolterskluwer$$H</linktohtml><link.rule.ids>314,776,780,4594,27903,27904,65209</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26451518$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Choi, Yoon Ji</creatorcontrib><creatorcontrib>Kim, Seon-Ok</creatorcontrib><creatorcontrib>Sim, Ji Hoon</creatorcontrib><creatorcontrib>Hahm, Kyung-Don</creatorcontrib><title>Postoperative Anemia Is Associated with Acute Kidney Injury in Patients Undergoing Total Hip Replacement Arthroplasty: A Retrospective Study</title><title>Anesthesia and analgesia</title><addtitle>Anesth Analg</addtitle><description>BACKGROUND:Chronic and acute anemia are both correlated with an increased risk of injury to major organs, such as the brain, heart, and kidney. We evaluated the association between postoperative anemia (hemoglobin [Hb] < 10 g/dL) and acute kidney injury (AKI) in patients undergoing total hip replacement arthroplasty (THRA).
METHODS:Patients who underwent THRA between January 2005 and February 2013 were retrospectively reviewed. We divided patients into 2 groupsHb < 10 (n = 938) and Hb ≥ 10 (n = 1529). They were then categorized according to changes in plasma creatinine concentration within 48 hours of THRA using Acute Kidney Injury Network criteria. To evaluate the association between postoperative anemia and postoperative AKI, an inverse-probability-of-treatment weighted method was used and both univariate and multivariable analyses were performed.
RESULTS:Postoperative anemia was significantly associated with postoperative AKI (multivariate odds ratio, 2.036; 95% confidence interval, 1.369–3.028; P < 0.001; inverse probability-of-treatment weighted odds ratio, 1.817; 95% confidence interval, 1.169–2.826; P = 0.011). In patients with a normal glomerular filtration rate, postoperative AKI was also related to postoperative anemia (P = 0.010).
CONCLUSIONS:Postoperative anemia was associated with postoperative AKI after THRA. Although our study was limited by its retrospective design, our observation suggests that postoperative anemia may play a role in postoperative AKI.</description><subject>Acute Kidney Injury - blood</subject><subject>Acute Kidney Injury - diagnosis</subject><subject>Acute Kidney Injury - etiology</subject><subject>Aged</subject><subject>Anemia - blood</subject><subject>Anemia - diagnosis</subject><subject>Anemia - etiology</subject><subject>Arthroplasty, Replacement, Hip - adverse effects</subject><subject>Biomarkers - blood</subject><subject>Chi-Square Distribution</subject><subject>Creatinine - blood</subject><subject>Female</subject><subject>Hemoglobins - analysis</subject><subject>Humans</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Odds Ratio</subject><subject>Propensity Score</subject><subject>Retrospective Studies</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><issn>0003-2999</issn><issn>1526-7598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks1u1DAUhS0EokPhDRDykk2K_8dmF1WFjqiggnYduc5NxyWJg-0wyjvw0LgzBSEW4I11r79zruVjhF5SckIZ5W_qj2cn5I9FCeGP0IpKpqq1NPoxWpUur5gx5gg9S-luD2n1FB0xJSSVVK_Qj8uQcpgg2uy_A65HGLzFm4TrlILzNkOLdz5vce3mDPiDb0dY8Ga8m-OC_Ygviw7GnPD12EK8DX68xVch2x6f-wl_hqm3DoZC4DrmbQylTnl5i-tylmNIE7j94C95bpfn6Eln-wQvHvZjdP3u7Or0vLr49H5zWl9UThDKK8fatZRS2U5KzTqnwFHDbAdMKM2tIlawTrkbTTmFVhNgzhopHHSGKV4cjtHrg-8Uw7cZUm4Gnxz0vR0hzKmha0OEFEbzgooD6splU4SumaIfbFwaSpr7HJqSQ_N3DkX26mHCfDNA-1v06-ELoA_ALvQZYvrazzuIzRZsn7f_8xb_kO45yU3FCFVElaK6_waU_wQn0KVH</recordid><startdate>20160601</startdate><enddate>20160601</enddate><creator>Choi, Yoon Ji</creator><creator>Kim, Seon-Ok</creator><creator>Sim, Ji Hoon</creator><creator>Hahm, Kyung-Don</creator><general>International Anesthesia Research Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160601</creationdate><title>Postoperative Anemia Is Associated with Acute Kidney Injury in Patients Undergoing Total Hip Replacement Arthroplasty: A Retrospective Study</title><author>Choi, Yoon Ji ; Kim, Seon-Ok ; Sim, Ji Hoon ; Hahm, Kyung-Don</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4013-c2d75556af5582fc6ec192afe24683a60a42f6cb8131ed80e2ca954cef9263013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Acute Kidney Injury - blood</topic><topic>Acute Kidney Injury - diagnosis</topic><topic>Acute Kidney Injury - etiology</topic><topic>Aged</topic><topic>Anemia - blood</topic><topic>Anemia - diagnosis</topic><topic>Anemia - etiology</topic><topic>Arthroplasty, Replacement, Hip - adverse effects</topic><topic>Biomarkers - blood</topic><topic>Chi-Square Distribution</topic><topic>Creatinine - blood</topic><topic>Female</topic><topic>Hemoglobins - analysis</topic><topic>Humans</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Odds Ratio</topic><topic>Propensity Score</topic><topic>Retrospective Studies</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Choi, Yoon Ji</creatorcontrib><creatorcontrib>Kim, Seon-Ok</creatorcontrib><creatorcontrib>Sim, Ji Hoon</creatorcontrib><creatorcontrib>Hahm, Kyung-Don</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Anesthesia and analgesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Choi, Yoon Ji</au><au>Kim, Seon-Ok</au><au>Sim, Ji Hoon</au><au>Hahm, Kyung-Don</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Postoperative Anemia Is Associated with Acute Kidney Injury in Patients Undergoing Total Hip Replacement Arthroplasty: A Retrospective Study</atitle><jtitle>Anesthesia and analgesia</jtitle><addtitle>Anesth Analg</addtitle><date>2016-06-01</date><risdate>2016</risdate><volume>122</volume><issue>6</issue><spage>1923</spage><epage>1928</epage><pages>1923-1928</pages><issn>0003-2999</issn><eissn>1526-7598</eissn><abstract>BACKGROUND:Chronic and acute anemia are both correlated with an increased risk of injury to major organs, such as the brain, heart, and kidney. We evaluated the association between postoperative anemia (hemoglobin [Hb] < 10 g/dL) and acute kidney injury (AKI) in patients undergoing total hip replacement arthroplasty (THRA).
METHODS:Patients who underwent THRA between January 2005 and February 2013 were retrospectively reviewed. We divided patients into 2 groupsHb < 10 (n = 938) and Hb ≥ 10 (n = 1529). They were then categorized according to changes in plasma creatinine concentration within 48 hours of THRA using Acute Kidney Injury Network criteria. To evaluate the association between postoperative anemia and postoperative AKI, an inverse-probability-of-treatment weighted method was used and both univariate and multivariable analyses were performed.
RESULTS:Postoperative anemia was significantly associated with postoperative AKI (multivariate odds ratio, 2.036; 95% confidence interval, 1.369–3.028; P < 0.001; inverse probability-of-treatment weighted odds ratio, 1.817; 95% confidence interval, 1.169–2.826; P = 0.011). In patients with a normal glomerular filtration rate, postoperative AKI was also related to postoperative anemia (P = 0.010).
CONCLUSIONS:Postoperative anemia was associated with postoperative AKI after THRA. Although our study was limited by its retrospective design, our observation suggests that postoperative anemia may play a role in postoperative AKI.</abstract><cop>United States</cop><pub>International Anesthesia Research Society</pub><pmid>26451518</pmid><doi>10.1213/ANE.0000000000001003</doi><tpages>6</tpages></addata></record> |
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| subjects | Acute Kidney Injury - blood Acute Kidney Injury - diagnosis Acute Kidney Injury - etiology Aged Anemia - blood Anemia - diagnosis Anemia - etiology Arthroplasty, Replacement, Hip - adverse effects Biomarkers - blood Chi-Square Distribution Creatinine - blood Female Hemoglobins - analysis Humans Logistic Models Male Middle Aged Multivariate Analysis Odds Ratio Propensity Score Retrospective Studies Risk Assessment Risk Factors Time Factors Treatment Outcome |
| title | Postoperative Anemia Is Associated with Acute Kidney Injury in Patients Undergoing Total Hip Replacement Arthroplasty: A Retrospective Study |
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