The effects of a 5-HT5A receptor antagonist in a ketamine-based rat model of cognitive dysfunction and the negative symptoms of schizophrenia

Serotonin (5-HT) receptors still represent promising targets for the development of novel multireceptor or stand-alone antipsychotic drugs with a potential to ameliorate cognitive impairments and negative symptoms in schizophrenia. The 5-HT5A receptor, one of the least known members of the serotonin...

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Veröffentlicht in:	Neuropharmacology 2016-06, Vol.105, p.351-360
Hauptverfasser:	Nikiforuk, Agnieszka, Hołuj, Małgorzata, Kos, Tomasz, Popik, Piotr
Format:	Artikel
Sprache:	eng
Schlagworte:	5-HT5A receptor Animal models Animals Asociality Choice Behavior - drug effects Cognition Cognitive Dysfunction - chemically induced Cognitive Dysfunction - drug therapy Cognitive Dysfunction - psychology Cognitive flexibility Excitatory Amino Acid Antagonists Interpersonal Relations Ketamine Male NMDA receptor Nootropic Agents - pharmacology Rats Rats, Sprague-Dawley Receptors, Serotonin - drug effects Recognition (Psychology) - drug effects Schizophrenia - chemically induced Schizophrenia - drug therapy Schizophrenic Psychology Serotonin Antagonists - pharmacology Social Behavior
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