The periconception maternal cardiovascular risk profile influences human embryonic growth trajectories in IVF/ICSI pregnancies
Abstract STUDY QUESTION Is the maternal cardiovascular (CV) risk profile associated with human embryonic growth trajectories and does the mode of conception affect this association? SUMMARY ANSWER This small study suggests that the maternal CV risk profile is inversely associated with first trimeste...
Gespeichert in:
| Veröffentlicht in: | Human reproduction (Oxford) 2016-06, Vol.31 (6), p.1173-1181 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1181 |
|---|---|
| container_issue | 6 |
| container_start_page | 1173 |
| container_title | Human reproduction (Oxford) |
| container_volume | 31 |
| creator | Wijnands, K.P.J. van Uitert, E.M. Roeters van Lennep, J.E. Koning, A.H.J. Mulders, A.G.M.G.J. Laven, J.S.E. Steegers, E.A.P. Steegers-Theunissen, R.P.M. |
| description | Abstract
STUDY QUESTION
Is the maternal cardiovascular (CV) risk profile associated with human embryonic growth trajectories and does the mode of conception affect this association?
SUMMARY ANSWER
This small study suggests that the maternal CV risk profile is inversely associated with first trimester embryonic growth trajectories in in vitro fertilization (IVF)/intra-cytoplasmic sperm injection (ICSI) pregnancies, but not in spontaneously conceived pregnancies.
WHAT IS KNOWN ALREADY
Maternal high-blood pressure and smoking affect placental function, accompanied by increased risk of fetal growth restriction and low-birthweight. Mothers who experience pregnancies complicated by fetal growth restriction are at increased risk of CV disease in later life.
STUDY DESIGN, SIZE, DURATION
In a prospective periconception birth cohort conducted in a tertiary hospital, 111 singleton ongoing pregnancies with reliable pregnancy dating, no pre-existing maternal disease and no malformed live borns were investigated.
PARTICIPANTS/MATERIALS, SETTINGS, METHODS
Spontaneously conceived pregnancies with a reliable first day of the last menstrual period and a regular menstrual cycle of 25–31 days only (n = 66) and IVF/ICSI pregnancies (n = 45) were included. Women underwent weekly three-dimensional ultrasound scans (3D US) from 6- to 13-week gestational age. To estimate embryonic growth, serial crown-rump length (CRL) measurements were performed using the V-Scope software in a BARCO I-Space. Maternal characteristics and CV risk factors were collected by self-administered questionnaires. The CV risk profile was created based on a score of risk factors, including maternal age, body-mass index, CV disease in the family, diet and smoking. Quartiles of the CV risk score were calculated. Associations between the CV risk score and embryonic growth were assessed using square root transformed CRL in multivariable linear mixed model analyses.
MAIN RESULTS AND THE ROLE OF CHANCE
From the 111 included pregnancies, 696 3D US data sets were obtained of which 637 (91.5%) CRLs could be measured. In the total group, The CV risk score was inversely, but not significantly associated with embryonic growth (−0.03√mm; P = 0.291). Stratified by mode of conception, the CV risk score was inversely and significantly associated with embryonic growth (β = −0.04√mm; P = 0.025, adjusted for possible confounders) in the IVF/ICSI group. Compared with the first quartile, embryos in the upper quartile were 10.4% |
| doi_str_mv | 10.1093/humrep/dew060 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1790453737</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/humrep/dew060</oup_id><sourcerecordid>1790453737</sourcerecordid><originalsourceid>FETCH-LOGICAL-c365t-21c862d4d9a0defed650ba6374b6e65a826bd6d420e710f956d7b71ca691e15a3</originalsourceid><addsrcrecordid>eNqFkL1PwzAQxS0EoqUwsiKPLKF2PpxkRBWFSEgMFNbIsS-tS2IHO6Hqwt-OUQqM6IY7nd69e_ohdEnJDSV5NN8MrYVuLmFHGDlCUxozEoRRQo7RlIQsCyhldILOnNsS4seMnaJJmJIsSqJ8ij5XG8AdWCWMFtD1ymjc8h6s5g0W3EplPrgTQ8Mttsq94c6aWjWAla6bAfyNwz4C1xjayu6NVgKvrdn1G9xbvgXRG6u8RmlcvC7nxeK58Baw1lwLvz9HJzVvHFwc-gy9LO9Wi4fg8em-WNw-BiJiSR-EVGQslLHMOZFQg2QJqTiL0rhiwBKehaySTMYhgZSSOk-YTKuUCs5yCjTh0Qxdj74-_vsAri9b5QQ0DddgBlfSNCdxEqW-ZigYpcIa5yzUZWdVy-2-pKT8Rl6OyMsRuddfHayHqgX5q_5h_PfbDN0_Xl9Gn4--</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1790453737</pqid></control><display><type>article</type><title>The periconception maternal cardiovascular risk profile influences human embryonic growth trajectories in IVF/ICSI pregnancies</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Wijnands, K.P.J. ; van Uitert, E.M. ; Roeters van Lennep, J.E. ; Koning, A.H.J. ; Mulders, A.G.M.G.J. ; Laven, J.S.E. ; Steegers, E.A.P. ; Steegers-Theunissen, R.P.M.</creator><creatorcontrib>Wijnands, K.P.J. ; van Uitert, E.M. ; Roeters van Lennep, J.E. ; Koning, A.H.J. ; Mulders, A.G.M.G.J. ; Laven, J.S.E. ; Steegers, E.A.P. ; Steegers-Theunissen, R.P.M.</creatorcontrib><description>Abstract
STUDY QUESTION
Is the maternal cardiovascular (CV) risk profile associated with human embryonic growth trajectories and does the mode of conception affect this association?
SUMMARY ANSWER
This small study suggests that the maternal CV risk profile is inversely associated with first trimester embryonic growth trajectories in in vitro fertilization (IVF)/intra-cytoplasmic sperm injection (ICSI) pregnancies, but not in spontaneously conceived pregnancies.
WHAT IS KNOWN ALREADY
Maternal high-blood pressure and smoking affect placental function, accompanied by increased risk of fetal growth restriction and low-birthweight. Mothers who experience pregnancies complicated by fetal growth restriction are at increased risk of CV disease in later life.
STUDY DESIGN, SIZE, DURATION
In a prospective periconception birth cohort conducted in a tertiary hospital, 111 singleton ongoing pregnancies with reliable pregnancy dating, no pre-existing maternal disease and no malformed live borns were investigated.
PARTICIPANTS/MATERIALS, SETTINGS, METHODS
Spontaneously conceived pregnancies with a reliable first day of the last menstrual period and a regular menstrual cycle of 25–31 days only (n = 66) and IVF/ICSI pregnancies (n = 45) were included. Women underwent weekly three-dimensional ultrasound scans (3D US) from 6- to 13-week gestational age. To estimate embryonic growth, serial crown-rump length (CRL) measurements were performed using the V-Scope software in a BARCO I-Space. Maternal characteristics and CV risk factors were collected by self-administered questionnaires. The CV risk profile was created based on a score of risk factors, including maternal age, body-mass index, CV disease in the family, diet and smoking. Quartiles of the CV risk score were calculated. Associations between the CV risk score and embryonic growth were assessed using square root transformed CRL in multivariable linear mixed model analyses.
MAIN RESULTS AND THE ROLE OF CHANCE
From the 111 included pregnancies, 696 3D US data sets were obtained of which 637 (91.5%) CRLs could be measured. In the total group, The CV risk score was inversely, but not significantly associated with embryonic growth (−0.03√mm; P = 0.291). Stratified by mode of conception, the CV risk score was inversely and significantly associated with embryonic growth (β = −0.04√mm; P = 0.025, adjusted for possible confounders) in the IVF/ICSI group. Compared with the first quartile, embryos in the upper quartile were 10.4% smaller at 6+0 weeks (4.4 versus 4.9 mm) and 3.1% smaller at 12+0 weeks (56.5 versus 58.4 mm) of gestation. Although the CV risk score was slightly, but significantly, higher in women conceiving spontaneously compared with those undergoing IVF/ICSI treatment [CV risk score = 2.06 (SD: 1.23) and 1.60 (SD: 1.15), respectively], no association was established with embryonic growth in that particular group.
LIMITATIONS, REASONS FOR CAUTION
Participants included in the present cohort are women with a singleton ongoing pregnancy without any pre-existing disease and selected from a tertiary hospital. Hence, they represent a selected group of women. Larger and population-based periconception birth cohort studies are recommended to demonstrate external validity.
WIDER IMPLICATIONS OF THE FINDINGS
Differences in embryonic growth between pregnancies conceived spontaneously and after IVF/ICSI treatment in relation with CV risk factors substantiate the importance of more investigation into differences in sensitivity of endometrial, endothelial, placental and embryonic tissues.
STUDY FUNDING/COMPETING INTEREST(S)
Funded by the Department of Obstetrics and Gynaecology, Erasmus MC, University Medical Centre, Rotterdam, the Netherlands. The authors declare no conflict of interest.</description><identifier>ISSN: 0268-1161</identifier><identifier>EISSN: 1460-2350</identifier><identifier>DOI: 10.1093/humrep/dew060</identifier><identifier>PMID: 27083539</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Body Mass Index ; Cardiovascular Diseases - complications ; Crown-Rump Length ; Diet ; Embryonic Development ; Female ; Fertilization in Vitro ; Fetal Development ; Humans ; Hypertension - complications ; Maternal Age ; Prospective Studies ; Risk Assessment ; Risk Factors ; Smoking</subject><ispartof>Human reproduction (Oxford), 2016-06, Vol.31 (6), p.1173-1181</ispartof><rights>The Author 2016. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oup.com 2016</rights><rights>The Author 2016. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-21c862d4d9a0defed650ba6374b6e65a826bd6d420e710f956d7b71ca691e15a3</citedby><cites>FETCH-LOGICAL-c365t-21c862d4d9a0defed650ba6374b6e65a826bd6d420e710f956d7b71ca691e15a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1578,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27083539$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wijnands, K.P.J.</creatorcontrib><creatorcontrib>van Uitert, E.M.</creatorcontrib><creatorcontrib>Roeters van Lennep, J.E.</creatorcontrib><creatorcontrib>Koning, A.H.J.</creatorcontrib><creatorcontrib>Mulders, A.G.M.G.J.</creatorcontrib><creatorcontrib>Laven, J.S.E.</creatorcontrib><creatorcontrib>Steegers, E.A.P.</creatorcontrib><creatorcontrib>Steegers-Theunissen, R.P.M.</creatorcontrib><title>The periconception maternal cardiovascular risk profile influences human embryonic growth trajectories in IVF/ICSI pregnancies</title><title>Human reproduction (Oxford)</title><addtitle>Hum Reprod</addtitle><description>Abstract
STUDY QUESTION
Is the maternal cardiovascular (CV) risk profile associated with human embryonic growth trajectories and does the mode of conception affect this association?
SUMMARY ANSWER
This small study suggests that the maternal CV risk profile is inversely associated with first trimester embryonic growth trajectories in in vitro fertilization (IVF)/intra-cytoplasmic sperm injection (ICSI) pregnancies, but not in spontaneously conceived pregnancies.
WHAT IS KNOWN ALREADY
Maternal high-blood pressure and smoking affect placental function, accompanied by increased risk of fetal growth restriction and low-birthweight. Mothers who experience pregnancies complicated by fetal growth restriction are at increased risk of CV disease in later life.
STUDY DESIGN, SIZE, DURATION
In a prospective periconception birth cohort conducted in a tertiary hospital, 111 singleton ongoing pregnancies with reliable pregnancy dating, no pre-existing maternal disease and no malformed live borns were investigated.
PARTICIPANTS/MATERIALS, SETTINGS, METHODS
Spontaneously conceived pregnancies with a reliable first day of the last menstrual period and a regular menstrual cycle of 25–31 days only (n = 66) and IVF/ICSI pregnancies (n = 45) were included. Women underwent weekly three-dimensional ultrasound scans (3D US) from 6- to 13-week gestational age. To estimate embryonic growth, serial crown-rump length (CRL) measurements were performed using the V-Scope software in a BARCO I-Space. Maternal characteristics and CV risk factors were collected by self-administered questionnaires. The CV risk profile was created based on a score of risk factors, including maternal age, body-mass index, CV disease in the family, diet and smoking. Quartiles of the CV risk score were calculated. Associations between the CV risk score and embryonic growth were assessed using square root transformed CRL in multivariable linear mixed model analyses.
MAIN RESULTS AND THE ROLE OF CHANCE
From the 111 included pregnancies, 696 3D US data sets were obtained of which 637 (91.5%) CRLs could be measured. In the total group, The CV risk score was inversely, but not significantly associated with embryonic growth (−0.03√mm; P = 0.291). Stratified by mode of conception, the CV risk score was inversely and significantly associated with embryonic growth (β = −0.04√mm; P = 0.025, adjusted for possible confounders) in the IVF/ICSI group. Compared with the first quartile, embryos in the upper quartile were 10.4% smaller at 6+0 weeks (4.4 versus 4.9 mm) and 3.1% smaller at 12+0 weeks (56.5 versus 58.4 mm) of gestation. Although the CV risk score was slightly, but significantly, higher in women conceiving spontaneously compared with those undergoing IVF/ICSI treatment [CV risk score = 2.06 (SD: 1.23) and 1.60 (SD: 1.15), respectively], no association was established with embryonic growth in that particular group.
LIMITATIONS, REASONS FOR CAUTION
Participants included in the present cohort are women with a singleton ongoing pregnancy without any pre-existing disease and selected from a tertiary hospital. Hence, they represent a selected group of women. Larger and population-based periconception birth cohort studies are recommended to demonstrate external validity.
WIDER IMPLICATIONS OF THE FINDINGS
Differences in embryonic growth between pregnancies conceived spontaneously and after IVF/ICSI treatment in relation with CV risk factors substantiate the importance of more investigation into differences in sensitivity of endometrial, endothelial, placental and embryonic tissues.
STUDY FUNDING/COMPETING INTEREST(S)
Funded by the Department of Obstetrics and Gynaecology, Erasmus MC, University Medical Centre, Rotterdam, the Netherlands. The authors declare no conflict of interest.</description><subject>Body Mass Index</subject><subject>Cardiovascular Diseases - complications</subject><subject>Crown-Rump Length</subject><subject>Diet</subject><subject>Embryonic Development</subject><subject>Female</subject><subject>Fertilization in Vitro</subject><subject>Fetal Development</subject><subject>Humans</subject><subject>Hypertension - complications</subject><subject>Maternal Age</subject><subject>Prospective Studies</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Smoking</subject><issn>0268-1161</issn><issn>1460-2350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkL1PwzAQxS0EoqUwsiKPLKF2PpxkRBWFSEgMFNbIsS-tS2IHO6Hqwt-OUQqM6IY7nd69e_ohdEnJDSV5NN8MrYVuLmFHGDlCUxozEoRRQo7RlIQsCyhldILOnNsS4seMnaJJmJIsSqJ8ij5XG8AdWCWMFtD1ymjc8h6s5g0W3EplPrgTQ8Mttsq94c6aWjWAla6bAfyNwz4C1xjayu6NVgKvrdn1G9xbvgXRG6u8RmlcvC7nxeK58Baw1lwLvz9HJzVvHFwc-gy9LO9Wi4fg8em-WNw-BiJiSR-EVGQslLHMOZFQg2QJqTiL0rhiwBKehaySTMYhgZSSOk-YTKuUCs5yCjTh0Qxdj74-_vsAri9b5QQ0DddgBlfSNCdxEqW-ZigYpcIa5yzUZWdVy-2-pKT8Rl6OyMsRuddfHayHqgX5q_5h_PfbDN0_Xl9Gn4--</recordid><startdate>20160601</startdate><enddate>20160601</enddate><creator>Wijnands, K.P.J.</creator><creator>van Uitert, E.M.</creator><creator>Roeters van Lennep, J.E.</creator><creator>Koning, A.H.J.</creator><creator>Mulders, A.G.M.G.J.</creator><creator>Laven, J.S.E.</creator><creator>Steegers, E.A.P.</creator><creator>Steegers-Theunissen, R.P.M.</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160601</creationdate><title>The periconception maternal cardiovascular risk profile influences human embryonic growth trajectories in IVF/ICSI pregnancies</title><author>Wijnands, K.P.J. ; van Uitert, E.M. ; Roeters van Lennep, J.E. ; Koning, A.H.J. ; Mulders, A.G.M.G.J. ; Laven, J.S.E. ; Steegers, E.A.P. ; Steegers-Theunissen, R.P.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-21c862d4d9a0defed650ba6374b6e65a826bd6d420e710f956d7b71ca691e15a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Body Mass Index</topic><topic>Cardiovascular Diseases - complications</topic><topic>Crown-Rump Length</topic><topic>Diet</topic><topic>Embryonic Development</topic><topic>Female</topic><topic>Fertilization in Vitro</topic><topic>Fetal Development</topic><topic>Humans</topic><topic>Hypertension - complications</topic><topic>Maternal Age</topic><topic>Prospective Studies</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Smoking</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wijnands, K.P.J.</creatorcontrib><creatorcontrib>van Uitert, E.M.</creatorcontrib><creatorcontrib>Roeters van Lennep, J.E.</creatorcontrib><creatorcontrib>Koning, A.H.J.</creatorcontrib><creatorcontrib>Mulders, A.G.M.G.J.</creatorcontrib><creatorcontrib>Laven, J.S.E.</creatorcontrib><creatorcontrib>Steegers, E.A.P.</creatorcontrib><creatorcontrib>Steegers-Theunissen, R.P.M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Human reproduction (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wijnands, K.P.J.</au><au>van Uitert, E.M.</au><au>Roeters van Lennep, J.E.</au><au>Koning, A.H.J.</au><au>Mulders, A.G.M.G.J.</au><au>Laven, J.S.E.</au><au>Steegers, E.A.P.</au><au>Steegers-Theunissen, R.P.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The periconception maternal cardiovascular risk profile influences human embryonic growth trajectories in IVF/ICSI pregnancies</atitle><jtitle>Human reproduction (Oxford)</jtitle><addtitle>Hum Reprod</addtitle><date>2016-06-01</date><risdate>2016</risdate><volume>31</volume><issue>6</issue><spage>1173</spage><epage>1181</epage><pages>1173-1181</pages><issn>0268-1161</issn><eissn>1460-2350</eissn><abstract>Abstract
STUDY QUESTION
Is the maternal cardiovascular (CV) risk profile associated with human embryonic growth trajectories and does the mode of conception affect this association?
SUMMARY ANSWER
This small study suggests that the maternal CV risk profile is inversely associated with first trimester embryonic growth trajectories in in vitro fertilization (IVF)/intra-cytoplasmic sperm injection (ICSI) pregnancies, but not in spontaneously conceived pregnancies.
WHAT IS KNOWN ALREADY
Maternal high-blood pressure and smoking affect placental function, accompanied by increased risk of fetal growth restriction and low-birthweight. Mothers who experience pregnancies complicated by fetal growth restriction are at increased risk of CV disease in later life.
STUDY DESIGN, SIZE, DURATION
In a prospective periconception birth cohort conducted in a tertiary hospital, 111 singleton ongoing pregnancies with reliable pregnancy dating, no pre-existing maternal disease and no malformed live borns were investigated.
PARTICIPANTS/MATERIALS, SETTINGS, METHODS
Spontaneously conceived pregnancies with a reliable first day of the last menstrual period and a regular menstrual cycle of 25–31 days only (n = 66) and IVF/ICSI pregnancies (n = 45) were included. Women underwent weekly three-dimensional ultrasound scans (3D US) from 6- to 13-week gestational age. To estimate embryonic growth, serial crown-rump length (CRL) measurements were performed using the V-Scope software in a BARCO I-Space. Maternal characteristics and CV risk factors were collected by self-administered questionnaires. The CV risk profile was created based on a score of risk factors, including maternal age, body-mass index, CV disease in the family, diet and smoking. Quartiles of the CV risk score were calculated. Associations between the CV risk score and embryonic growth were assessed using square root transformed CRL in multivariable linear mixed model analyses.
MAIN RESULTS AND THE ROLE OF CHANCE
From the 111 included pregnancies, 696 3D US data sets were obtained of which 637 (91.5%) CRLs could be measured. In the total group, The CV risk score was inversely, but not significantly associated with embryonic growth (−0.03√mm; P = 0.291). Stratified by mode of conception, the CV risk score was inversely and significantly associated with embryonic growth (β = −0.04√mm; P = 0.025, adjusted for possible confounders) in the IVF/ICSI group. Compared with the first quartile, embryos in the upper quartile were 10.4% smaller at 6+0 weeks (4.4 versus 4.9 mm) and 3.1% smaller at 12+0 weeks (56.5 versus 58.4 mm) of gestation. Although the CV risk score was slightly, but significantly, higher in women conceiving spontaneously compared with those undergoing IVF/ICSI treatment [CV risk score = 2.06 (SD: 1.23) and 1.60 (SD: 1.15), respectively], no association was established with embryonic growth in that particular group.
LIMITATIONS, REASONS FOR CAUTION
Participants included in the present cohort are women with a singleton ongoing pregnancy without any pre-existing disease and selected from a tertiary hospital. Hence, they represent a selected group of women. Larger and population-based periconception birth cohort studies are recommended to demonstrate external validity.
WIDER IMPLICATIONS OF THE FINDINGS
Differences in embryonic growth between pregnancies conceived spontaneously and after IVF/ICSI treatment in relation with CV risk factors substantiate the importance of more investigation into differences in sensitivity of endometrial, endothelial, placental and embryonic tissues.
STUDY FUNDING/COMPETING INTEREST(S)
Funded by the Department of Obstetrics and Gynaecology, Erasmus MC, University Medical Centre, Rotterdam, the Netherlands. The authors declare no conflict of interest.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>27083539</pmid><doi>10.1093/humrep/dew060</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0268-1161 |
| ispartof | Human reproduction (Oxford), 2016-06, Vol.31 (6), p.1173-1181 |
| issn | 0268-1161 1460-2350 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1790453737 |
| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Body Mass Index Cardiovascular Diseases - complications Crown-Rump Length Diet Embryonic Development Female Fertilization in Vitro Fetal Development Humans Hypertension - complications Maternal Age Prospective Studies Risk Assessment Risk Factors Smoking |
| title | The periconception maternal cardiovascular risk profile influences human embryonic growth trajectories in IVF/ICSI pregnancies |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T14%3A21%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20periconception%20maternal%20cardiovascular%20risk%20profile%20influences%20human%20embryonic%20growth%20trajectories%20in%20IVF/ICSI%20pregnancies&rft.jtitle=Human%20reproduction%20(Oxford)&rft.au=Wijnands,%20K.P.J.&rft.date=2016-06-01&rft.volume=31&rft.issue=6&rft.spage=1173&rft.epage=1181&rft.pages=1173-1181&rft.issn=0268-1161&rft.eissn=1460-2350&rft_id=info:doi/10.1093/humrep/dew060&rft_dat=%3Cproquest_cross%3E1790453737%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1790453737&rft_id=info:pmid/27083539&rft_oup_id=10.1093/humrep/dew060&rfr_iscdi=true |