Genome-wide expression changes induced by HTLV-1 tax: evidence for MLK-3 mixed lineage kinase involvement in Tax-mediated NF-κB activation

The Tax protein of human T-lymphotropic virus type 1 (HTLV-1), an oncoprotein that transactivates viral and cellular genes, plays a key role in HTLV-1 replication and pathogenesis. We used cDNA microarrays to examine Tax-mediated transcriptional changes in the human Jurkat T-cell lines JPX-9 and JPX...

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