In utero complementation of a neural crest-derived melanocyte defect using cell directed gene transfer

This study describes an in utero approach for overexpressing genes in a cell‐type directed manner. It uses an avian leukosis retroviral expression system coupled with a transgenic mouse line expressing the viral receptor tv‐a from a tissue‐specific promoter (RCAS‐TVA system) (Federspiel et al., 1994...

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Veröffentlicht in:	Genesis (New York, N.Y. : 2000) N.Y. : 2000), 2001-06, Vol.30 (2), p.70-76
Hauptverfasser:	Dunn, Karen J., Incao, Arturo, Watkins-Chow, Dawn, Li, Yi, Pavan, William J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Avian leukosis virus Avian Leukosis Virus - genetics Avian Leukosis Virus - isolation & purification Avian Proteins Cell Differentiation complementation Embryo, Mammalian - cytology Gene Transfer Techniques Genetic Complementation Test melanocyte Melanocytes - cytology Melanocytes - metabolism Mice Mice, Transgenic neural crest Neural Crest - cytology Neural Crest - metabolism Proto-Oncogene Proteins - genetics RCAS RCAS gene Receptors, Virus - genetics Recombinant Proteins - genetics Recombinant Proteins - metabolism Signal Transduction Transfection tv-a gene tyrosinase Wnt Proteins Zebrafish Proteins
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