The role of cytochrome–P450 inhibitors in the prevention of hepatotoxicity after paracetamol overdose in rats

Despite the understanding that some cytochrome P450 isoforms are responsible for activation of paracetamol to the hepatotoxic metabolite, N–acetyl–p–benzoquinineimine (NAPQI), the use of enzyme inhibitors for prevention and/or treatment of paracetamol hepatotoxicity is still not well researched. Her...

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Veröffentlicht in:	Human & experimental toxicology 2004-01, Vol.23 (1), p.49-54
Hauptverfasser:	Walubo, A, Barr, S, Abraham, A M, Coetsee, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen - toxicity Analgesics Analgesics, Non-Narcotic - toxicity Animals Biological and medical sciences Caffeine Chemical and Drug Induced Liver Injury - enzymology Chemical and Drug Induced Liver Injury - pathology Chemical and Drug Induced Liver Injury - prevention & control Cytochrome Cytochrome P-450 Enzyme Inhibitors Drug dosages Drug Overdose Drug toxicity and drugs side effects treatment Enzyme Inhibitors - therapeutic use Enzymes Isoniazid - therapeutic use Ketoconazole - therapeutic use Liver Male Medical sciences Pharmacology. Drug treatments Prevention Rats Rats, Sprague-Dawley Toxicity: digestive system Toxicology
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