Translational Control Is Required for the Unfolded Protein Response and In Vivo Glucose Homeostasis

The accumulation of unfolded protein in the endoplasmic reticulum (ER) attenuates protein synthesis initiation through phosphorylation of the α subunit of eukaryotic translation initiation factor 2 (eIF2α) at Ser51. Subsequently, transcription of genes encoding adaptive functions including the gluco...

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Veröffentlicht in:	Molecular cell 2001-06, Vol.7 (6), p.1165-1176
Hauptverfasser:	Scheuner, Donalyn, Song, Benbo, McEwen, Edward, Liu, Chuan, Laybutt, Ross, Gillespie, Patrick, Saunders, Thom, Bonner-Weir, Susan, Kaufman, Randal J
Format:	Artikel
Sprache:	eng
Schlagworte:	Activating Transcription Factors Animals Animals, Newborn Blood Proteins - genetics Blood Proteins - metabolism Carrier Proteins - genetics Carrier Proteins - metabolism CCAAT-Enhancer-Binding Proteins - genetics CCAAT-Enhancer-Binding Proteins - metabolism Cell Survival - physiology DNA-Binding Proteins - chemistry DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Endoplasmic Reticulum - metabolism Gene Expression - physiology Germ-Line Mutation Gluconeogenesis - physiology glucose Glucose - metabolism Heat-Shock Proteins Homeostasis - physiology Homozygote Hypoglycemia - genetics Hypoglycemia - metabolism initiation factor eIF-2 Islets of Langerhans - cytology Islets of Langerhans - metabolism Mice Mice, Mutant Strains Molecular Chaperones - genetics Molecular Chaperones - metabolism Mutagenesis - physiology Phosphorylation Protein Biosynthesis - physiology Protein Folding RNA, Messenger - analysis Transcription Factor CHOP Transcription Factors - chemistry Transcription Factors - genetics Transcription Factors - metabolism Transcriptional Activation - physiology unfolded protein response
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