Predictive value of low tube voltage and dual-energy CT for successful shock wave lithotripsy: an in vitro study

This study investigates the capabilities of low tube voltage computed tomography (CT) and dual-energy CT (DECT) for predicting successful shock wave lithotripsy (SWL) of urinary stones in vitro. A total of 33 urinary calculi (six different chemical compositions; mean size 6 ± 3 mm) were scanned usin...

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Veröffentlicht in:Urolithiasis 2016-06, Vol.44 (3), p.271-276
Hauptverfasser: Largo, Remo, Stolzmann, Paul, Fankhauser, Christian D., Poyet, Cédric, Wolfsgruber, Pirmin, Sulser, Tullio, Alkadhi, Hatem, Winklhofer, Sebastian
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container_end_page 276
container_issue 3
container_start_page 271
container_title Urolithiasis
container_volume 44
creator Largo, Remo
Stolzmann, Paul
Fankhauser, Christian D.
Poyet, Cédric
Wolfsgruber, Pirmin
Sulser, Tullio
Alkadhi, Hatem
Winklhofer, Sebastian
description This study investigates the capabilities of low tube voltage computed tomography (CT) and dual-energy CT (DECT) for predicting successful shock wave lithotripsy (SWL) of urinary stones in vitro. A total of 33 urinary calculi (six different chemical compositions; mean size 6 ± 3 mm) were scanned using a dual-source CT machine with single- (120 kVp) and dual-energy settings (80/150, 100/150 Sn kVp) resulting in six different datasets. The attenuation (Hounsfield Units) of calculi was measured on single-energy CT images and the dual-energy indices (DEIs) were calculated from DECT acquisitions. Calculi underwent SWL and the number of shock waves for successful disintegration was recorded. The prediction of required shock waves regarding stone attenuation/DEI was calculated using regression analysis (adjusted for stone size and composition) and the correlation between CT attenuation/DEI and the number of shock waves was assessed for all datasets. The median number of shock waves for successful stone disintegration was 72 (interquartile range 30–361). CT attenuation/DEI of stones was a significant, independent predictor ( P  
doi_str_mv 10.1007/s00240-015-0824-y
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A total of 33 urinary calculi (six different chemical compositions; mean size 6 ± 3 mm) were scanned using a dual-source CT machine with single- (120 kVp) and dual-energy settings (80/150, 100/150 Sn kVp) resulting in six different datasets. The attenuation (Hounsfield Units) of calculi was measured on single-energy CT images and the dual-energy indices (DEIs) were calculated from DECT acquisitions. Calculi underwent SWL and the number of shock waves for successful disintegration was recorded. The prediction of required shock waves regarding stone attenuation/DEI was calculated using regression analysis (adjusted for stone size and composition) and the correlation between CT attenuation/DEI and the number of shock waves was assessed for all datasets. The median number of shock waves for successful stone disintegration was 72 (interquartile range 30–361). CT attenuation/DEI of stones was a significant, independent predictor ( P  &lt; 0.01) for the number of required shock waves with the best prediction at 80 kVp ( β estimate 0.576) ( P  &lt; 0.05). Correlation coefficients between attenuation/DEI and the number of required shock waves ranged between ρ  = 0.31 and 0.68 showing the best correlation at 80 kVp ( P  &lt; 0.001). The attenuation of urinary stones at low tube voltage CT is the best predictor for successful stone disintegration, being independent of stone composition and size. 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A total of 33 urinary calculi (six different chemical compositions; mean size 6 ± 3 mm) were scanned using a dual-source CT machine with single- (120 kVp) and dual-energy settings (80/150, 100/150 Sn kVp) resulting in six different datasets. The attenuation (Hounsfield Units) of calculi was measured on single-energy CT images and the dual-energy indices (DEIs) were calculated from DECT acquisitions. Calculi underwent SWL and the number of shock waves for successful disintegration was recorded. The prediction of required shock waves regarding stone attenuation/DEI was calculated using regression analysis (adjusted for stone size and composition) and the correlation between CT attenuation/DEI and the number of shock waves was assessed for all datasets. The median number of shock waves for successful stone disintegration was 72 (interquartile range 30–361). CT attenuation/DEI of stones was a significant, independent predictor ( P  &lt; 0.01) for the number of required shock waves with the best prediction at 80 kVp ( β estimate 0.576) ( P  &lt; 0.05). Correlation coefficients between attenuation/DEI and the number of required shock waves ranged between ρ  = 0.31 and 0.68 showing the best correlation at 80 kVp ( P  &lt; 0.001). The attenuation of urinary stones at low tube voltage CT is the best predictor for successful stone disintegration, being independent of stone composition and size. DECT shows no added value for predicting the success of SWL.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>26391614</pmid><doi>10.1007/s00240-015-0824-y</doi><tpages>6</tpages></addata></record>
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source MEDLINE; Springer Nature - Complete Springer Journals
subjects Electric Power Supplies
Humans
In Vitro Techniques
Lithotripsy
Medical Biochemistry
Medicine
Medicine & Public Health
Nephrology
Original Paper
Predictive Value of Tests
Tomography, X-Ray Computed - methods
Treatment Outcome
Urinary Calculi - diagnostic imaging
Urinary Calculi - therapy
Urology
title Predictive value of low tube voltage and dual-energy CT for successful shock wave lithotripsy: an in vitro study
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