Effect of Common Excipients on the Oral Drug Absorption of Biopharmaceutics Classification System Class 3 Drugs Cimetidine and Acyclovir

The objective was to assess the impact of larger than conventional amounts of 14 commonly used excipients on Biopharmaceutics Classification System (BCS) class 3 drug absorption in humans. Cimetidine and acyclovir were used as model class 3 drugs across three separate four-way crossover bioequivalen...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2016-02, Vol.105 (2), p.996-1005
Hauptverfasser:	Vaithianathan, Soundarya, Haidar, Sam H., Zhang, Xinyuan, Jiang, Wenlei, Avon, Christopher, Dowling, Thomas C., Shao, Changxing, Kane, Maureen, Hoag, Stephen W., Flasar, Mark H., Ting, Tricia Y., Polli, James E.
Format:	Artikel
Sprache:	eng
Schlagworte:	acyclovir Acyclovir - administration & dosage Acyclovir - metabolism Administration, Oral Adult bioequivalence Biopharmaceutics - classification Biopharmaceutics Classification System (BCS) cimetidine Cimetidine - administration & dosage Cimetidine - metabolism Cross-Over Studies Drug Interactions - physiology excipients Excipients - administration & dosage Excipients - metabolism Humans Intestinal Absorption - drug effects Intestinal Absorption - physiology oral absorption permeability
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