Characterization of Key Residues in the Subdomain Encoded by Exons 8 and 9 of Human Inducible Nitric Oxide Synthase: A Critical Role for Asp-280 in Substrate Binding and Subunit Interactions

Human inducible nitric oxide synthase (iNOS) is active as a dimer of two identical subunits. Each subunit has an amino-terminal oxygenase domain that binds the substrate L-Arg and the cofactors heme and tetrahydrobiopterin and a carboxyl-terminal reductase domain that binds FMN, FAD, and NADPH. We p...

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