Effect of Erythropoietin and Stem Cells on Traumatic Brain Injury
To investigate the healing effects of erythropoietin (EPO) and stem cells (SCs) in traumatic brain injury (TBI). Twenty-nine Wistar albino rats were used and separated into the following groups: control (C), EPO, SC, and SC+EPO. Group C received a TBI only, with no treatment. In the EPO group, 1000...
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| Veröffentlicht in: | World neurosurgery 2016-05, Vol.89, p.355-361 |
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| creator | Tunc Ata, Melek Turgut, Günfer Akbulut, Metin Kocyigit, Ali Karabulut, Aysun Senol, Hande Turgut, Sebahat |
| description | To investigate the healing effects of erythropoietin (EPO) and stem cells (SCs) in traumatic brain injury (TBI).
Twenty-nine Wistar albino rats were used and separated into the following groups: control (C), EPO, SC, and SC+EPO. Group C received a TBI only, with no treatment. In the EPO group, 1000 U/kg EPO was given intraperitoneally at 30 minutes after TBI. In SC group, immediately after formation of TBI, 3 × 10,000 CD34+ stem cells were injected into the affected area. In the SC+EPO group, half an hour after TBI and the injection of stem cells, 1000 U/kg EPO was injected. Before and after injury, trauma coordination performance was measured by the rotarod and inclined plane tests.
Seven weeks after trauma, rat brains were examined by radiology and histology. Rotarod performance test did not change remarkably, even after the injury. Compared with group C, the SC+EPO group was found to have significant differences in the inclined plane test results.
Separately given, SCs and EPO have a positive effect on TBI, and our findings suggest that their coadministration is even more powerful. |
| doi_str_mv | 10.1016/j.wneu.2016.01.040 |
| format | Article |
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Twenty-nine Wistar albino rats were used and separated into the following groups: control (C), EPO, SC, and SC+EPO. Group C received a TBI only, with no treatment. In the EPO group, 1000 U/kg EPO was given intraperitoneally at 30 minutes after TBI. In SC group, immediately after formation of TBI, 3 × 10,000 CD34+ stem cells were injected into the affected area. In the SC+EPO group, half an hour after TBI and the injection of stem cells, 1000 U/kg EPO was injected. Before and after injury, trauma coordination performance was measured by the rotarod and inclined plane tests.
Seven weeks after trauma, rat brains were examined by radiology and histology. Rotarod performance test did not change remarkably, even after the injury. Compared with group C, the SC+EPO group was found to have significant differences in the inclined plane test results.
Separately given, SCs and EPO have a positive effect on TBI, and our findings suggest that their coadministration is even more powerful.</description><identifier>ISSN: 1878-8750</identifier><identifier>EISSN: 1878-8769</identifier><identifier>DOI: 10.1016/j.wneu.2016.01.040</identifier><identifier>PMID: 26850972</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Antigens, CD34 - metabolism ; Brain - diagnostic imaging ; Brain - pathology ; Brain - physiopathology ; Brain Injuries, Traumatic - diagnostic imaging ; Brain Injuries, Traumatic - pathology ; Brain Injuries, Traumatic - physiopathology ; Brain Injuries, Traumatic - therapy ; Combined Modality Therapy ; Cord Blood Stem Cell Transplantation ; Disease Models, Animal ; Erythropoietin ; Erythropoietin - administration & dosage ; Female ; Humans ; Injections, Intraperitoneal ; Magnetic Resonance Imaging ; Male ; Neuroprotective Agents - administration & dosage ; Rats, Wistar ; Rotarod Performance Test ; Stem cell ; Traumatic brain injury ; Treatment Outcome</subject><ispartof>World neurosurgery, 2016-05, Vol.89, p.355-361</ispartof><rights>2016 Elsevier Inc.</rights><rights>Copyright © 2016 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-31b6f856080b3a761fa10e5a3afa7cf0bcc7faab4433cd2e541b425720803f1e3</citedby><cites>FETCH-LOGICAL-c356t-31b6f856080b3a761fa10e5a3afa7cf0bcc7faab4433cd2e541b425720803f1e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.wneu.2016.01.040$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26850972$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tunc Ata, Melek</creatorcontrib><creatorcontrib>Turgut, Günfer</creatorcontrib><creatorcontrib>Akbulut, Metin</creatorcontrib><creatorcontrib>Kocyigit, Ali</creatorcontrib><creatorcontrib>Karabulut, Aysun</creatorcontrib><creatorcontrib>Senol, Hande</creatorcontrib><creatorcontrib>Turgut, Sebahat</creatorcontrib><title>Effect of Erythropoietin and Stem Cells on Traumatic Brain Injury</title><title>World neurosurgery</title><addtitle>World Neurosurg</addtitle><description>To investigate the healing effects of erythropoietin (EPO) and stem cells (SCs) in traumatic brain injury (TBI).
Twenty-nine Wistar albino rats were used and separated into the following groups: control (C), EPO, SC, and SC+EPO. Group C received a TBI only, with no treatment. In the EPO group, 1000 U/kg EPO was given intraperitoneally at 30 minutes after TBI. In SC group, immediately after formation of TBI, 3 × 10,000 CD34+ stem cells were injected into the affected area. In the SC+EPO group, half an hour after TBI and the injection of stem cells, 1000 U/kg EPO was injected. Before and after injury, trauma coordination performance was measured by the rotarod and inclined plane tests.
Seven weeks after trauma, rat brains were examined by radiology and histology. Rotarod performance test did not change remarkably, even after the injury. Compared with group C, the SC+EPO group was found to have significant differences in the inclined plane test results.
Separately given, SCs and EPO have a positive effect on TBI, and our findings suggest that their coadministration is even more powerful.</description><subject>Animals</subject><subject>Antigens, CD34 - metabolism</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - pathology</subject><subject>Brain - physiopathology</subject><subject>Brain Injuries, Traumatic - diagnostic imaging</subject><subject>Brain Injuries, Traumatic - pathology</subject><subject>Brain Injuries, Traumatic - physiopathology</subject><subject>Brain Injuries, Traumatic - therapy</subject><subject>Combined Modality Therapy</subject><subject>Cord Blood Stem Cell Transplantation</subject><subject>Disease Models, Animal</subject><subject>Erythropoietin</subject><subject>Erythropoietin - administration & dosage</subject><subject>Female</subject><subject>Humans</subject><subject>Injections, Intraperitoneal</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Neuroprotective Agents - administration & dosage</subject><subject>Rats, Wistar</subject><subject>Rotarod Performance Test</subject><subject>Stem cell</subject><subject>Traumatic brain injury</subject><subject>Treatment Outcome</subject><issn>1878-8750</issn><issn>1878-8769</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kL1OwzAURi0EolXpCzAgjywJ_kliV2IpVYFKlRgos-U418JRkxQ7AfXtcdXSkbv4Duf7dH0QuqUkpYQWD3X608KQsrinhKYkIxdoTKWQiRTF7PK852SEpiHUJA6nmRT8Go1YIXMyE2yM5ktrwfS4s3jp9_2n73adg961WLcVfu-hwQvYbgPuWrzxemh07wx-8joSq7Ye_P4GXVm9DTA9vRP08bzcLF6T9dvLajFfJ4bnRZ9wWhZW5gWRpORaFNRqSiDXXFstjCWlMcJqXWYZ56ZikGe0zFguWAxwS4FP0P2xd-e7rwFCrxoXTLxNt9ANQVEhZyKXLGMRZUfU-C4ED1btvGu03ytK1MGeqtXBnjrYU4SqaC-G7k79Q9lAdY78uYrA4xGA-MtvB14F46A1UDkfFaqqc__1_wJ643-3</recordid><startdate>201605</startdate><enddate>201605</enddate><creator>Tunc Ata, Melek</creator><creator>Turgut, Günfer</creator><creator>Akbulut, Metin</creator><creator>Kocyigit, Ali</creator><creator>Karabulut, Aysun</creator><creator>Senol, Hande</creator><creator>Turgut, Sebahat</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201605</creationdate><title>Effect of Erythropoietin and Stem Cells on Traumatic Brain Injury</title><author>Tunc Ata, Melek ; Turgut, Günfer ; Akbulut, Metin ; Kocyigit, Ali ; Karabulut, Aysun ; Senol, Hande ; Turgut, Sebahat</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-31b6f856080b3a761fa10e5a3afa7cf0bcc7faab4433cd2e541b425720803f1e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Antigens, CD34 - metabolism</topic><topic>Brain - diagnostic imaging</topic><topic>Brain - pathology</topic><topic>Brain - physiopathology</topic><topic>Brain Injuries, Traumatic - diagnostic imaging</topic><topic>Brain Injuries, Traumatic - pathology</topic><topic>Brain Injuries, Traumatic - physiopathology</topic><topic>Brain Injuries, Traumatic - therapy</topic><topic>Combined Modality Therapy</topic><topic>Cord Blood Stem Cell Transplantation</topic><topic>Disease Models, Animal</topic><topic>Erythropoietin</topic><topic>Erythropoietin - administration & dosage</topic><topic>Female</topic><topic>Humans</topic><topic>Injections, Intraperitoneal</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Neuroprotective Agents - administration & dosage</topic><topic>Rats, Wistar</topic><topic>Rotarod Performance Test</topic><topic>Stem cell</topic><topic>Traumatic brain injury</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tunc Ata, Melek</creatorcontrib><creatorcontrib>Turgut, Günfer</creatorcontrib><creatorcontrib>Akbulut, Metin</creatorcontrib><creatorcontrib>Kocyigit, Ali</creatorcontrib><creatorcontrib>Karabulut, Aysun</creatorcontrib><creatorcontrib>Senol, Hande</creatorcontrib><creatorcontrib>Turgut, Sebahat</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>World neurosurgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tunc Ata, Melek</au><au>Turgut, Günfer</au><au>Akbulut, Metin</au><au>Kocyigit, Ali</au><au>Karabulut, Aysun</au><au>Senol, Hande</au><au>Turgut, Sebahat</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Erythropoietin and Stem Cells on Traumatic Brain Injury</atitle><jtitle>World neurosurgery</jtitle><addtitle>World Neurosurg</addtitle><date>2016-05</date><risdate>2016</risdate><volume>89</volume><spage>355</spage><epage>361</epage><pages>355-361</pages><issn>1878-8750</issn><eissn>1878-8769</eissn><abstract>To investigate the healing effects of erythropoietin (EPO) and stem cells (SCs) in traumatic brain injury (TBI).
Twenty-nine Wistar albino rats were used and separated into the following groups: control (C), EPO, SC, and SC+EPO. Group C received a TBI only, with no treatment. In the EPO group, 1000 U/kg EPO was given intraperitoneally at 30 minutes after TBI. In SC group, immediately after formation of TBI, 3 × 10,000 CD34+ stem cells were injected into the affected area. In the SC+EPO group, half an hour after TBI and the injection of stem cells, 1000 U/kg EPO was injected. Before and after injury, trauma coordination performance was measured by the rotarod and inclined plane tests.
Seven weeks after trauma, rat brains were examined by radiology and histology. Rotarod performance test did not change remarkably, even after the injury. Compared with group C, the SC+EPO group was found to have significant differences in the inclined plane test results.
Separately given, SCs and EPO have a positive effect on TBI, and our findings suggest that their coadministration is even more powerful.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>26850972</pmid><doi>10.1016/j.wneu.2016.01.040</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Antigens, CD34 - metabolism Brain - diagnostic imaging Brain - pathology Brain - physiopathology Brain Injuries, Traumatic - diagnostic imaging Brain Injuries, Traumatic - pathology Brain Injuries, Traumatic - physiopathology Brain Injuries, Traumatic - therapy Combined Modality Therapy Cord Blood Stem Cell Transplantation Disease Models, Animal Erythropoietin Erythropoietin - administration & dosage Female Humans Injections, Intraperitoneal Magnetic Resonance Imaging Male Neuroprotective Agents - administration & dosage Rats, Wistar Rotarod Performance Test Stem cell Traumatic brain injury Treatment Outcome |
| title | Effect of Erythropoietin and Stem Cells on Traumatic Brain Injury |
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