Identification and Characterization of K(+)-Dependent Na(+)-Ca(2+) Exchange Transport in Pigmented MEB4 Cells Mediated by NCKX4

The SLC24 gene family encodes K(+)-dependent Na(+)-Ca(2+) exchangers or NCKX proteins. The NCKX4 and NCKX5 isoforms have been shown to be important for pigmentation, and single nucleotide polymorphism (SNP) in both alleles of the SLC24a5 gene is the major genetic determinant for light skin in Caucas...

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Veröffentlicht in:	Biochemistry (Easton) 2016-05, Vol.55 (19), p.2704-2712
Hauptverfasser:	Szerencsei, Robert T, Ginger, Rebecca S, Green, Martin R, Schnetkamp, Paul P M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiporters - genetics Antiporters - metabolism Calcium - metabolism HEK293 Cells Humans Ion Transport - physiology Mice Potassium - metabolism Protein Isoforms - genetics Protein Isoforms - metabolism Sodium - metabolism
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