Carnosine and Homocarnosine Degradation Mechanisms by the Human Carnosinase Enzyme CN1: Insights from Multiscale Simulations

The endogenous dipeptide l-carnosine, and its derivative homocarnosine, prevent and reduce several pathologies like amytrophic lateral sclerosis (ALS), Alzheimer’s disease, and Parkinson’s disease. Their beneficial action is severely hampered because of the hydrolysis by carnosinase enzymes, in part...

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Veröffentlicht in:	Biochemistry (Easton) 2016-05, Vol.55 (19), p.2772-2784
Hauptverfasser:	Pavlin, Matic, Rossetti, Giulia, De Vivo, Marco, Carloni, Paolo
Format:	Artikel
Sprache:	eng
Schlagworte:	Carnosine - analogs & derivatives Carnosine - chemistry Carnosine - metabolism Catalytic Domain Dipeptidases - chemistry Dipeptidases - metabolism Humans Hydrogen Bonding Molecular Dynamics Simulation Zinc - chemistry Zinc - metabolism
Online-Zugang:	Volltext
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