Effects of Sho-saiko-to extract and its components, Baicalin, baicalein, glycyrrhizin and glycyrrhetic acid, on pharmacokinetic behavior of salicylamide in carbon tetrachloride intoxicated rats

To elucidate the effects of Sho-saiko-to extract and its components, baicalin, baicalein, glycyrrhizin and glycyrrhetic acid, against the effects of longer periods of acute hepatic injury induced by CCl 4, we measured serum ALT activity in male Wistar rats for five days after ip administration of CC...

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Veröffentlicht in:	Food and chemical toxicology 2004-05, Vol.42 (5), p.803-807
Hauptverfasser:	Taira, Zenei, Yabe, Kazunori, Hamaguchi, Yuka, Hirayama, Kensuke, Kishimoto, Makoto, Ishida, Shiro, Ueda, Yukari
Format:	Artikel
Sprache:	eng
Schlagworte:	acute toxicity alanine transaminase Alanine Transaminase - blood Animals antioxidant activity baicalein baicalin Biological and medical sciences Carbon tetrachloride Carbon Tetrachloride - toxicity chemical composition chemoprotection dosage dose response Drugs, Chinese Herbal - chemistry Drugs, Chinese Herbal - pharmacology Enzyme Induction - drug effects Flavanones Flavonoids - pharmacology glycyrrhetic acid Glycyrrhetinic Acid - pharmacology Glycyrrhiza Glycyrrhizic Acid - pharmacology glycyrrhizin Hepatic injury hepatoprotective effect hepatotoxicity herbal medicines Injections, Intraperitoneal Liver - drug effects Liver - enzymology Liver - pathology Liver - physiology liver function Liver Function Tests Liver Regeneration - drug effects Male Medical sciences medicinal plants nutrient-drug interactions oral administration Oriental traditional medicine oxidative stress Pharmacokinetics plant extracts Rats Rats, Wistar saikosaponin-D Salicylamide Salicylamides - pharmacokinetics salicylic acids Sho-saiko-to extract specialty crops Toxicology
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