Supplementation with l-arginine stabilizes plasma arginine and nitric oxide metabolites, suppresses elevated liver enzymes and peroxidation in sickle cell anaemia
The effect of l-arginine on liver function in SCD has received little or no attention. The effect of a chronic, oral, low-dose supplementation with l-arginine (1gm/day for 6 weeks) on some liver enzymes, lipid peroxidation and nitric oxide metabolites was studied in 20 normal (non-sickle cell anaemi...
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| Veröffentlicht in: | Pathophysiology (Amsterdam) 2016-06, Vol.23 (2), p.81-85 |
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| creator | Jaja, S.I. Ogungbemi, S.O. Kehinde, M.O. Anigbogu, C.N. |
| description | The effect of l-arginine on liver function in SCD has received little or no attention. The effect of a chronic, oral, low-dose supplementation with l-arginine (1gm/day for 6 weeks) on some liver enzymes, lipid peroxidation and nitric oxide metabolites was studied in 20 normal (non-sickle cell anaemia; NSCA) subjects and 20 sickle cell anaemia (SCA) subjects. Ten milliliters of blood was withdrawn from an ante-cubital vein for the estimation of plasma arginine concentration ([R]), alanine aminotransaminase (ALT), aspartate aminotransaminase (AST) and alkaline phosphatase (ALP), plasma total bilirubin concentration [TB], malondialdehyde concentration [MDA] and nitric oxide metabolites concentration [NOx]. Before supplementation, ALT, AST, ALP (p |
| doi_str_mv | 10.1016/j.pathophys.2016.04.004 |
| format | Article |
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The effect of a chronic, oral, low-dose supplementation with l-arginine (1gm/day for 6 weeks) on some liver enzymes, lipid peroxidation and nitric oxide metabolites was studied in 20 normal (non-sickle cell anaemia; NSCA) subjects and 20 sickle cell anaemia (SCA) subjects. Ten milliliters of blood was withdrawn from an ante-cubital vein for the estimation of plasma arginine concentration ([R]), alanine aminotransaminase (ALT), aspartate aminotransaminase (AST) and alkaline phosphatase (ALP), plasma total bilirubin concentration [TB], malondialdehyde concentration [MDA] and nitric oxide metabolites concentration [NOx]. Before supplementation, ALT, AST, ALP (p<0.05 respectively) and TB (p<0.001) were higher in SCA subjects than in NSCA subjects. [R] and [NOx] were higher in NSCA subjects (p<0.001 and p<0.05 respectively). Supplementation caused greater percent increases in [R], and [NOX] in SCA than in NSCA subjects (p<0.001 in each case). l-Arginine caused greater percent reductions in ALT and AST in SCA subjects but greater percent reduction in ALP in NSCA subjects (p<0.001 in each case). Changes in [MDA] and [TB] in the two groups were similar. Study shows that chronic, oral, low-dose supplementation with l-arginine improved liver function, oxidative stress, plasma arginine concentration and nitric oxide metabolites levels in NSCA and SCA subjects. Responses in SCA subjects to l-arginine were more sensitive than in NSCA subjects.]]></description><identifier>ISSN: 0928-4680</identifier><identifier>EISSN: 1873-149X</identifier><identifier>DOI: 10.1016/j.pathophys.2016.04.004</identifier><identifier>PMID: 27156372</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>l-Arginine ; Liver enzymes ; Malondialdehyde concentration ; Nitric oxide metabolites ; Plasma total bilirubin</subject><ispartof>Pathophysiology (Amsterdam), 2016-06, Vol.23 (2), p.81-85</ispartof><rights>2016 Elsevier B.V.</rights><rights>Copyright © 2016 Elsevier B.V. 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The effect of a chronic, oral, low-dose supplementation with l-arginine (1gm/day for 6 weeks) on some liver enzymes, lipid peroxidation and nitric oxide metabolites was studied in 20 normal (non-sickle cell anaemia; NSCA) subjects and 20 sickle cell anaemia (SCA) subjects. Ten milliliters of blood was withdrawn from an ante-cubital vein for the estimation of plasma arginine concentration ([R]), alanine aminotransaminase (ALT), aspartate aminotransaminase (AST) and alkaline phosphatase (ALP), plasma total bilirubin concentration [TB], malondialdehyde concentration [MDA] and nitric oxide metabolites concentration [NOx]. Before supplementation, ALT, AST, ALP (p<0.05 respectively) and TB (p<0.001) were higher in SCA subjects than in NSCA subjects. [R] and [NOx] were higher in NSCA subjects (p<0.001 and p<0.05 respectively). Supplementation caused greater percent increases in [R], and [NOX] in SCA than in NSCA subjects (p<0.001 in each case). l-Arginine caused greater percent reductions in ALT and AST in SCA subjects but greater percent reduction in ALP in NSCA subjects (p<0.001 in each case). Changes in [MDA] and [TB] in the two groups were similar. Study shows that chronic, oral, low-dose supplementation with l-arginine improved liver function, oxidative stress, plasma arginine concentration and nitric oxide metabolites levels in NSCA and SCA subjects. Responses in SCA subjects to l-arginine were more sensitive than in NSCA subjects.]]></description><subject>l-Arginine</subject><subject>Liver enzymes</subject><subject>Malondialdehyde concentration</subject><subject>Nitric oxide metabolites</subject><subject>Plasma total bilirubin</subject><issn>0928-4680</issn><issn>1873-149X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqFkcFu1DAQhi0EokvhFcBHDiTYiR0nx6oqFKkSB0DiZnntWXYWxwm2d2H7ODxpHW3ZK6eRZv5__hl9hLzhrOaMd-939Wzydpq3x1Q3pVEzUTMmnpAV71VbcTF8f0pWbGj6SnQ9uyAvUtoxxqVSzXNy0Sguu1Y1K_L3y36ePYwQssk4Bfob85b6ysQfGDAATdms0eM9JDp7k0ZDzyMTHA2YI1o6_UEHdIQinjxmSO9oKosjpFSM4OFgMjjq8QCRQrg_jqW9-GeIi_eUjYEmtD89UAvel7mBEc1L8mxjfIJXj_WSfPtw8_X6trr7_PHT9dVdZdtWigqYGKRqmIF-bSWXrLGia53cQNuwlinZbUxnOr7m0koYnAHVSClk5wbnhGDtJXl72jvH6dceUtYjpuUQE2DaJ81VP4hBqJ4XqTpJbZxSirDRc8TRxKPmTC-A9E6fAekFkGZCF0DF-foxZL8ewZ19_4gUwdVJAOXVA0LUySIECw4j2KzdhP8NeQDRFKrX</recordid><startdate>201606</startdate><enddate>201606</enddate><creator>Jaja, S.I.</creator><creator>Ogungbemi, S.O.</creator><creator>Kehinde, M.O.</creator><creator>Anigbogu, C.N.</creator><general>Elsevier B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201606</creationdate><title>Supplementation with l-arginine stabilizes plasma arginine and nitric oxide metabolites, suppresses elevated liver enzymes and peroxidation in sickle cell anaemia</title><author>Jaja, S.I. ; Ogungbemi, S.O. ; Kehinde, M.O. ; Anigbogu, C.N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3354-e0495720ae8bc51502c463d5fe32030756fa6a61b15c5e9dae7255456d9dd4403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>l-Arginine</topic><topic>Liver enzymes</topic><topic>Malondialdehyde concentration</topic><topic>Nitric oxide metabolites</topic><topic>Plasma total bilirubin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jaja, S.I.</creatorcontrib><creatorcontrib>Ogungbemi, S.O.</creatorcontrib><creatorcontrib>Kehinde, M.O.</creatorcontrib><creatorcontrib>Anigbogu, C.N.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pathophysiology (Amsterdam)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jaja, S.I.</au><au>Ogungbemi, S.O.</au><au>Kehinde, M.O.</au><au>Anigbogu, C.N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Supplementation with l-arginine stabilizes plasma arginine and nitric oxide metabolites, suppresses elevated liver enzymes and peroxidation in sickle cell anaemia</atitle><jtitle>Pathophysiology (Amsterdam)</jtitle><addtitle>Pathophysiology</addtitle><date>2016-06</date><risdate>2016</risdate><volume>23</volume><issue>2</issue><spage>81</spage><epage>85</epage><pages>81-85</pages><issn>0928-4680</issn><eissn>1873-149X</eissn><abstract><![CDATA[The effect of l-arginine on liver function in SCD has received little or no attention. The effect of a chronic, oral, low-dose supplementation with l-arginine (1gm/day for 6 weeks) on some liver enzymes, lipid peroxidation and nitric oxide metabolites was studied in 20 normal (non-sickle cell anaemia; NSCA) subjects and 20 sickle cell anaemia (SCA) subjects. Ten milliliters of blood was withdrawn from an ante-cubital vein for the estimation of plasma arginine concentration ([R]), alanine aminotransaminase (ALT), aspartate aminotransaminase (AST) and alkaline phosphatase (ALP), plasma total bilirubin concentration [TB], malondialdehyde concentration [MDA] and nitric oxide metabolites concentration [NOx]. Before supplementation, ALT, AST, ALP (p<0.05 respectively) and TB (p<0.001) were higher in SCA subjects than in NSCA subjects. [R] and [NOx] were higher in NSCA subjects (p<0.001 and p<0.05 respectively). Supplementation caused greater percent increases in [R], and [NOX] in SCA than in NSCA subjects (p<0.001 in each case). l-Arginine caused greater percent reductions in ALT and AST in SCA subjects but greater percent reduction in ALP in NSCA subjects (p<0.001 in each case). Changes in [MDA] and [TB] in the two groups were similar. Study shows that chronic, oral, low-dose supplementation with l-arginine improved liver function, oxidative stress, plasma arginine concentration and nitric oxide metabolites levels in NSCA and SCA subjects. Responses in SCA subjects to l-arginine were more sensitive than in NSCA subjects.]]></abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>27156372</pmid><doi>10.1016/j.pathophys.2016.04.004</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | l-Arginine Liver enzymes Malondialdehyde concentration Nitric oxide metabolites Plasma total bilirubin |
| title | Supplementation with l-arginine stabilizes plasma arginine and nitric oxide metabolites, suppresses elevated liver enzymes and peroxidation in sickle cell anaemia |
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