The Protective Role of HSP90 against 3-Hydroxykynurenine-Induced Neuronal Apoptosis

3-Hydroxykynurenine (3HK), an endogenous metabolite of tryptophan in the kynurenine pathway, is a potential neurotoxin in several neurodegenerative disorders. Stabilizing protein structure, heat shock proteins (HSPs) have diverse roles as molecular chaperones to mediate stress tolerance. In the pres...

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Veröffentlicht in:	Biochemical and biophysical research communications 2001-06, Vol.284 (2), p.261-267
Hauptverfasser:	Lee, Myoung-Woo, Park, Soon Cheol, Chae, Hee-Sun, Bach, Jae-Hyung, Lee, Hyun-Jung, Lee, Sang Hyung, Kang, Yong Koo, Kim, Kyung Yong, Lee, Won Bok, Kim, Sung Su
Format:	Artikel
Sprache:	eng
Schlagworte:	3-hydroxykynurenine apoptosis Apoptosis - drug effects Bisbenzimidazole Blotting, Western caspase Caspases - metabolism Cell Line Cell Survival - drug effects Cytoprotection - drug effects Dose-Response Relationship, Drug Enzyme Activation - drug effects heat shock protein 90 Heat-Shock Proteins Heat-Shock Response HSP27 Heat-Shock Proteins HSP70 Heat-Shock Proteins - genetics HSP70 Heat-Shock Proteins - metabolism HSP90 Heat-Shock Proteins - genetics HSP90 Heat-Shock Proteins - metabolism HSP90 Heat-Shock Proteins - pharmacology Humans Kynurenine - analogs & derivatives Kynurenine - antagonists & inhibitors Kynurenine - toxicity Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Neuroblastoma - metabolism Neuroblastoma - pathology Neurons - cytology Neurons - drug effects Neurons - metabolism Oligonucleotides, Antisense - pharmacology RNA, Messenger - antagonists & inhibitors RNA, Messenger - metabolism Temperature
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