Expression of NeuroD and TrkB in developing and aged mouse olfactory epithelium
To better understand the roles of NeuroD, a member of the basic helix-loop-helix transcription factor family, during the differentiation of olfactory receptor neurons, we studied the expression of NeuroD in developing and aging mouse olfactory epithelium (OE). During embryonic period, NeuroD express...
Gespeichert in:
| Veröffentlicht in: | Neuroreport 2001-06, Vol.12 (8), p.1615-1619 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1619 |
|---|---|
| container_issue | 8 |
| container_start_page | 1615 |
| container_title | Neuroreport |
| container_volume | 12 |
| creator | Nibu, Ken-ichi Kondo, Kenji Ohta, Yasushi Ishibashi, Toshio Rothstein, Jay L Kaga, Kimitaka |
| description | To better understand the roles of NeuroD, a member of the basic helix-loop-helix transcription factor family, during the differentiation of olfactory receptor neurons, we studied the expression of NeuroD in developing and aging mouse olfactory epithelium (OE). During embryonic period, NeuroD expression is confined in the basal compartment of OE. During neonatal period, NeuroD expression is detected in the middle compartment and in the basal compartment of OE. In the adult, the number of NeuroD expressing cells in the basal compartment significantly decreased, while the NeuroD- positive cells in the middle compartment was maintained throughout lifetime. This dual phase expression pattern of NeuroD suggests multiple roles of NeuroD in the neurogenesis of ORNs. |
| doi_str_mv | 10.1097/00001756-200106130-00021 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_17893690</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>17893690</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4831-daa5bcd782a2788c7661f92a5d28d3223d7d124a00fee3c7af1755159e4a3083</originalsourceid><addsrcrecordid>eNp1kUtP3DAQgK2Kqmyhf6HyBW5p_YztI6XQVkJw2QM3y9gTNsWJUzsp8O9x2S2cmMtIo28e_owQpuQLJUZ9JTWokm3DaiYt5aSpFUbfoRUVijdS6us9tCJGmkaYVu6jj6X8roghVH9A-5SKOoapFbo6e5gylNKnEacOX8KS03fsxoDX-e4b7kcc4C_ENPXj7XPZ3ULAQ1oK4BQ75-eUHzFM_byB2C_DIXrfuVjg0y4foPX52fr0Z3Nx9ePX6clF44XmtAnOyRsflGaOKa29alvaGeZkYDpwxnhQgTLhCOkAuFeuq8-VVBoQjhPND9DxduyU058FymyHvniI0Y1Qb7NUacNbQyqot6DPqZQMnZ1yP7j8aCmx_1za_y7ti0v77LK2ft7tWG4GCK-NO3kVONoBrngXu-xG35dXThAtlJKVE1vuPsUZcrmLyz1kuwEX54196y_5E1q2iug</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17893690</pqid></control><display><type>article</type><title>Expression of NeuroD and TrkB in developing and aged mouse olfactory epithelium</title><source>MEDLINE</source><source>Journals@Ovid Ovid Autoload</source><creator>Nibu, Ken-ichi ; Kondo, Kenji ; Ohta, Yasushi ; Ishibashi, Toshio ; Rothstein, Jay L ; Kaga, Kimitaka</creator><creatorcontrib>Nibu, Ken-ichi ; Kondo, Kenji ; Ohta, Yasushi ; Ishibashi, Toshio ; Rothstein, Jay L ; Kaga, Kimitaka</creatorcontrib><description>To better understand the roles of NeuroD, a member of the basic helix-loop-helix transcription factor family, during the differentiation of olfactory receptor neurons, we studied the expression of NeuroD in developing and aging mouse olfactory epithelium (OE). During embryonic period, NeuroD expression is confined in the basal compartment of OE. During neonatal period, NeuroD expression is detected in the middle compartment and in the basal compartment of OE. In the adult, the number of NeuroD expressing cells in the basal compartment significantly decreased, while the NeuroD- positive cells in the middle compartment was maintained throughout lifetime. This dual phase expression pattern of NeuroD suggests multiple roles of NeuroD in the neurogenesis of ORNs.</description><identifier>ISSN: 0959-4965</identifier><identifier>EISSN: 1473-558X</identifier><identifier>DOI: 10.1097/00001756-200106130-00021</identifier><identifier>PMID: 11409727</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Aging - metabolism ; Animals ; Basic Helix-Loop-Helix Transcription Factors ; Biological and medical sciences ; Bromodeoxyuridine - metabolism ; Embryo, Mammalian - metabolism ; Embryo, Mammalian - physiology ; Embryonic and Fetal Development ; Fundamental and applied biological sciences. Psychology ; Mice ; Mice, Inbred BALB C ; Nerve Tissue Proteins - metabolism ; neuroD protein ; Olfactory Mucosa - cytology ; Olfactory Mucosa - embryology ; Olfactory Mucosa - growth & development ; Olfactory Mucosa - metabolism ; Olfactory system and olfaction. Gustatory system and gustation ; Receptor, trkB - metabolism ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroreport, 2001-06, Vol.12 (8), p.1615-1619</ispartof><rights>2001 Lippincott Williams & Wilkins, Inc.</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4831-daa5bcd782a2788c7661f92a5d28d3223d7d124a00fee3c7af1755159e4a3083</citedby><cites>FETCH-LOGICAL-c4831-daa5bcd782a2788c7661f92a5d28d3223d7d124a00fee3c7af1755159e4a3083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14084775$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11409727$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nibu, Ken-ichi</creatorcontrib><creatorcontrib>Kondo, Kenji</creatorcontrib><creatorcontrib>Ohta, Yasushi</creatorcontrib><creatorcontrib>Ishibashi, Toshio</creatorcontrib><creatorcontrib>Rothstein, Jay L</creatorcontrib><creatorcontrib>Kaga, Kimitaka</creatorcontrib><title>Expression of NeuroD and TrkB in developing and aged mouse olfactory epithelium</title><title>Neuroreport</title><addtitle>Neuroreport</addtitle><description>To better understand the roles of NeuroD, a member of the basic helix-loop-helix transcription factor family, during the differentiation of olfactory receptor neurons, we studied the expression of NeuroD in developing and aging mouse olfactory epithelium (OE). During embryonic period, NeuroD expression is confined in the basal compartment of OE. During neonatal period, NeuroD expression is detected in the middle compartment and in the basal compartment of OE. In the adult, the number of NeuroD expressing cells in the basal compartment significantly decreased, while the NeuroD- positive cells in the middle compartment was maintained throughout lifetime. This dual phase expression pattern of NeuroD suggests multiple roles of NeuroD in the neurogenesis of ORNs.</description><subject>Aging - metabolism</subject><subject>Animals</subject><subject>Basic Helix-Loop-Helix Transcription Factors</subject><subject>Biological and medical sciences</subject><subject>Bromodeoxyuridine - metabolism</subject><subject>Embryo, Mammalian - metabolism</subject><subject>Embryo, Mammalian - physiology</subject><subject>Embryonic and Fetal Development</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Nerve Tissue Proteins - metabolism</subject><subject>neuroD protein</subject><subject>Olfactory Mucosa - cytology</subject><subject>Olfactory Mucosa - embryology</subject><subject>Olfactory Mucosa - growth & development</subject><subject>Olfactory Mucosa - metabolism</subject><subject>Olfactory system and olfaction. Gustatory system and gustation</subject><subject>Receptor, trkB - metabolism</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0959-4965</issn><issn>1473-558X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUtP3DAQgK2Kqmyhf6HyBW5p_YztI6XQVkJw2QM3y9gTNsWJUzsp8O9x2S2cmMtIo28e_owQpuQLJUZ9JTWokm3DaiYt5aSpFUbfoRUVijdS6us9tCJGmkaYVu6jj6X8roghVH9A-5SKOoapFbo6e5gylNKnEacOX8KS03fsxoDX-e4b7kcc4C_ENPXj7XPZ3ULAQ1oK4BQ75-eUHzFM_byB2C_DIXrfuVjg0y4foPX52fr0Z3Nx9ePX6clF44XmtAnOyRsflGaOKa29alvaGeZkYDpwxnhQgTLhCOkAuFeuq8-VVBoQjhPND9DxduyU058FymyHvniI0Y1Qb7NUacNbQyqot6DPqZQMnZ1yP7j8aCmx_1za_y7ti0v77LK2ft7tWG4GCK-NO3kVONoBrngXu-xG35dXThAtlJKVE1vuPsUZcrmLyz1kuwEX54196y_5E1q2iug</recordid><startdate>20010613</startdate><enddate>20010613</enddate><creator>Nibu, Ken-ichi</creator><creator>Kondo, Kenji</creator><creator>Ohta, Yasushi</creator><creator>Ishibashi, Toshio</creator><creator>Rothstein, Jay L</creator><creator>Kaga, Kimitaka</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams and Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20010613</creationdate><title>Expression of NeuroD and TrkB in developing and aged mouse olfactory epithelium</title><author>Nibu, Ken-ichi ; Kondo, Kenji ; Ohta, Yasushi ; Ishibashi, Toshio ; Rothstein, Jay L ; Kaga, Kimitaka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4831-daa5bcd782a2788c7661f92a5d28d3223d7d124a00fee3c7af1755159e4a3083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Aging - metabolism</topic><topic>Animals</topic><topic>Basic Helix-Loop-Helix Transcription Factors</topic><topic>Biological and medical sciences</topic><topic>Bromodeoxyuridine - metabolism</topic><topic>Embryo, Mammalian - metabolism</topic><topic>Embryo, Mammalian - physiology</topic><topic>Embryonic and Fetal Development</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Nerve Tissue Proteins - metabolism</topic><topic>neuroD protein</topic><topic>Olfactory Mucosa - cytology</topic><topic>Olfactory Mucosa - embryology</topic><topic>Olfactory Mucosa - growth & development</topic><topic>Olfactory Mucosa - metabolism</topic><topic>Olfactory system and olfaction. Gustatory system and gustation</topic><topic>Receptor, trkB - metabolism</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nibu, Ken-ichi</creatorcontrib><creatorcontrib>Kondo, Kenji</creatorcontrib><creatorcontrib>Ohta, Yasushi</creatorcontrib><creatorcontrib>Ishibashi, Toshio</creatorcontrib><creatorcontrib>Rothstein, Jay L</creatorcontrib><creatorcontrib>Kaga, Kimitaka</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Neuroreport</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nibu, Ken-ichi</au><au>Kondo, Kenji</au><au>Ohta, Yasushi</au><au>Ishibashi, Toshio</au><au>Rothstein, Jay L</au><au>Kaga, Kimitaka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of NeuroD and TrkB in developing and aged mouse olfactory epithelium</atitle><jtitle>Neuroreport</jtitle><addtitle>Neuroreport</addtitle><date>2001-06-13</date><risdate>2001</risdate><volume>12</volume><issue>8</issue><spage>1615</spage><epage>1619</epage><pages>1615-1619</pages><issn>0959-4965</issn><eissn>1473-558X</eissn><abstract>To better understand the roles of NeuroD, a member of the basic helix-loop-helix transcription factor family, during the differentiation of olfactory receptor neurons, we studied the expression of NeuroD in developing and aging mouse olfactory epithelium (OE). During embryonic period, NeuroD expression is confined in the basal compartment of OE. During neonatal period, NeuroD expression is detected in the middle compartment and in the basal compartment of OE. In the adult, the number of NeuroD expressing cells in the basal compartment significantly decreased, while the NeuroD- positive cells in the middle compartment was maintained throughout lifetime. This dual phase expression pattern of NeuroD suggests multiple roles of NeuroD in the neurogenesis of ORNs.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>11409727</pmid><doi>10.1097/00001756-200106130-00021</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0959-4965 |
| ispartof | Neuroreport, 2001-06, Vol.12 (8), p.1615-1619 |
| issn | 0959-4965 1473-558X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_17893690 |
| source | MEDLINE; Journals@Ovid Ovid Autoload |
| subjects | Aging - metabolism Animals Basic Helix-Loop-Helix Transcription Factors Biological and medical sciences Bromodeoxyuridine - metabolism Embryo, Mammalian - metabolism Embryo, Mammalian - physiology Embryonic and Fetal Development Fundamental and applied biological sciences. Psychology Mice Mice, Inbred BALB C Nerve Tissue Proteins - metabolism neuroD protein Olfactory Mucosa - cytology Olfactory Mucosa - embryology Olfactory Mucosa - growth & development Olfactory Mucosa - metabolism Olfactory system and olfaction. Gustatory system and gustation Receptor, trkB - metabolism Vertebrates: nervous system and sense organs |
| title | Expression of NeuroD and TrkB in developing and aged mouse olfactory epithelium |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T05%3A02%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Expression%20of%20NeuroD%20and%20TrkB%20in%20developing%20and%20aged%20mouse%20olfactory%20epithelium&rft.jtitle=Neuroreport&rft.au=Nibu,%20Ken-ichi&rft.date=2001-06-13&rft.volume=12&rft.issue=8&rft.spage=1615&rft.epage=1619&rft.pages=1615-1619&rft.issn=0959-4965&rft.eissn=1473-558X&rft_id=info:doi/10.1097/00001756-200106130-00021&rft_dat=%3Cproquest_cross%3E17893690%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17893690&rft_id=info:pmid/11409727&rfr_iscdi=true |