Targeted Disruption of Cadherin‐11 Leads to a Reduction in Bone Density in Calvaria and Long Bone Metaphyses

The migration and adhesion of osteoblasts requires several classical cadherins. Cadherin‐11, one of the classical cadherins, was expressed in mouse osteoblasts in skull bone and femur, revealed by immunohistochemistry. To elucidate the function of cadherin‐11 in osteoblastogenesis, cadherin‐11 null...

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Veröffentlicht in:	Journal of bone and mineral research 2001-07, Vol.16 (7), p.1265-1271
Hauptverfasser:	Kawaguchi, Jitsutaro, Azuma, Yoshiaki, Hoshi, Kazuto, Kii, Isao, Takeshita, Sunao, Ohta, Tomohiro, Ozawa, Hidehiro, Takeichi, Masatoshi, Chisaka, Osamu, Kudo, Akira
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Biological and medical sciences Blotting, Western bone density Bone Density - genetics cadherin Cadherins - genetics Cadherins - metabolism calcification Cell Differentiation - genetics Cells, Cultured Female Femur - abnormalities Femur - physiology Fundamental and applied biological sciences. Psychology Gene Deletion Immunohistochemistry Male Mice Mice, Knockout Mutagenesis, Site-Directed - genetics null mutant osteoblast Osteoblasts - cytology Osteoblasts - metabolism Osteogenesis - genetics Phenotype Polymerase Chain Reaction Skeleton and joints Skull - abnormalities Skull - physiology Tibia - abnormalities Tibia - physiology Tomography Scanners, X-Ray Computed Vertebrates: osteoarticular system, musculoskeletal system
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