Use of hydrostatic pressure for modulation of protein chemical modification and enzymatic selectivity

Using hydrostatic pressure to induce protein conformational changes can be a powerful tool for altering the availability of protein reactive sites and for changing the selectivity of enzymatic reactions. Using a pressure apparatus, it has been demonstrated that hydrostatic pressure can be used to mo...

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Veröffentlicht in:	Organic & biomolecular chemistry 2016-05, Vol.14 (19), p.4448-4455
Hauptverfasser:	Makarov, Alexey A, Helmy, Roy, Joyce, Leo, Reibarkh, Mikhail, Maust, Mathew, Ren, Sumei, Mergelsberg, Ingrid, Welch, Christopher J
Format:	Artikel
Sprache:	eng
Schlagworte:	Amines - chemistry Animals Enzymes - chemistry Enzymes - metabolism Hydrostatic Pressure Protein Binding Proteins - chemistry Proteins - metabolism Solubility Substrate Specificity Water - chemistry
Online-Zugang:	Volltext
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