The predictive role of ADC values in prostate cancer patients treated with carbon-ion radiotherapy: initial clinical experience at Shanghai Proton and Heavy Ion Center (SPHIC)
Objective The aim of our study was to investigate the predictive role of apparent diffusion coefficient (ADC) values in evaluating for therapeutic changes from carbon-ion radiotherapy (CIRT) in prostate cancer patients. Materials and methods Thirty-one patients with prostate cancer treated with CIRT...
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| Veröffentlicht in: | Journal of cancer research and clinical oncology 2016-06, Vol.142 (6), p.1361-1367 |
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| creator | Qi, Wei-Xiang Zhang, Qing Li, Ping Zhang, Xiao-Meng Zhang, Guang-Yuan Wu, Bin Lu, Jiade J. Jiang, Guo-Liang Fu, Shen |
| description | Objective
The aim of our study was to investigate the predictive role of apparent diffusion coefficient (ADC) values in evaluating for therapeutic changes from carbon-ion radiotherapy (CIRT) in prostate cancer patients.
Materials and methods
Thirty-one patients with prostate cancer treated with CIRT were enrolled in this retrospective study. Diffusion-weighted imaging (DWI) at 3-T was performed before and after CIRT. Before and after treatment, ADC values were measured in the tumors and in the benign tissues of the prostate, and serum prostate-specific antigen (PSA) levels were also assessed. We divided the patients into two groups: PSA response (PSA declines ≥50 %) and non-PSA response group (PSA declines |
| doi_str_mv | 10.1007/s00432-016-2142-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1789038774</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4054242451</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-219ba2f89766530d64a9e914efd8f4d78943d68ea25ddbe481570a82cd2494a43</originalsourceid><addsrcrecordid>eNp1kU1v1DAQhi0EokvhB3BBlriUQ8BfiRNuVfjYlSpRqeUcee1J4yrrBNu7sL-Kv8hEWxBC4uTxzDPv2PMS8pKzt5wx_S4xpqQoGK8KwZUo5COy4kuGS1k-JivGNS9Kwasz8iyle4b3Uoun5ExoxmrGyhX5eTsAnSM4b7M_AI3TCHTq6eWHlh7MuIdEfUBgStlkoNYEC5HOJnsIOdEcAdOOfvd5wGLcTqHwU6DROD_lAaKZj-9RwWdvRmpHjCwG8GOGiAoWqMn0ZjDhbjCeXscpY7MJjq7BHI50g7cWB-HIi5vr9aZ985w86c2Y4MXDeU6-fvp4266Lqy-fN-3lVWGlFhnX0WyN6OtGV1UpmauUaaDhCnpX98rpulHSVTUYUTq3BVXzUjNTC-uEapRR8pxcnHTx699wC7nb-WRhHE2AaZ86jhJM1lov6Ot_0PtpHwO-bqFq1TDNGqT4ibK4yxSh7-bodyYeO866xc3u5GaHbnaLm53EnlcPyvvtDtyfjt_2ISBOQMJSuIP41-j_qv4CZ1qq3w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1788490709</pqid></control><display><type>article</type><title>The predictive role of ADC values in prostate cancer patients treated with carbon-ion radiotherapy: initial clinical experience at Shanghai Proton and Heavy Ion Center (SPHIC)</title><source>MEDLINE</source><source>Springer Online Journals Complete</source><creator>Qi, Wei-Xiang ; Zhang, Qing ; Li, Ping ; Zhang, Xiao-Meng ; Zhang, Guang-Yuan ; Wu, Bin ; Lu, Jiade J. ; Jiang, Guo-Liang ; Fu, Shen</creator><creatorcontrib>Qi, Wei-Xiang ; Zhang, Qing ; Li, Ping ; Zhang, Xiao-Meng ; Zhang, Guang-Yuan ; Wu, Bin ; Lu, Jiade J. ; Jiang, Guo-Liang ; Fu, Shen</creatorcontrib><description>Objective
The aim of our study was to investigate the predictive role of apparent diffusion coefficient (ADC) values in evaluating for therapeutic changes from carbon-ion radiotherapy (CIRT) in prostate cancer patients.
Materials and methods
Thirty-one patients with prostate cancer treated with CIRT were enrolled in this retrospective study. Diffusion-weighted imaging (DWI) at 3-T was performed before and after CIRT. Before and after treatment, ADC values were measured in the tumors and in the benign tissues of the prostate, and serum prostate-specific antigen (PSA) levels were also assessed. We divided the patients into two groups: PSA response (PSA declines ≥50 %) and non-PSA response group (PSA declines <50 %).
Results
After CIRT treatment, the mean ADC value of the tumors (1.23 × 10
−3
mm
2
/s) was significantly increased as compared with the pretreatment value (1.07 × 10
−3
mm
2
/s) (
p
< 0.001), whereas the ADC values of the benign tissues after treatment did not significantly increase compared with the pretreatment values (
p
= 0.235). The mean PSA level was significantly reduced from 2.027 ng/mL before treatment to 0.822 ng/mL, respectively, after treatment (
p
= 0.0063). The mean of ADC changes in PSA response group before and after CIRT was significantly higher than that in non-PSA response group (∆ADC value: 0.217 vs 0.097 × 10
−3
mm
2
/s,
p
= 0.0229), and the rate of patients with PSA response was higher in the high ∆ADC group (∆ADC ≥ 0.10) than in the low ∆ADC group (∆ADC < 0.10) (72.7 and 33.3 %, respectively), but marginally significant (
p
= 0.056). Additionally, the baseline tumor ADC values revealed a negative correlation with changes in PSA levels after treatment (correlation coefficient,
ρ
= −0.524;
p
= 0.0025).
Conclusion
Our preliminary results suggest that ADC vales measurement may be a useful imaging biomarker for prediction and early assessment of therapeutic response of prostate cancer to CIRT.</description><identifier>ISSN: 0171-5216</identifier><identifier>EISSN: 1432-1335</identifier><identifier>DOI: 10.1007/s00432-016-2142-3</identifier><identifier>PMID: 27008005</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Aged ; Aged, 80 and over ; Cancer Research ; Carbon ; China ; Hematology ; Humans ; Internal Medicine ; Ions ; Magnetic Resonance Imaging ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Oncology ; Original Article – Clinical Oncology ; Prostate cancer ; Prostatic Neoplasms - radiotherapy ; Protons ; Radiation therapy ; Radiotherapy - methods ; Retrospective Studies</subject><ispartof>Journal of cancer research and clinical oncology, 2016-06, Vol.142 (6), p.1361-1367</ispartof><rights>Springer-Verlag Berlin Heidelberg 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-219ba2f89766530d64a9e914efd8f4d78943d68ea25ddbe481570a82cd2494a43</citedby><cites>FETCH-LOGICAL-c372t-219ba2f89766530d64a9e914efd8f4d78943d68ea25ddbe481570a82cd2494a43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00432-016-2142-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00432-016-2142-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27008005$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Qi, Wei-Xiang</creatorcontrib><creatorcontrib>Zhang, Qing</creatorcontrib><creatorcontrib>Li, Ping</creatorcontrib><creatorcontrib>Zhang, Xiao-Meng</creatorcontrib><creatorcontrib>Zhang, Guang-Yuan</creatorcontrib><creatorcontrib>Wu, Bin</creatorcontrib><creatorcontrib>Lu, Jiade J.</creatorcontrib><creatorcontrib>Jiang, Guo-Liang</creatorcontrib><creatorcontrib>Fu, Shen</creatorcontrib><title>The predictive role of ADC values in prostate cancer patients treated with carbon-ion radiotherapy: initial clinical experience at Shanghai Proton and Heavy Ion Center (SPHIC)</title><title>Journal of cancer research and clinical oncology</title><addtitle>J Cancer Res Clin Oncol</addtitle><addtitle>J Cancer Res Clin Oncol</addtitle><description>Objective
The aim of our study was to investigate the predictive role of apparent diffusion coefficient (ADC) values in evaluating for therapeutic changes from carbon-ion radiotherapy (CIRT) in prostate cancer patients.
Materials and methods
Thirty-one patients with prostate cancer treated with CIRT were enrolled in this retrospective study. Diffusion-weighted imaging (DWI) at 3-T was performed before and after CIRT. Before and after treatment, ADC values were measured in the tumors and in the benign tissues of the prostate, and serum prostate-specific antigen (PSA) levels were also assessed. We divided the patients into two groups: PSA response (PSA declines ≥50 %) and non-PSA response group (PSA declines <50 %).
Results
After CIRT treatment, the mean ADC value of the tumors (1.23 × 10
−3
mm
2
/s) was significantly increased as compared with the pretreatment value (1.07 × 10
−3
mm
2
/s) (
p
< 0.001), whereas the ADC values of the benign tissues after treatment did not significantly increase compared with the pretreatment values (
p
= 0.235). The mean PSA level was significantly reduced from 2.027 ng/mL before treatment to 0.822 ng/mL, respectively, after treatment (
p
= 0.0063). The mean of ADC changes in PSA response group before and after CIRT was significantly higher than that in non-PSA response group (∆ADC value: 0.217 vs 0.097 × 10
−3
mm
2
/s,
p
= 0.0229), and the rate of patients with PSA response was higher in the high ∆ADC group (∆ADC ≥ 0.10) than in the low ∆ADC group (∆ADC < 0.10) (72.7 and 33.3 %, respectively), but marginally significant (
p
= 0.056). Additionally, the baseline tumor ADC values revealed a negative correlation with changes in PSA levels after treatment (correlation coefficient,
ρ
= −0.524;
p
= 0.0025).
Conclusion
Our preliminary results suggest that ADC vales measurement may be a useful imaging biomarker for prediction and early assessment of therapeutic response of prostate cancer to CIRT.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cancer Research</subject><subject>Carbon</subject><subject>China</subject><subject>Hematology</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Ions</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Oncology</subject><subject>Original Article – Clinical Oncology</subject><subject>Prostate cancer</subject><subject>Prostatic Neoplasms - radiotherapy</subject><subject>Protons</subject><subject>Radiation therapy</subject><subject>Radiotherapy - methods</subject><subject>Retrospective Studies</subject><issn>0171-5216</issn><issn>1432-1335</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kU1v1DAQhi0EokvhB3BBlriUQ8BfiRNuVfjYlSpRqeUcee1J4yrrBNu7sL-Kv8hEWxBC4uTxzDPv2PMS8pKzt5wx_S4xpqQoGK8KwZUo5COy4kuGS1k-JivGNS9Kwasz8iyle4b3Uoun5ExoxmrGyhX5eTsAnSM4b7M_AI3TCHTq6eWHlh7MuIdEfUBgStlkoNYEC5HOJnsIOdEcAdOOfvd5wGLcTqHwU6DROD_lAaKZj-9RwWdvRmpHjCwG8GOGiAoWqMn0ZjDhbjCeXscpY7MJjq7BHI50g7cWB-HIi5vr9aZ985w86c2Y4MXDeU6-fvp4266Lqy-fN-3lVWGlFhnX0WyN6OtGV1UpmauUaaDhCnpX98rpulHSVTUYUTq3BVXzUjNTC-uEapRR8pxcnHTx699wC7nb-WRhHE2AaZ86jhJM1lov6Ot_0PtpHwO-bqFq1TDNGqT4ibK4yxSh7-bodyYeO866xc3u5GaHbnaLm53EnlcPyvvtDtyfjt_2ISBOQMJSuIP41-j_qv4CZ1qq3w</recordid><startdate>20160601</startdate><enddate>20160601</enddate><creator>Qi, Wei-Xiang</creator><creator>Zhang, Qing</creator><creator>Li, Ping</creator><creator>Zhang, Xiao-Meng</creator><creator>Zhang, Guang-Yuan</creator><creator>Wu, Bin</creator><creator>Lu, Jiade J.</creator><creator>Jiang, Guo-Liang</creator><creator>Fu, Shen</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20160601</creationdate><title>The predictive role of ADC values in prostate cancer patients treated with carbon-ion radiotherapy: initial clinical experience at Shanghai Proton and Heavy Ion Center (SPHIC)</title><author>Qi, Wei-Xiang ; Zhang, Qing ; Li, Ping ; Zhang, Xiao-Meng ; Zhang, Guang-Yuan ; Wu, Bin ; Lu, Jiade J. ; Jiang, Guo-Liang ; Fu, Shen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-219ba2f89766530d64a9e914efd8f4d78943d68ea25ddbe481570a82cd2494a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cancer Research</topic><topic>Carbon</topic><topic>China</topic><topic>Hematology</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Ions</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Oncology</topic><topic>Original Article – Clinical Oncology</topic><topic>Prostate cancer</topic><topic>Prostatic Neoplasms - radiotherapy</topic><topic>Protons</topic><topic>Radiation therapy</topic><topic>Radiotherapy - methods</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Qi, Wei-Xiang</creatorcontrib><creatorcontrib>Zhang, Qing</creatorcontrib><creatorcontrib>Li, Ping</creatorcontrib><creatorcontrib>Zhang, Xiao-Meng</creatorcontrib><creatorcontrib>Zhang, Guang-Yuan</creatorcontrib><creatorcontrib>Wu, Bin</creatorcontrib><creatorcontrib>Lu, Jiade J.</creatorcontrib><creatorcontrib>Jiang, Guo-Liang</creatorcontrib><creatorcontrib>Fu, Shen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cancer research and clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Qi, Wei-Xiang</au><au>Zhang, Qing</au><au>Li, Ping</au><au>Zhang, Xiao-Meng</au><au>Zhang, Guang-Yuan</au><au>Wu, Bin</au><au>Lu, Jiade J.</au><au>Jiang, Guo-Liang</au><au>Fu, Shen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The predictive role of ADC values in prostate cancer patients treated with carbon-ion radiotherapy: initial clinical experience at Shanghai Proton and Heavy Ion Center (SPHIC)</atitle><jtitle>Journal of cancer research and clinical oncology</jtitle><stitle>J Cancer Res Clin Oncol</stitle><addtitle>J Cancer Res Clin Oncol</addtitle><date>2016-06-01</date><risdate>2016</risdate><volume>142</volume><issue>6</issue><spage>1361</spage><epage>1367</epage><pages>1361-1367</pages><issn>0171-5216</issn><eissn>1432-1335</eissn><abstract>Objective
The aim of our study was to investigate the predictive role of apparent diffusion coefficient (ADC) values in evaluating for therapeutic changes from carbon-ion radiotherapy (CIRT) in prostate cancer patients.
Materials and methods
Thirty-one patients with prostate cancer treated with CIRT were enrolled in this retrospective study. Diffusion-weighted imaging (DWI) at 3-T was performed before and after CIRT. Before and after treatment, ADC values were measured in the tumors and in the benign tissues of the prostate, and serum prostate-specific antigen (PSA) levels were also assessed. We divided the patients into two groups: PSA response (PSA declines ≥50 %) and non-PSA response group (PSA declines <50 %).
Results
After CIRT treatment, the mean ADC value of the tumors (1.23 × 10
−3
mm
2
/s) was significantly increased as compared with the pretreatment value (1.07 × 10
−3
mm
2
/s) (
p
< 0.001), whereas the ADC values of the benign tissues after treatment did not significantly increase compared with the pretreatment values (
p
= 0.235). The mean PSA level was significantly reduced from 2.027 ng/mL before treatment to 0.822 ng/mL, respectively, after treatment (
p
= 0.0063). The mean of ADC changes in PSA response group before and after CIRT was significantly higher than that in non-PSA response group (∆ADC value: 0.217 vs 0.097 × 10
−3
mm
2
/s,
p
= 0.0229), and the rate of patients with PSA response was higher in the high ∆ADC group (∆ADC ≥ 0.10) than in the low ∆ADC group (∆ADC < 0.10) (72.7 and 33.3 %, respectively), but marginally significant (
p
= 0.056). Additionally, the baseline tumor ADC values revealed a negative correlation with changes in PSA levels after treatment (correlation coefficient,
ρ
= −0.524;
p
= 0.0025).
Conclusion
Our preliminary results suggest that ADC vales measurement may be a useful imaging biomarker for prediction and early assessment of therapeutic response of prostate cancer to CIRT.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>27008005</pmid><doi>10.1007/s00432-016-2142-3</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0171-5216 |
| ispartof | Journal of cancer research and clinical oncology, 2016-06, Vol.142 (6), p.1361-1367 |
| issn | 0171-5216 1432-1335 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1789038774 |
| source | MEDLINE; Springer Online Journals Complete |
| subjects | Aged Aged, 80 and over Cancer Research Carbon China Hematology Humans Internal Medicine Ions Magnetic Resonance Imaging Male Medicine Medicine & Public Health Middle Aged Oncology Original Article – Clinical Oncology Prostate cancer Prostatic Neoplasms - radiotherapy Protons Radiation therapy Radiotherapy - methods Retrospective Studies |
| title | The predictive role of ADC values in prostate cancer patients treated with carbon-ion radiotherapy: initial clinical experience at Shanghai Proton and Heavy Ion Center (SPHIC) |
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