Integrin α4 Induces Lymphangiogenesis and Metastasis via Upregulation of VEGF‐C in Human Colon Cancer

ABSTRACT Vascular endothelial growth factor‐C (VEGF‐C) is a key regulator in lymphangiogenesis, and is overexpressed in various malignancies. Integrin α4β1, a new member of the VEGF‐C/VEGF receptor pathway, was found to be overexpressed in melanoma tumors. However, little is known regarding the pote...

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Veröffentlicht in:	Anatomical record (Hoboken, N.J. : 2007) N.J. : 2007), 2016-06, Vol.299 (6), p.741-747
Hauptverfasser:	Lv, Xiao‐Hong, Liu, Bao‐Quan, Li, Xue‐Mei, Wang, Xiang‐Chen, Li, Xin‐Lei, Ahmed, Naila, Zhang, Ya‐Fang
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over colon cancer Colonic Neoplasms - metabolism Colonic Neoplasms - mortality Colonic Neoplasms - pathology Female Humans Integrin alpha4 - metabolism integrin α4 Lymphangiogenesis - physiology lymphatic metastasis Lymphatic Metastasis - pathology Lymphatic Vessels - metabolism Lymphatic Vessels - pathology Male Microvessels - metabolism Microvessels - pathology Middle Aged Prognosis Survival Rate Up-Regulation Vascular Endothelial Growth Factor C - metabolism Vascular Endothelial Growth Factor Receptor-3 - metabolism vascular endothelial growth factor‐C VEGFR‐3 Young Adult
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