CYP1A2 protects against reactive oxygen production in mouse liver microsomes

H 2O 2 production was evaluated in liver microsomes prepared from Cyp1a1/1a2(+/+) wild-type and Cyp1a1(−/−) and Cyp1a2(−/−) knockout mice pretreated with 5 μg dioxin (TCDD)/kg body wt or vehicle alone. NADPH-dependent H 2O 2 production in TCDD-induced microsomes from wild-type mice was about one-thi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Free radical biology & medicine 2004-03, Vol.36 (5), p.605-617
Hauptverfasser:	Shertzer, Howard G., Clay, Corey D., Genter, Mary Beth, Schneider, Scott N., Nebert, Daniel W., Dalton, Timothy P.
Format:	Artikel
Sprache:	eng
Schlagworte:	2,3,7,8-Tetrahydrodibenzo- p-dioxin Animals CYP1A1 CYP1A2 CYP2E1 Cytochrome P-450 CYP1A1 - metabolism Cytochrome P-450 CYP1A2 - metabolism Cytochrome P-450 CYP1A2 Inhibitors Cytochrome P-450 CYP2E1 - metabolism Cytochrome P-450 CYP2E1 Inhibitors Dioxins - toxicity Ditiocarb - pharmacology Electron Transport Enzyme Induction - drug effects Enzyme Inhibitors - pharmacology Free radicals Hydrogen Peroxide - metabolism Mice Mice, Knockout Microsomes, Liver - drug effects Microsomes, Liver - enzymology Mouse liver NADP - metabolism Oxidative stress Oxidative Stress - physiology Reactive oxygen Reactive Oxygen Species - metabolism Theophylline - analogs & derivatives Theophylline - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!