Aβ-related memory decline in APOE ε4 noncarriers: Implications for Alzheimer disease

OBJECTIVE:As the absence of Aβ-related memory decline in APOE ε4 noncarriers may be due to the relative brevity of previous studies, we aimed to characterize Aβ-related cognitive decline over 72 months in APOE ε4 carriers and noncarriers who were cognitively normal (CN). METHODS:CN older adults (n =...

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Veröffentlicht in:	Neurology 2016-04, Vol.86 (17), p.1635-1642
Hauptverfasser:	Lim, Yen Ying, Laws, Simon M, Villemagne, Victor L, Pietrzak, Robert H, Porter, Tenielle, Ames, David, Fowler, Christopher, Rainey-Smith, Stephanie, Snyder, Peter J, Martins, Ralph N, Salvado, Olivier, Bourgeat, Pierrick, Rowe, Christopher C, Masters, Colin L, Maruff, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Alzheimer Disease - diagnostic imaging Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer Disease - psychology Amyloid beta-Peptides - metabolism Apolipoprotein E4 - genetics Brain - diagnostic imaging Brain - metabolism Cognitive Dysfunction - diagnostic imaging Cognitive Dysfunction - genetics Cognitive Dysfunction - metabolism Cognitive Dysfunction - psychology Disease Progression Female Heterozygote Humans Male Memory Disorders - diagnostic imaging Memory Disorders - genetics Memory Disorders - metabolism Memory, Episodic Neuropsychological Tests Positron-Emission Tomography Prodromal Symptoms
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