Identification and characterisation of citrullinated antigen-specific B cells in peripheral blood of patients with rheumatoid arthritis

ObjectivesImmunity to citrullinated antigens is a hallmark of rheumatoid arthritis (RA). We set out to elucidate its biology by identifying and characterising citrullinated antigen-specific B cells in peripheral blood of patients with RA.MethodsDifferentially labelled streptavidin and extravidin tet...

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Veröffentlicht in:	Annals of the rheumatic diseases 2016-06, Vol.75 (6), p.1170-1176
Hauptverfasser:	Kerkman, Priscilla F, Fabre, Emeline, van der Voort, Ellen I H, Zaldumbide, Arnaud, Rombouts, Yoann, Rispens, Theo, Wolbink, Gertjan, Hoeben, Rob C, Spits, Hergen, Baeten, Dominique L P, Huizinga, Tom W J, Toes, René E M, Scherer, Hans U
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antigens Arthritis, Rheumatoid - immunology Autoantibodies - biosynthesis Autoantibodies - blood Autoantigens - immunology B-Lymphocyte Subsets - immunology Cells Cells, Cultured Cloning Cytomegalovirus Flow cytometry Humans Immunoglobulin G - biosynthesis Immunoglobulin G - blood Immunophenotyping Penicillin Peptides Peptides, Cyclic - immunology Proteins Rheumatoid arthritis
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