Blocking interferon γ reduces expression of chemokines CXCL9, CXCL10 and CXCL11 and decreases macrophage infiltration in ex vivo cultured arteries from patients with giant cell arteritis

BackgroundInterferon γ (IFNγ) is considered a seminal cytokine in the pathogenesis of giant cell arteritis (GCA), but its functional role has not been investigated. We explored changes in infiltrating cells and biomarkers elicited by blocking IFNγ with a neutralising monoclonal antibody, A6, in temp...

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Veröffentlicht in:	Annals of the rheumatic diseases 2016-06, Vol.75 (6), p.1177-1186
Hauptverfasser:	Corbera-Bellalta, Marc, Planas-Rigol, Ester, Lozano, Ester, Terrades-García, Nekane, Alba, Marco A, Prieto-González, Sergio, García-Martínez, Ana, Albero, Robert, Enjuanes, Anna, Espígol-Frigolé, Georgina, Hernández-Rodríguez, José, Roux-Lombard, Pascale, Ferlin, Walter G, Dayer, Jean-Michel, Kosco-Vilbois, Marie H, Cid, Maria C
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Cells, Cultured Chemokine CXCL10 - genetics Chemokine CXCL10 - metabolism Chemokine CXCL11 - genetics Chemokine CXCL11 - metabolism Chemokine CXCL9 - genetics Chemokine CXCL9 - metabolism Chemokines, CXC - genetics Chemokines, CXC - metabolism Chemotaxis - immunology Down-Regulation - immunology Female Gene Expression Regulation - drug effects Giant Cell Arteritis - immunology Humans Interferon-gamma - antagonists & inhibitors Interferon-gamma - biosynthesis Interferon-gamma - pharmacology Macrophages - immunology Male Muscle, Smooth, Vascular - immunology STAT1 Transcription Factor - genetics STAT1 Transcription Factor - metabolism Temporal Arteries - immunology Tissue Culture Techniques
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