Cytogenetic detection of a trans‐species bystander effect: induction of sister chromatid exchanges in murine 3T3 cells by ganciclovir metabolized in HSV thymidine kinase gene‐transfected Chinese hamster ovary cells

Due to the very limited transduction capacity of hitherto available vectors, the success of gene therapy of tumours by means of suicide genes has so far essentially depended on the transfer of toxic drug metabolites from transduced (metabolizing) cells to adjacent non‐transduced cells via gap juncti...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Mutagenesis 2004-01, Vol.19 (1), p.27-33
Hauptverfasser:	Thust, R., Tomicic, M.T., Gräbner, R., Friedrichs, C., Wutzler, P., Kaina, B.
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals Biological and medical sciences Bystander Effect bystander effects CHO Cells Connexin 43 - drug effects Connexin 43 - metabolism Cricetinae Cytogenetic Analysis - methods Fundamental and applied biological sciences. Psychology Ganciclovir - metabolism Ganciclovir - pharmacology Gap Junctions - drug effects Genetic Therapy - methods Glycyrrhetinic Acid - analogs & derivatives Glycyrrhetinic Acid - pharmacology Herpesvirus 1, Human - genetics Mice Molecular and cellular biology Molecular genetics Mutagenesis. Repair Sister Chromatid Exchange - drug effects Thymidine Kinase - genetics Transfection
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!