Estrogenic Activity and Metabolism of N-Butyl Benzyl Phthalate in Vitro: Identification of the Active Molecule(s)

Some phthalates are suspected to disrupt the endocrine system, especially by mimicking estrogens. N-butyl benzyl phthalate (BBP) has estrogenic effects in vitro but not in vivo. The aim of this study was to identify the active molecule(s) (parent compound and/or metabolite(s)) involved in the estrog...

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Veröffentlicht in:	Toxicology and applied pharmacology 2001-04, Vol.172 (2), p.108-118
Hauptverfasser:	Picard, Karine, Lhuguenot, Jean-Claude, Lavier-Canivenc, Marie-Chantal, Chagnon, Marie-Christine
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding, Competitive Biological and medical sciences Breast Neoplasms - metabolism Breast Neoplasms - pathology butyl benzyl phthalate Cell Division - drug effects Chemical and industrial products toxicology. Toxic occupational diseases Cytosol - metabolism E-Screen Estradiol - metabolism Estradiol - toxicity estrogen receptor binding Estrogen Receptor Modulators - pharmacology estrogen-like Estrogens, Non-Steroidal - metabolism Estrogens, Non-Steroidal - toxicity Gas Chromatography-Mass Spectrometry Hippurates - pharmacology Humans MCF-7 cell line Medical sciences metabolism in MCF-7 cells Molecular Mimicry n-butyl benzyl phthalate Phthalic Acids - metabolism Phthalic Acids - toxicity progesterone receptors Receptors, Estrogen - metabolism Receptors, Progesterone - biosynthesis Tamoxifen - pharmacology Toxicology Tumor Cells, Cultured Various organic compounds xenoestrogens
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