Study on anti-inflammatory efficacy and correlative ingredients with pharmacodynamics detected in acute inflammation rat model serum from Caulis Lonicerae japonicae
Caulis Lonicerae japonicae (CLJ) is often used for the treatment of inflammation such as acute fever, headache, respiratory infection and epidemic diseases. Nevertheless, domestic and foreign researches simply fail to focus on reports of CLJ, especially its anti-inflammatory effects and correlative...
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| Veröffentlicht in: | Phytomedicine (Stuttgart) 2016-06, Vol.23 (6), p.597-610 |
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| creator | Tang, Yuanlin Yin, Lian Zhang, Yida Huang, Xi Zhao, Fangli Cui, Xiaobing Shi, Le Xu, Li |
| description | Caulis Lonicerae japonicae (CLJ) is often used for the treatment of inflammation such as acute fever, headache, respiratory infection and epidemic diseases. Nevertheless, domestic and foreign researches simply fail to focus on reports of CLJ, especially its anti-inflammatory effects and correlative components.
In this study, we investigated anti-inflammatory effects and serum components of Caulis Lonicerae japonicae (CLJ) in models of acute inflammation and correlative analysis between anti-inflammatory effects and serum components of CLJ in rat serum to analyze the changes in the relative contents of components in serum with time and in the corresponding values to characterize active fractions of CLJ and identify the major active components of CLJ in rats.
Active fractions of CLJ were screened using xylene-induced ear oedema mice model. Anti-inflammatory effects were evaluated using carrageenan-induced paw oedema rat model, and then correlative components in rat serum were demonstrated with HPLC-QTOF/MS/MS method explored.
HPLC-QTOF/MS/MS was developed to analyze the components absorbed in rat serum after oral administration of CLJ.
Ethyl acetate extracts (ECLJ) and n-butanol extracts (BCLJ) of CLJ were preliminarily screened as active fractions of CLJ (EBCLJ) using xylene-induced ear oedema mice model, and effectively inhibited edema and values of interleukin-1 (IL-l), nuclear factor-kappaB (NF-kB), tumor necrosis factor-α (TNF-α) activities and prostaglandinE2 (PGE2) productions using carrageenan-induced paw oedema rat model. 33 peaks were found in total ion current chromatograms of EBCLJ, and 27 components were observed in EBCLJ-treated rat serum, only 11 of which were correlated with anti-inflammatory effects.
The present study contributes to the study on the pharmacodynamic basis of CLJ and provides potent evidence for developing CLJ as a safe and promising natural drug in inflammation treatment.
[Display omitted] |
| doi_str_mv | 10.1016/j.phymed.2016.01.016 |
| format | Article |
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In this study, we investigated anti-inflammatory effects and serum components of Caulis Lonicerae japonicae (CLJ) in models of acute inflammation and correlative analysis between anti-inflammatory effects and serum components of CLJ in rat serum to analyze the changes in the relative contents of components in serum with time and in the corresponding values to characterize active fractions of CLJ and identify the major active components of CLJ in rats.
Active fractions of CLJ were screened using xylene-induced ear oedema mice model. Anti-inflammatory effects were evaluated using carrageenan-induced paw oedema rat model, and then correlative components in rat serum were demonstrated with HPLC-QTOF/MS/MS method explored.
HPLC-QTOF/MS/MS was developed to analyze the components absorbed in rat serum after oral administration of CLJ.
Ethyl acetate extracts (ECLJ) and n-butanol extracts (BCLJ) of CLJ were preliminarily screened as active fractions of CLJ (EBCLJ) using xylene-induced ear oedema mice model, and effectively inhibited edema and values of interleukin-1 (IL-l), nuclear factor-kappaB (NF-kB), tumor necrosis factor-α (TNF-α) activities and prostaglandinE2 (PGE2) productions using carrageenan-induced paw oedema rat model. 33 peaks were found in total ion current chromatograms of EBCLJ, and 27 components were observed in EBCLJ-treated rat serum, only 11 of which were correlated with anti-inflammatory effects.
The present study contributes to the study on the pharmacodynamic basis of CLJ and provides potent evidence for developing CLJ as a safe and promising natural drug in inflammation treatment.
[Display omitted]</description><identifier>ISSN: 0944-7113</identifier><identifier>EISSN: 1618-095X</identifier><identifier>DOI: 10.1016/j.phymed.2016.01.016</identifier><identifier>PMID: 27161401</identifier><language>eng</language><publisher>Germany: Elsevier GmbH</publisher><subject>Active fractions ; Animals ; Anti-Inflammatory Agents - pharmacology ; Anti-inflammatory drugs ; Anti-inflammatory effect ; Care and treatment ; Caulis Lonicerae japonicae ; China ; Complications and side effects ; Correlation analysis between anti-inflammatory effects and serum components ; Disease Models, Animal ; Dosage and administration ; Drug therapy ; Inflammation ; Inflammation - drug therapy ; Lonicera - chemistry ; Male ; Medicine, Botanic ; Medicine, Herbal ; Mice ; Pharmacology ; Phytotherapy ; Plant Extracts - pharmacology ; Rats ; Rats, Sprague-Dawley ; Serum components</subject><ispartof>Phytomedicine (Stuttgart), 2016-06, Vol.23 (6), p.597-610</ispartof><rights>2016 Elsevier GmbH</rights><rights>Copyright © 2016 Elsevier GmbH. All rights reserved.</rights><rights>COPYRIGHT 2016 Urban & Fischer Verlag</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c467t-d19583da00091af1937cbddf16c356166fc2c8542699a0d5dd39c2c156fa28cc3</citedby><cites>FETCH-LOGICAL-c467t-d19583da00091af1937cbddf16c356166fc2c8542699a0d5dd39c2c156fa28cc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.phymed.2016.01.016$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27161401$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tang, Yuanlin</creatorcontrib><creatorcontrib>Yin, Lian</creatorcontrib><creatorcontrib>Zhang, Yida</creatorcontrib><creatorcontrib>Huang, Xi</creatorcontrib><creatorcontrib>Zhao, Fangli</creatorcontrib><creatorcontrib>Cui, Xiaobing</creatorcontrib><creatorcontrib>Shi, Le</creatorcontrib><creatorcontrib>Xu, Li</creatorcontrib><title>Study on anti-inflammatory efficacy and correlative ingredients with pharmacodynamics detected in acute inflammation rat model serum from Caulis Lonicerae japonicae</title><title>Phytomedicine (Stuttgart)</title><addtitle>Phytomedicine</addtitle><description>Caulis Lonicerae japonicae (CLJ) is often used for the treatment of inflammation such as acute fever, headache, respiratory infection and epidemic diseases. Nevertheless, domestic and foreign researches simply fail to focus on reports of CLJ, especially its anti-inflammatory effects and correlative components.
In this study, we investigated anti-inflammatory effects and serum components of Caulis Lonicerae japonicae (CLJ) in models of acute inflammation and correlative analysis between anti-inflammatory effects and serum components of CLJ in rat serum to analyze the changes in the relative contents of components in serum with time and in the corresponding values to characterize active fractions of CLJ and identify the major active components of CLJ in rats.
Active fractions of CLJ were screened using xylene-induced ear oedema mice model. Anti-inflammatory effects were evaluated using carrageenan-induced paw oedema rat model, and then correlative components in rat serum were demonstrated with HPLC-QTOF/MS/MS method explored.
HPLC-QTOF/MS/MS was developed to analyze the components absorbed in rat serum after oral administration of CLJ.
Ethyl acetate extracts (ECLJ) and n-butanol extracts (BCLJ) of CLJ were preliminarily screened as active fractions of CLJ (EBCLJ) using xylene-induced ear oedema mice model, and effectively inhibited edema and values of interleukin-1 (IL-l), nuclear factor-kappaB (NF-kB), tumor necrosis factor-α (TNF-α) activities and prostaglandinE2 (PGE2) productions using carrageenan-induced paw oedema rat model. 33 peaks were found in total ion current chromatograms of EBCLJ, and 27 components were observed in EBCLJ-treated rat serum, only 11 of which were correlated with anti-inflammatory effects.
The present study contributes to the study on the pharmacodynamic basis of CLJ and provides potent evidence for developing CLJ as a safe and promising natural drug in inflammation treatment.
[Display omitted]</description><subject>Active fractions</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Anti-inflammatory drugs</subject><subject>Anti-inflammatory effect</subject><subject>Care and treatment</subject><subject>Caulis Lonicerae japonicae</subject><subject>China</subject><subject>Complications and side effects</subject><subject>Correlation analysis between anti-inflammatory effects and serum components</subject><subject>Disease Models, Animal</subject><subject>Dosage and administration</subject><subject>Drug therapy</subject><subject>Inflammation</subject><subject>Inflammation - drug therapy</subject><subject>Lonicera - chemistry</subject><subject>Male</subject><subject>Medicine, Botanic</subject><subject>Medicine, Herbal</subject><subject>Mice</subject><subject>Pharmacology</subject><subject>Phytotherapy</subject><subject>Plant Extracts - pharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Serum components</subject><issn>0944-7113</issn><issn>1618-095X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kk2LFDEQhhtR3HH1H4gEvHjpMemPdPdFWIbVFQY8qOAt1CaVmQzdnTFJ79L_xx9qNTN7EAZJIF_PW0Wl3ix7K_hacCE_HtbH_TygWRd0WnNBUz7LVkKKNudd_et5tuJdVeWNEOVV9irGA-ei6hr-MrsqGsIqLlbZn-9pMjPzI4MxudyNtodhgOTDzNBap0HP9GSY9iFgD8k9IHPjLqBxOKbIHl3as-MewgDam3mEwenIDCbUCQ2hDPSUFs05sqNcARIbvMGeRQzTwGzwA9vA1LvItn50GgMgO8Bx2QO-zl5Y6CO-Oa_X2c_Ptz82d_n225evm5ttrivZpNyIrm5LA5zzToAVXdnoe2OskLqspZDS6kK3dVXIrgNuamPKjm5ELS0UrdbldfbhFPcY_O8JY1KDixr7Hkb0U1SiaduiaIqmIfT9Cd1Bj4qK8ymAXnB1U9Wy442sCqLyC9QOR6qv9yNaR9f_8OsLPA2D9K0XBdVJoIOPMaBVx-AGCLMSXC02UQd1solabKK4oClJ9u5c6HS_vD2JnnxBwKcTgPTdDw6Dipr6ranrgRqrjHf_z_AXbVfSzA</recordid><startdate>20160601</startdate><enddate>20160601</enddate><creator>Tang, Yuanlin</creator><creator>Yin, Lian</creator><creator>Zhang, Yida</creator><creator>Huang, Xi</creator><creator>Zhao, Fangli</creator><creator>Cui, Xiaobing</creator><creator>Shi, Le</creator><creator>Xu, Li</creator><general>Elsevier GmbH</general><general>Urban & Fischer Verlag</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160601</creationdate><title>Study on anti-inflammatory efficacy and correlative ingredients with pharmacodynamics detected in acute inflammation rat model serum from Caulis Lonicerae japonicae</title><author>Tang, Yuanlin ; Yin, Lian ; Zhang, Yida ; Huang, Xi ; Zhao, Fangli ; Cui, Xiaobing ; Shi, Le ; Xu, Li</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c467t-d19583da00091af1937cbddf16c356166fc2c8542699a0d5dd39c2c156fa28cc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Active fractions</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Anti-inflammatory drugs</topic><topic>Anti-inflammatory effect</topic><topic>Care and treatment</topic><topic>Caulis Lonicerae japonicae</topic><topic>China</topic><topic>Complications and side effects</topic><topic>Correlation analysis between anti-inflammatory effects and serum components</topic><topic>Disease Models, Animal</topic><topic>Dosage and administration</topic><topic>Drug therapy</topic><topic>Inflammation</topic><topic>Inflammation - drug therapy</topic><topic>Lonicera - chemistry</topic><topic>Male</topic><topic>Medicine, Botanic</topic><topic>Medicine, Herbal</topic><topic>Mice</topic><topic>Pharmacology</topic><topic>Phytotherapy</topic><topic>Plant Extracts - pharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Serum components</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tang, Yuanlin</creatorcontrib><creatorcontrib>Yin, Lian</creatorcontrib><creatorcontrib>Zhang, Yida</creatorcontrib><creatorcontrib>Huang, Xi</creatorcontrib><creatorcontrib>Zhao, Fangli</creatorcontrib><creatorcontrib>Cui, Xiaobing</creatorcontrib><creatorcontrib>Shi, Le</creatorcontrib><creatorcontrib>Xu, Li</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Phytomedicine (Stuttgart)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tang, Yuanlin</au><au>Yin, Lian</au><au>Zhang, Yida</au><au>Huang, Xi</au><au>Zhao, Fangli</au><au>Cui, Xiaobing</au><au>Shi, Le</au><au>Xu, Li</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Study on anti-inflammatory efficacy and correlative ingredients with pharmacodynamics detected in acute inflammation rat model serum from Caulis Lonicerae japonicae</atitle><jtitle>Phytomedicine (Stuttgart)</jtitle><addtitle>Phytomedicine</addtitle><date>2016-06-01</date><risdate>2016</risdate><volume>23</volume><issue>6</issue><spage>597</spage><epage>610</epage><pages>597-610</pages><issn>0944-7113</issn><eissn>1618-095X</eissn><abstract>Caulis Lonicerae japonicae (CLJ) is often used for the treatment of inflammation such as acute fever, headache, respiratory infection and epidemic diseases. Nevertheless, domestic and foreign researches simply fail to focus on reports of CLJ, especially its anti-inflammatory effects and correlative components.
In this study, we investigated anti-inflammatory effects and serum components of Caulis Lonicerae japonicae (CLJ) in models of acute inflammation and correlative analysis between anti-inflammatory effects and serum components of CLJ in rat serum to analyze the changes in the relative contents of components in serum with time and in the corresponding values to characterize active fractions of CLJ and identify the major active components of CLJ in rats.
Active fractions of CLJ were screened using xylene-induced ear oedema mice model. Anti-inflammatory effects were evaluated using carrageenan-induced paw oedema rat model, and then correlative components in rat serum were demonstrated with HPLC-QTOF/MS/MS method explored.
HPLC-QTOF/MS/MS was developed to analyze the components absorbed in rat serum after oral administration of CLJ.
Ethyl acetate extracts (ECLJ) and n-butanol extracts (BCLJ) of CLJ were preliminarily screened as active fractions of CLJ (EBCLJ) using xylene-induced ear oedema mice model, and effectively inhibited edema and values of interleukin-1 (IL-l), nuclear factor-kappaB (NF-kB), tumor necrosis factor-α (TNF-α) activities and prostaglandinE2 (PGE2) productions using carrageenan-induced paw oedema rat model. 33 peaks were found in total ion current chromatograms of EBCLJ, and 27 components were observed in EBCLJ-treated rat serum, only 11 of which were correlated with anti-inflammatory effects.
The present study contributes to the study on the pharmacodynamic basis of CLJ and provides potent evidence for developing CLJ as a safe and promising natural drug in inflammation treatment.
[Display omitted]</abstract><cop>Germany</cop><pub>Elsevier GmbH</pub><pmid>27161401</pmid><doi>10.1016/j.phymed.2016.01.016</doi><tpages>14</tpages></addata></record> |
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| subjects | Active fractions Animals Anti-Inflammatory Agents - pharmacology Anti-inflammatory drugs Anti-inflammatory effect Care and treatment Caulis Lonicerae japonicae China Complications and side effects Correlation analysis between anti-inflammatory effects and serum components Disease Models, Animal Dosage and administration Drug therapy Inflammation Inflammation - drug therapy Lonicera - chemistry Male Medicine, Botanic Medicine, Herbal Mice Pharmacology Phytotherapy Plant Extracts - pharmacology Rats Rats, Sprague-Dawley Serum components |
| title | Study on anti-inflammatory efficacy and correlative ingredients with pharmacodynamics detected in acute inflammation rat model serum from Caulis Lonicerae japonicae |
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