Effect of high mannose glycan pairing on IgG antibody clearance

IgG antibodies contain N-linked glycans on the Fc portion of each heavy chain. The glycan on one heavy chain can either match the glycan on the other heavy chain (symmetrical pairing) or be different (asymmetrical pairing). These Fc glycans influence effector functions and can alter clearance rates....

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Veröffentlicht in:	Biologicals 2016-05, Vol.44 (3), p.163-169
Hauptverfasser:	Liu, Yaoqing Diana, Flynn, Gregory C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - blood Antibodies, Monoclonal - metabolism Antibodies, Monoclonal - pharmacokinetics Antibody structure Humans Immunoglobulin G - metabolism Mannose - metabolism Mannose receptor Metabolic Clearance Rate Pharmacokinetics Polysaccharides - metabolism Therapeutic antibodies Time Factors
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