Shikonin Derivative DMAKO-05 Inhibits Akt Signal Activation and Melanoma Proliferation

DMAKO‐05((S)‐1‐((5E,8E)‐5,8‐bis(hydroxyimino)‐1,4‐dimethoxy‐5,8‐dihydronaphthalen‐2‐yl)‐4‐methylpent‐3‐enyl 3‐methylbutanoate) is a novel oxime derivative of shikonin, the major component extracted from Chinese herb Lithospermun erythrorhizon. Here, we report that DMAKO‐05 had an antitumor activity...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Chemical biology & drug design 2016-06, Vol.87 (6), p.895-904
Hauptverfasser:	Yang, Yao-yao, He, Hui-qiong, Cui, Jia-hua, Nie, Yun-juan, Wu, Ya-xian, Wang, Rui, Wang, Gang, Zheng, Jun-Nian, Ye, Richard D., Wu, Qiong, Li, Shao-shun, Qian, Feng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents, Phytogenic - chemical synthesis Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - pharmacology apoptosis cell cycle arrest Cell Line, Tumor Cell Proliferation - drug effects cytotoxicity DMAKO-05 Drug Screening Assays, Antitumor Melanoma - drug therapy Melanoma - metabolism melanoma cell B16F0 Naphthoquinones - chemical synthesis Naphthoquinones - chemistry Naphthoquinones - pharmacology Proto-Oncogene Proteins c-akt - metabolism Rats shikonin Signal Transduction - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!