Involving AP-2 transcription factor in connexin 26 up-regulation during pregnancy and lactation

Gap junction connexin 26 (Cx26) is up-regulated in mammary epithelial cells during pregnancy and lactation. To understand the transcriptional regulation of Cx26, we identified a protected DNase I footprint region (−140 to −113) in the rat Cx26 promoter. This rCx26 Promoter Footprinting Region, or CP...

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Veröffentlicht in:	Molecular reproduction and development 2001-05, Vol.59 (1), p.17-24
Hauptverfasser:	Tu, Zheng Jin, Pan, Weihong, Gong, Zhuo, Kiang, David T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals AP-2 protein AP-2 transcription factor Biological and medical sciences Cell Line Cell Nucleus - chemistry Cell Nucleus - metabolism Connexin 26 Connexins - genetics Connexins - metabolism CX26 gene DNA Footprinting DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Epithelial Cells - metabolism Female Fundamental and applied biological sciences. Psychology Gene Expression Regulation - genetics Genes, Reporter - genetics Humans Lactation - physiology mammary epithelial cells Mammary Glands, Animal - metabolism Molecular and cellular biology Molecular genetics Mutagenesis, Site-Directed Pregnancy pregnancy and lactation Promoter Regions, Genetic - genetics Rats Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Transcription Factors - genetics Transcription Factors - metabolism Transcription. Transcription factor. Splicing. Rna processing
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