Marked Strain-Specific Differences in the SU5416 Rat Model of Severe Pulmonary Arterial Hypertension

We assessed the pulmonary hemodynamic response to vascular endothelial growth factor receptor, type 2, inhibition using SU5416 (SU) with and without chronic hypoxia (CH) in different background strains and colonies of rats. A single subcutaneous injection of SU (20 mg/kg) or vehicle was administered...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 2016-04, Vol.54 (4), p.461-468
Hauptverfasser:	Jiang, Baohua, Deng, Yupu, Suen, Colin, Taha, Mohamad, Chaudhary, Ketul R, Courtman, David W, Stewart, Duncan J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Disease Models, Animal Genotype & phenotype Hypertension Hypertension, Pulmonary - drug therapy Hypertension, Pulmonary - pathology Hypoxia Indoles - therapeutic use Laboratory animals Medical prognosis Mortality Pyrroles - therapeutic use Rats Rats, Inbred F344 Rats, Inbred Lew Rats, Sprague-Dawley Rodents Species Specificity Studies Vascular endothelial growth factor
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