Oral application of lactic acid bacteria following treatment with antibiotics inhibits allergic airway inflammation
Aims To investigate whether lactic acid bacteria (LAB) can exhibit anti‐allergy properties in antibiotics‐treated mice model. Methods and Results Antibiotic treatment affected the composition of the intestinal microbiota and its metabolites, and thus has a mild effect on Th1/Th2 balance. Oral admini...
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| Veröffentlicht in: | Journal of applied microbiology 2015-09, Vol.119 (3), p.809-817 |
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| creator | Zhang, Q. Ai, C. Wang, G. Liu, X. Tian, F. Zhao, J. Zhang, H. Chen, Y.Q. Chen, W. |
| description | Aims
To investigate whether lactic acid bacteria (LAB) can exhibit anti‐allergy properties in antibiotics‐treated mice model.
Methods and Results
Antibiotic treatment affected the composition of the intestinal microbiota and its metabolites, and thus has a mild effect on Th1/Th2 balance. Oral administration of Streptococcus thermophilus CCFM218 (ST218) could not fully repair antibiotic‐induced damage to the intestinal microbiota and its metabolites, and restore them to their original condition. But ST218 treatment revealed a strong suppressive effect on airway inflammation characterized by reduced inflammatory cell infiltration and levels of Th2 cytokines in lung tissues, which was associated with an enhanced mucosal tolerance.
Conclusions
These results showed that ST218 could alleviate allergic responses in mice treated with antibiotics, primarily through the modulation of mucosal and systemic responses rather than the restoration of the intestinal microbiota.
Significance and Impact of the Study
The rise in incidence in allergies may correlate with the widespread and liberal use of antibiotics. This study affirmed that one species of LAB ST218 significantly reduces allergic airway inflammation in antibiotic‐treated mice model. |
| doi_str_mv | 10.1111/jam.12885 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1787984407</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1787984407</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4915-8fe9dd5162eb5af2b18b6424c627db8d1225db4000fd5a6e2e27a260190802693</originalsourceid><addsrcrecordid>eNqNkU1r3DAQhkVpaD7aQ_9AEfTSHJxoxpIsH0No0oaUXNqzGdtyokW2tpKWZf99ld20h0KhuswL8-gR4mXsPYgLKOdyRfMFoDHqFTuBWqsKdYOv91lWSjR4zE5TWgkBtVD6DTtGDdDWqj1h6SGS57ReezdQdmHhYeKehuwGToMbeV-yjY74FLwPW7c88hwt5dkumW9dfuK0ZNe7UG4k7panknPi5L2Nj88SF7e0K4vJ0zzvn3jLjibyyb57mWfsx83n79dfqvuH26_XV_fVIFtQlZlsO44KNNpe0YQ9mF5LlIPGZuzNCIhq7KUQYhoVaYsWG0ItoBVGoG7rM_bp4F3H8HNjU-5mlwbrPS02bFIHjWlaI6Vo_gMVGoWRDRb041_oKmziUj5SKBCga5B1oc4P1BBDStFO3Tq6meKuA9E9l9aV0rp9aYX98GLc9LMd_5C_WyrA5QHYOm93_zZ1d1ffDspfmnug6Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1710163143</pqid></control><display><type>article</type><title>Oral application of lactic acid bacteria following treatment with antibiotics inhibits allergic airway inflammation</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><source>Oxford University Press Journals All Titles (1996-Current)</source><creator>Zhang, Q. ; Ai, C. ; Wang, G. ; Liu, X. ; Tian, F. ; Zhao, J. ; Zhang, H. ; Chen, Y.Q. ; Chen, W.</creator><creatorcontrib>Zhang, Q. ; Ai, C. ; Wang, G. ; Liu, X. ; Tian, F. ; Zhao, J. ; Zhang, H. ; Chen, Y.Q. ; Chen, W.</creatorcontrib><description>Aims
To investigate whether lactic acid bacteria (LAB) can exhibit anti‐allergy properties in antibiotics‐treated mice model.
Methods and Results
Antibiotic treatment affected the composition of the intestinal microbiota and its metabolites, and thus has a mild effect on Th1/Th2 balance. Oral administration of Streptococcus thermophilus CCFM218 (ST218) could not fully repair antibiotic‐induced damage to the intestinal microbiota and its metabolites, and restore them to their original condition. But ST218 treatment revealed a strong suppressive effect on airway inflammation characterized by reduced inflammatory cell infiltration and levels of Th2 cytokines in lung tissues, which was associated with an enhanced mucosal tolerance.
Conclusions
These results showed that ST218 could alleviate allergic responses in mice treated with antibiotics, primarily through the modulation of mucosal and systemic responses rather than the restoration of the intestinal microbiota.
Significance and Impact of the Study
The rise in incidence in allergies may correlate with the widespread and liberal use of antibiotics. This study affirmed that one species of LAB ST218 significantly reduces allergic airway inflammation in antibiotic‐treated mice model.</description><identifier>ISSN: 1364-5072</identifier><identifier>EISSN: 1365-2672</identifier><identifier>DOI: 10.1111/jam.12885</identifier><identifier>PMID: 26119359</identifier><identifier>CODEN: JAMIFK</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Allergies ; allergy ; Animals ; Anti-Bacterial Agents - administration & dosage ; Anti-Bacterial Agents - adverse effects ; Antibiotics ; Bacteria ; Cytokines - genetics ; Cytokines - immunology ; Disease Models, Animal ; Female ; Humans ; Hypersensitivity - drug therapy ; Hypersensitivity - genetics ; Hypersensitivity - immunology ; Hypersensitivity - microbiology ; Inflammation ; intestinal microbiota ; Lactic Acid - metabolism ; lactic acid bacteria ; Lung - immunology ; Metabolites ; Mice ; Mice, Inbred BALB C ; Probiotics - administration & dosage ; Respiratory Tract Infections - drug therapy ; Respiratory Tract Infections - immunology ; Rodents ; Streptococcus thermophilus ; Streptococcus thermophilus - physiology ; Th2 Cells - immunology</subject><ispartof>Journal of applied microbiology, 2015-09, Vol.119 (3), p.809-817</ispartof><rights>2015 The Society for Applied Microbiology</rights><rights>2015 The Society for Applied Microbiology.</rights><rights>Copyright © 2015 The Society for Applied Microbiology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4915-8fe9dd5162eb5af2b18b6424c627db8d1225db4000fd5a6e2e27a260190802693</citedby><cites>FETCH-LOGICAL-c4915-8fe9dd5162eb5af2b18b6424c627db8d1225db4000fd5a6e2e27a260190802693</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjam.12885$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjam.12885$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26119359$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Q.</creatorcontrib><creatorcontrib>Ai, C.</creatorcontrib><creatorcontrib>Wang, G.</creatorcontrib><creatorcontrib>Liu, X.</creatorcontrib><creatorcontrib>Tian, F.</creatorcontrib><creatorcontrib>Zhao, J.</creatorcontrib><creatorcontrib>Zhang, H.</creatorcontrib><creatorcontrib>Chen, Y.Q.</creatorcontrib><creatorcontrib>Chen, W.</creatorcontrib><title>Oral application of lactic acid bacteria following treatment with antibiotics inhibits allergic airway inflammation</title><title>Journal of applied microbiology</title><addtitle>J Appl Microbiol</addtitle><description>Aims
To investigate whether lactic acid bacteria (LAB) can exhibit anti‐allergy properties in antibiotics‐treated mice model.
Methods and Results
Antibiotic treatment affected the composition of the intestinal microbiota and its metabolites, and thus has a mild effect on Th1/Th2 balance. Oral administration of Streptococcus thermophilus CCFM218 (ST218) could not fully repair antibiotic‐induced damage to the intestinal microbiota and its metabolites, and restore them to their original condition. But ST218 treatment revealed a strong suppressive effect on airway inflammation characterized by reduced inflammatory cell infiltration and levels of Th2 cytokines in lung tissues, which was associated with an enhanced mucosal tolerance.
Conclusions
These results showed that ST218 could alleviate allergic responses in mice treated with antibiotics, primarily through the modulation of mucosal and systemic responses rather than the restoration of the intestinal microbiota.
Significance and Impact of the Study
The rise in incidence in allergies may correlate with the widespread and liberal use of antibiotics. This study affirmed that one species of LAB ST218 significantly reduces allergic airway inflammation in antibiotic‐treated mice model.</description><subject>Allergies</subject><subject>allergy</subject><subject>Animals</subject><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>Anti-Bacterial Agents - adverse effects</subject><subject>Antibiotics</subject><subject>Bacteria</subject><subject>Cytokines - genetics</subject><subject>Cytokines - immunology</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Humans</subject><subject>Hypersensitivity - drug therapy</subject><subject>Hypersensitivity - genetics</subject><subject>Hypersensitivity - immunology</subject><subject>Hypersensitivity - microbiology</subject><subject>Inflammation</subject><subject>intestinal microbiota</subject><subject>Lactic Acid - metabolism</subject><subject>lactic acid bacteria</subject><subject>Lung - immunology</subject><subject>Metabolites</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Probiotics - administration & dosage</subject><subject>Respiratory Tract Infections - drug therapy</subject><subject>Respiratory Tract Infections - immunology</subject><subject>Rodents</subject><subject>Streptococcus thermophilus</subject><subject>Streptococcus thermophilus - physiology</subject><subject>Th2 Cells - immunology</subject><issn>1364-5072</issn><issn>1365-2672</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1r3DAQhkVpaD7aQ_9AEfTSHJxoxpIsH0No0oaUXNqzGdtyokW2tpKWZf99ld20h0KhuswL8-gR4mXsPYgLKOdyRfMFoDHqFTuBWqsKdYOv91lWSjR4zE5TWgkBtVD6DTtGDdDWqj1h6SGS57ReezdQdmHhYeKehuwGToMbeV-yjY74FLwPW7c88hwt5dkumW9dfuK0ZNe7UG4k7panknPi5L2Nj88SF7e0K4vJ0zzvn3jLjibyyb57mWfsx83n79dfqvuH26_XV_fVIFtQlZlsO44KNNpe0YQ9mF5LlIPGZuzNCIhq7KUQYhoVaYsWG0ItoBVGoG7rM_bp4F3H8HNjU-5mlwbrPS02bFIHjWlaI6Vo_gMVGoWRDRb041_oKmziUj5SKBCga5B1oc4P1BBDStFO3Tq6meKuA9E9l9aV0rp9aYX98GLc9LMd_5C_WyrA5QHYOm93_zZ1d1ffDspfmnug6Q</recordid><startdate>201509</startdate><enddate>201509</enddate><creator>Zhang, Q.</creator><creator>Ai, C.</creator><creator>Wang, G.</creator><creator>Liu, X.</creator><creator>Tian, F.</creator><creator>Zhao, J.</creator><creator>Zhang, H.</creator><creator>Chen, Y.Q.</creator><creator>Chen, W.</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TM</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>7ST</scope><scope>SOI</scope></search><sort><creationdate>201509</creationdate><title>Oral application of lactic acid bacteria following treatment with antibiotics inhibits allergic airway inflammation</title><author>Zhang, Q. ; Ai, C. ; Wang, G. ; Liu, X. ; Tian, F. ; Zhao, J. ; Zhang, H. ; Chen, Y.Q. ; Chen, W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4915-8fe9dd5162eb5af2b18b6424c627db8d1225db4000fd5a6e2e27a260190802693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Allergies</topic><topic>allergy</topic><topic>Animals</topic><topic>Anti-Bacterial Agents - administration & dosage</topic><topic>Anti-Bacterial Agents - adverse effects</topic><topic>Antibiotics</topic><topic>Bacteria</topic><topic>Cytokines - genetics</topic><topic>Cytokines - immunology</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>Humans</topic><topic>Hypersensitivity - drug therapy</topic><topic>Hypersensitivity - genetics</topic><topic>Hypersensitivity - immunology</topic><topic>Hypersensitivity - microbiology</topic><topic>Inflammation</topic><topic>intestinal microbiota</topic><topic>Lactic Acid - metabolism</topic><topic>lactic acid bacteria</topic><topic>Lung - immunology</topic><topic>Metabolites</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Probiotics - administration & dosage</topic><topic>Respiratory Tract Infections - drug therapy</topic><topic>Respiratory Tract Infections - immunology</topic><topic>Rodents</topic><topic>Streptococcus thermophilus</topic><topic>Streptococcus thermophilus - physiology</topic><topic>Th2 Cells - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Q.</creatorcontrib><creatorcontrib>Ai, C.</creatorcontrib><creatorcontrib>Wang, G.</creatorcontrib><creatorcontrib>Liu, X.</creatorcontrib><creatorcontrib>Tian, F.</creatorcontrib><creatorcontrib>Zhao, J.</creatorcontrib><creatorcontrib>Zhang, H.</creatorcontrib><creatorcontrib>Chen, Y.Q.</creatorcontrib><creatorcontrib>Chen, W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Environment Abstracts</collection><collection>Environment Abstracts</collection><jtitle>Journal of applied microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Q.</au><au>Ai, C.</au><au>Wang, G.</au><au>Liu, X.</au><au>Tian, F.</au><au>Zhao, J.</au><au>Zhang, H.</au><au>Chen, Y.Q.</au><au>Chen, W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oral application of lactic acid bacteria following treatment with antibiotics inhibits allergic airway inflammation</atitle><jtitle>Journal of applied microbiology</jtitle><addtitle>J Appl Microbiol</addtitle><date>2015-09</date><risdate>2015</risdate><volume>119</volume><issue>3</issue><spage>809</spage><epage>817</epage><pages>809-817</pages><issn>1364-5072</issn><eissn>1365-2672</eissn><coden>JAMIFK</coden><abstract>Aims
To investigate whether lactic acid bacteria (LAB) can exhibit anti‐allergy properties in antibiotics‐treated mice model.
Methods and Results
Antibiotic treatment affected the composition of the intestinal microbiota and its metabolites, and thus has a mild effect on Th1/Th2 balance. Oral administration of Streptococcus thermophilus CCFM218 (ST218) could not fully repair antibiotic‐induced damage to the intestinal microbiota and its metabolites, and restore them to their original condition. But ST218 treatment revealed a strong suppressive effect on airway inflammation characterized by reduced inflammatory cell infiltration and levels of Th2 cytokines in lung tissues, which was associated with an enhanced mucosal tolerance.
Conclusions
These results showed that ST218 could alleviate allergic responses in mice treated with antibiotics, primarily through the modulation of mucosal and systemic responses rather than the restoration of the intestinal microbiota.
Significance and Impact of the Study
The rise in incidence in allergies may correlate with the widespread and liberal use of antibiotics. This study affirmed that one species of LAB ST218 significantly reduces allergic airway inflammation in antibiotic‐treated mice model.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>26119359</pmid><doi>10.1111/jam.12885</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Access via Wiley Online Library; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Allergies allergy Animals Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - adverse effects Antibiotics Bacteria Cytokines - genetics Cytokines - immunology Disease Models, Animal Female Humans Hypersensitivity - drug therapy Hypersensitivity - genetics Hypersensitivity - immunology Hypersensitivity - microbiology Inflammation intestinal microbiota Lactic Acid - metabolism lactic acid bacteria Lung - immunology Metabolites Mice Mice, Inbred BALB C Probiotics - administration & dosage Respiratory Tract Infections - drug therapy Respiratory Tract Infections - immunology Rodents Streptococcus thermophilus Streptococcus thermophilus - physiology Th2 Cells - immunology |
| title | Oral application of lactic acid bacteria following treatment with antibiotics inhibits allergic airway inflammation |
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