Adenosine A1 Receptor-Mediated Endocytosis of AMPA Receptors Contributes to Impairments in Long-Term Potentiation (LTP) in the Middle-Aged Rat Hippocampus

Aging causes multiple changes in the mammalian brain, including changes in synaptic signaling. Previous reports have shown increased extracellular adenosine in the aging brain, and we recently reported that activation of adenosine A1 receptors (A1Rs) induces AMPA receptor (AMPAR) internalization in...

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Veröffentlicht in:	Neurochemical research 2016-05, Vol.41 (5), p.1085-1097
Hauptverfasser:	Chen, Zhicheng, Stockwell, Jocelyn, Cayabyab, Francisco S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - physiology Animals Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology Clathrin - physiology Endocytosis Hippocampus - physiology Long-Term Potentiation Male Neurochemistry Neurology Neurosciences Original Paper Rats, Sprague-Dawley Receptor, Adenosine A1 - physiology Receptors, AMPA - physiology
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