Emerging concepts of T cell metabolism as a target of immunotherapy

In this Perspective, Chang and Pearce discuss recent progress in understanding how metabolic pathways control T cell function and how these pathways can be manipulated for therapeutic purposes. T cells have a pivotal protective role in defense against infection and cancer but also are instrumental i...

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Veröffentlicht in:	Nature immunology 2016-04, Vol.17 (4), p.364-368
Hauptverfasser:	Chang, Chih-Hao, Pearce, Erika L
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/1619/554 631/250/580 631/67/1059/2325 AMP-Activated Protein Kinases - metabolism Animals Autoimmune Diseases - immunology Autoimmune Diseases - metabolism Biomedicine Cell Differentiation - immunology Cell metabolism Glycolysis Health aspects Humans Immunology Immunotherapy Immunotherapy, Adoptive Infectious Diseases Innovations Longevity Metabolic Networks and Pathways Molecular targeted therapy Neoplasms - immunology Neoplasms - metabolism Neoplasms - therapy Nutrient uptake Nutrient utilization Oxidative Phosphorylation perspective Physiological aspects Signal Transduction T cells T-Lymphocytes - immunology T-Lymphocytes - metabolism TOR Serine-Threonine Kinases - metabolism Tumor Microenvironment - immunology
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