Immunogenicity and safety of two doses of catch-up immunization with Haemophilus influenzae type b conjugate vaccine in Indian children living with HIV
Highlights • The optimal schedule for HibCV in children with HIV is unclear in settings with limited access to ART. • The recommended schedule of 1 dose of HibCV may be inadequate in such settings. • 76% of HIV infected children 2–15 years mounted an immune response following 2-doses of HibCV. • Imm...
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| Veröffentlicht in: | Vaccine 2016-04, Vol.34 (19), p.2267-2274 |
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| creator | Arya, Bikas K Bhattacharya, Sangeeta Das Sutcliffe, Catherine G Saha, Malay K Bhattacharyya, Subhasish Niyogi, Swapan Kumar Moss, William J Panda, Samiran Das, Ranjan Saurav Mallick, Mausom Mandal, Sutapa |
| description | Highlights • The optimal schedule for HibCV in children with HIV is unclear in settings with limited access to ART. • The recommended schedule of 1 dose of HibCV may be inadequate in such settings. • 76% of HIV infected children 2–15 years mounted an immune response following 2-doses of HibCV. • Immune responses were adequate even among children with viral loads >100,000 copies/mL. • Anti-Hib-PRP IgG ≥ 3.3 μg/mL provided protection against Hib NP colonization in children with HIV. |
| doi_str_mv | 10.1016/j.vaccine.2016.03.012 |
| format | Article |
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blood</subject><subject>Antiretroviral agents</subject><subject>Antiretroviral drugs</subject><subject>Bacterial Capsules - immunology</subject><subject>Binding sites</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Colonization</subject><subject>Conjugate vaccines</subject><subject>Disease</subject><subject>Families & family life</subject><subject>Female</subject><subject>Haemophilus Infections - prevention & control</subject><subject>Haemophilus influenzae</subject><subject>Haemophilus influenzae type b</subject><subject>Haemophilus Vaccines - administration & dosage</subject><subject>Haemophilus Vaccines - immunology</subject><subject>Haemophilus Vaccines - therapeutic use</subject><subject>Health risks</subject><subject>HIV</subject><subject>HIV Infections</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immunization</subject><subject>Immunization Schedule</subject><subject>Immunization, Secondary</subject><subject>Immunogenicity</subject><subject>Immunoglobulin G - 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| subjects | Adolescent Age Allergy and Immunology Anti-Hib PRP IgG Antibodies, Bacterial - blood Antiretroviral agents Antiretroviral drugs Bacterial Capsules - immunology Binding sites Child Child, Preschool Colonization Conjugate vaccines Disease Families & family life Female Haemophilus Infections - prevention & control Haemophilus influenzae Haemophilus influenzae type b Haemophilus Vaccines - administration & dosage Haemophilus Vaccines - immunology Haemophilus Vaccines - therapeutic use Health risks HIV HIV Infections Human immunodeficiency virus Humans Immune response Immunization Immunization Schedule Immunization, Secondary Immunogenicity Immunoglobulin G - blood India Infant Laboratories Male Nasopharyngeal carriage Prophylaxis Prospective Studies Regression analysis Vaccines Vaccines, Conjugate - administration & dosage Vaccines, Conjugate - immunology Vaccines, Conjugate - therapeutic use Viral Load |
| title | Immunogenicity and safety of two doses of catch-up immunization with Haemophilus influenzae type b conjugate vaccine in Indian children living with HIV |
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